Recombinant Human IL6R Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | IL6R-3837H |
Product Overview : | IL6R MS Standard C13 and N15-labeled recombinant protein (NP_000556) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
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Description : | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 51.5 kDa |
AA Sequence : | MLAVGCALLAALLAAPGAALAPRRC PAQEVARGVLTSLPGDSVTLTCPGV EPEDNATVHWVLRKPAAGSHPSRWA GMGRRLLLRSVQLHDSGNYSCYRAG RPAGTVHLLVDVPPEEPQLSCFRKS PLSNVVCEWGPRSTPSLTTKAVLLV RKFQNSPAEDFQEPCQYSQESQKFS CQLAVPEGDSSFYIVSMCVASSVGS KFSKTQTFQGCGILQPDPPANITVT AVARNPRWLSVTWQDPHSWNSSFYR LRFELRYRAERSKTFTTWMVKDLQH HCVIHDAWSGLRHVVQLRAQEEFGQ GEWSEWSPEAMGTPWTESRSPPAEN EVSTPMQALTTNKDDDNILFRDSAN ATSLPVQASSSVPLPTFLVAGGSLA FGTLLCIAIVLRFKKTWKLRALKEG KTSMHPPYSLGQLVPERPRPTPVLV PLISPPVSPSSLGSDNTSSHNRPDA RDPRSPYDISNTDYFFPRTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | IL6R interleukin 6 receptor [ Homo sapiens (human) ] |
Official Symbol : | IL6R |
Synonyms : | IL6R; interleukin 6 receptor; interleukin-6 receptor subunit alpha; CD126; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha; gp80; IL6RA; IL-6RA; IL-6R-1; MGC104991; |
Gene ID : | 3570 |
mRNA Refseq : | NM_000565 |
Protein Refseq : | NP_000556 |
MIM : | 147880 |
UniProt ID : | P08887 |
Products Types
◆ Recombinant Protein | ||
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IL6R-139I | Active Recombinant Human IL6R Protein (350 aa), N-His-tagged | +Inquiry |
IL6R-584H | Active Recombinant Human IL6R Protein | +Inquiry |
IL6R-5174H | Recombinant Human IL6R Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
IL6R-2903HCL | Recombinant Human IL6R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe dose and route of administration need to be determined according to the specific treatment situation. Common routes of administration include subcutaneous injection and intravenous injection.
It can be used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.
The IL6R is primarily used to treat inflammatory diseases that have already occurred, rather than prevent them.
IL6R reduces inflammation by binding to interleukin-6 (IL-6), blocking the IL-6 signaling pathway.
Although IL6R can regulate the immune system, it is not a direct anti-tumor drug.
The efficacy of IL6R is usually evaluated based on improvement of clinical symptoms, changes in disease activity, and changes in biochemical markers.
Customer Reviews (3)
Write a reviewGood compatibility and stability with the surfactant.
Expression level and stability of clones were good.
Remarkable antibacterial activity and bactericidal effect on bacteria.
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