• Official Full Name

    interleukin 6 receptor

  • Background

    his gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
  • Synonyms

    IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; interleukin 6 receptor; IL6R;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Canine
    • Human
    • Macaca mulatta
    • Mouse
    • Rat
    • Rattus norvegicus (Rat)
    • Rhesus
    • Rhesus monkey
    • Sus scrofa (Pig)
    • Zebrafish
    • Source :
    • CHO
    • CHO cells
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293 cells
    • HEK293F
    • HEK293T
    • Human
    • Human Cell
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • SF9 insect cells
    • Wheat Germ
    • Yeast
    • Tag :
    • C
    • His
    • Fc
    • Avi
    • GST
    • hFc
    • hIgG1
    • hIgG4
    • His (Fc)
    • His(C
    • ter)
    • His|Avi
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Canine IL6R-1064C Recombinant Canine IL6R protein, His-tagged HEK293 His
    Human IL6R-2176H Recombinant Human IL6R Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL6R-201H Active Recombinant Human IL6R, HIgG1 Fc-tagged CHO Fc
    Human IL6R-322H Recombinant Human IL6R, Fc-tagged CHO Fc
    Human IL6R-29271TH Recombinant Human IL6R N/A
    Human IL6R-5175H Recombinant Human IL6R Protein Wheat Germ N/A
    Human IL6R-964H Recombinant Human Interleukin 6 Receptor E.coli N/A
    Human IL6R-786H Recombinant Human IL6R protein, His-tagged HEK293 His
    Human IL6R-2903HCL Recombinant Human IL6R cell lysate Human Cell N/A
    Human IL6R-1058H Recombinant Human IL-6 Protein E.coli N/A
    Human IL6R-545H Recombinant Human Interleukin 6 Receptor Human N/A
    Human IL6R-428H Active Recombinant Human IL6R, His-tagged Mammalian cells His
    Human IL6R-239H Recombinant Human IL6R, C13&N15-labeled HEK293 N/A
    Human IL6R-3837H Recombinant Human IL6R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL6R-787H Recombinant Human IL6R Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human IL6R-1242H Recombinant Human Interleukin 6 Receptor E.coli N/A
    Human IL6R-087H Recombinant Human IL6R protein, His-Avi-tagged HEK293 His-Avi
    Human IL6R-051H Active Recombinant Human IL6R protein, His/Avi-tagged, Biotinylated CHO cells His/Avi
    Human IL6R-5689HF Recombinant Full Length Human IL6R Protein In Vitro Cell Free System
    Human IL6R-5174H Recombinant Human IL6R Protein, GST-tagged Wheat Germ GST
    Human IL6R-3154H-B Recombinant Human IL6R Protein Pre-coupled Magnetic Beads HEK293
    Human IL6R-1054H Recombinant Human IL6R Protein, His-tagged HEK293F N-His
    Human IL6R-2768H Recombinant Human IL6R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL6R-5452H Recombinant Human IL6R protein, His-tagged Yeast His
    Human IL6R-788H Active Recombinant Human IL6R protein (Met1-Pro365), hFc-tagged HEK293 hFc
    Human IL6R-5692HF Recombinant Full Length Human IL6R Protein, GST-tagged In Vitro Cell Free System GST
    Human IL6R-139I Recombinant Human IL6R Protein (350 aa), N-His-tagged SF9 insect cells
    Human IL6R-213H Recombinant Human IL6R Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter)
    Human IL6R-3154H Recombinant Human IL6R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL6R-070H Recombinant Human IL6R Protein, C-His-tagged E.coli C-His
    Human IL6R-1593H Recombinant Human IL6R Protein (Met1-Pro365), C-His tagged Mammalian cells C-His
    Human IL6R-235I Recombinant Human IL6R Protein CHO
    Human IL6R-335H Recombinant Human IL6R Protein, His-tagged HEK293 His
    Human IL6R-517H Recombinant Human IL6R Protein, C13 and N15 Labeled
    Human IL6R-0185H Recombinant Human IL6R protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
    Human IL6R-200H Active Recombinant Human IL6R, MIgG2a Fc-tagged CHO Fc
    Human IL6R-584H Recombinant Human IL6R Protein HEK293 cells N/A
    Human IL6R-1241H Recombinant Human Interleukin 6 Receptor, His-tagged E.coli His
    Human IL6R-100H Recombinant Human Interleukin-6 Soluble Receptor,His-tagged E.coli His
    Human IL6R-0187H Recombinant Human IL6R protein, Fc-tagged HEK293 Fc
    Human IL6R-1418H Recombinant Human IL6R Protein (Met1-Pro365), N-His tagged E.coli N-His
    Macaca mulatta IL6R-9166H Recombinant Cynomolgus IL6R, His-tagged HEK293 His
    Mouse IL6R-0186M Recombinant Mouse IL6R protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Rat Il6r-1836R Recombinant Rat Il6r protein, His-tagged E.coli His
    Rat IL6R-056R Recombinant Rat IL6R protein, hFc-tagged HEK293 hFc
    Rat Il6r-935R Recombinant Rat Il6r, His-tagged Human Cell His
    Rat Il6r-9168H Recombinant Rat Il6r, His-tagged HEK293 His
    Rat Il6r-1145R Recombinant Rat Il6r Protein, His-tagged HEK293 His
    Rattus norvegicus (Rat) RFL7419RF Recombinant Full Length Rat Interleukin-6 Receptor Subunit Alpha(Il6R) Protein, His-Tagged E.coli expression system His
    Rhesus IL6R-457R Recombinant Rhesus IL6R Protein, His-tagged HEK293 His
    Rhesus monkey IL6R-1559R Recombinant Rhesus Monkey IL6R Protein HEK293 N/A
    Rhesus monkey IL6R-1560R Recombinant Rhesus Monkey IL6R Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey IL6R-1561R Recombinant Rhesus Monkey IL6R Protein, hIgG4-tagged HEK293 hIgG4
    Sus scrofa (Pig) RFL24812SF Recombinant Full Length Pig Interleukin-6 Receptor Subunit Alpha(Il6R) Protein, His-Tagged E.coli expression system His
    Zebrafish IL6R-6383Z Recombinant Zebrafish IL6R Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL6R Related Articles
    • IL6R Related Gene Family
    • IL6R Related Signal Pathway

    IL6R involved in several pathways and played different roles in them. We selected most pathways IL6R participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionIl23a; Il12b;IL10RA;IL11RA2;CXCR3;CXCL3;CCR8;CD40LG;GM10591;IFNA21
    PIK-Akt signaling pathwayG6PC2;VEGFA;EIF4E2;SGK1;PPP2R5A;NFKB1;PTEN;RPS6KB2;G6PC3
    Jak-STAT signaling pathwayPTPN6;SOCS6B;CSF3R;IL3;IL13;LEPB;IL19;PRL;IRX1
    Hematopoietic cell lineageCD8B1;IL3RA;IL1R2;CSF3R;GM13305;CR2;THPO;EPO;CD1E, B2M
    Non-alcoholic fatty liver disease (NAFLD)PIK3R5;TRAF2;PIK3CG;PRKAG1;GSK3B;COX7B2;PRKAG2;PIK3CB;NDUFA7

    IL6R has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6R itself. We selected most functions IL6R had, and list some proteins which have the same functions with IL6R. You can find most of the proteins on our site.

    Function Related Protein
    ciliary neurotrophic factor bindingIl6ra;IL6R
    contributes_to ciliary neurotrophic factor receptor activityCNTFR;Il6ra;IL6R;LIFR
    interleukin-6 bindingIL6R;Il6ra
    contributes_to interleukin-6 receptor activityIL6R;Il6ra;IL6ST
    contributes_to interleukin-6 receptor bindingIL6R;Il6ra;IL6ST;IL6
    protein bindingUSO1;RSPH1;TRAF3;RTN1;GALR1;PRPS1;DCD;GNA14;EIF4E2
    protein homodimerization activityAOC3;KCNN2;CADM1B;TREX1;FASN;IRF3;DMRT3A;DMRTC1B;GGCT

    IL6R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6R.

    IL6; K2; JAK1; ERAP1; Adam17; IL6ST

    Tseng-Rogenski, SS; Hamaya, Y; et al. Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells. GASTROENTEROLOGY 148:579-589(2015).
    Kim, G; Ouzounova, M; et al. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. ONCOGENE 34:671-680(2015).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    What is the dose and route of administration of IL6R? 04/30/2022

    The dose and route of administration need to be determined according to the specific treatment situation. Common routes of administration include subcutaneous injection and intravenous injection.

    Can recombinant IL6R be used in autoimmune diseases? 04/03/2022

    It can be used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.

    Can recombinant IL6R be used to prevent disease? 09/14/2021

    The IL6R is primarily used to treat inflammatory diseases that have already occurred, rather than prevent them.

    How the action mechanism of IL6R? 03/20/2021

    IL6R reduces inflammation by binding to interleukin-6 (IL-6), blocking the IL-6 signaling pathway.

    Does IL6R have anti-tumor effects? 11/06/2020

    Although IL6R can regulate the immune system, it is not a direct anti-tumor drug.

    How to evaluate the efficacy of IL6R? 06/29/2019

    The efficacy of IL6R is usually evaluated based on improvement of clinical symptoms, changes in disease activity, and changes in biochemical markers.

    Customer Reviews (3)

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      The biological function and activity of IL6R were evaluated by cell culture experiment and ELISA. -


        Dual fluorescent protein labeling technique, which assesses protein stability and structure through the interaction between fluorescent inorganic crystals and proteins. -


          Presence and purity of IL6R were analyzed by western blotting in combination with specific antibodies. -

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