IL6R

  • Official Full Name

    interleukin 6 receptor

  • Overview

    his gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
  • Synonyms

    IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; interleukin 6 receptor; IL6R;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Human
  • Macaca mulatta
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus
  • Rhesus monkey
  • Sus scrofa (Pig)
  • Zebrafish
  • CHO
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • SF9 insect cells
  • Wheat Germ
  • Yeast
  • C
  • hFc
  • His
  • Avi
  • Fc
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • His(C
  • ter)
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL6R-201H Active Recombinant Human IL6R, HIgG1 Fc-tagged CHO Fc
Human IL6R-200H Active Recombinant Human IL6R, MIgG2a Fc-tagged CHO Fc
Human IL6R-428H Active Recombinant Human IL6R, His-tagged Mammalian cells His
Human IL6R-051H Active Recombinant Human IL6R protein, His/Avi-tagged, Biotinylated CHO cells His/Avi Leu20-Pro365
Human IL6R-788H Active Recombinant Human IL6R protein (Met1-Pro365), hFc-tagged HEK293 hFc
Human IL6R-1046H Recombinant Human IL6R protein(Met1-Pro365), hFc-tagged HEK293 C-hFc Met1-Pro365
Human IL6R-29271TH Recombinant Human IL6R N/A
Human IL6R-1242H Recombinant Human Interleukin 6 Receptor E.coli N/A
Human IL6R-964H Recombinant Human Interleukin 6 Receptor E.coli N/A
Human IL6R-584H Active Recombinant Human IL6R Protein HEK293 cells N/A
Human IL6R-239H Recombinant Human IL6R, C13&N15-labeled HEK293 N/A
Human IL6R-322H Recombinant Human IL6R, Fc-tagged CHO Fc
Human IL6R-545H Recombinant Human Interleukin 6 Receptor Human N/A
Human IL6R-1241H Recombinant Human Interleukin 6 Receptor, His-tagged E.coli His
Human IL6R-786H Active Recombinant Human IL6R protein, His-tagged HEK293 His Leu20-Pro365
Human IL6R-100H Recombinant Human Interleukin-6 Soluble Receptor,His-tagged E.coli His
Human IL6R-2903HCL Recombinant Human IL6R cell lysate Human Cell N/A
Human IL6R-5174H Recombinant Human IL6R Protein, GST-tagged Wheat Germ GST
Human IL6R-787H Active Recombinant Human IL6R protein, His&Avi-tagged, Biotinylated HEK293 His&Avi Met1-Pro365
Human IL6R-2176H Recombinant Human IL6R Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IL6R-087H Recombinant Human IL6R protein, His-Avi-tagged HEK293 His-Avi It contains Leu 20 - Pro 365.
Human IL6R-2768H Recombinant Human IL6R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL6R-5689HF Recombinant Full Length Human IL6R Protein In Vitro Cell Free System 178 amino acids
Human IL6R-5175H Recombinant Human IL6R Protein Wheat Germ N/A
Human IL6R-3154H-B Recombinant Human IL6R Protein Pre-coupled Magnetic Beads HEK293
Human IL6R-139I Active Recombinant Human IL6R Protein (350 aa), N-His-tagged SF9 insect cells 350
Human IL6R-144H Recombinant Human IL6R Protein, Leu20-Pro365, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Leu20-Pro365
Human IL6R-1058H Recombinant Human IL-6 Protein E.coli N/A
Human IL6R-3154H Recombinant Human IL6R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL6R-3837H Recombinant Human IL6R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL6R-1593H Recombinant Human IL6R Protein (Met1-Pro365), C-His tagged Mammalian cells C-His Met1-Pro365
Human IL6R-1054H Recombinant Human IL6R Protein, His-tagged HEK293F N-His Leu20-Pro365
Human IL6R-5452H Recombinant Human IL6R protein, His-tagged Yeast His 20-365aa
Human IL6R-5692HF Recombinant Full Length Human IL6R Protein, GST-tagged In Vitro Cell Free System GST 468 amino acids
Human IL6R-213H Recombinant Human IL6R Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Leu20-Asp358
Human IL6R-070H Recombinant Human IL6R Protein, C-His-tagged E.coli C-His
Human IL6R-235I Active Recombinant Human IL6R Protein CHO
Human IL6R-335H Recombinant Human IL6R Protein, His-tagged HEK293 His 468
Human IL6R-517H Recombinant Human IL6R Protein, C13 and N15 Labeled 468
Human IL6R-0185H Active Recombinant Human IL6R protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Leu20-Pro365
Human IL6R-0187H Active Recombinant Human IL6R protein, Fc-tagged HEK293 Fc Leu20-Pro365
Human IL6R-1418H Recombinant Human IL6R Protein (Met1-Pro365), N-His tagged E.coli N-His Met1-Pro365
Mouse IL6R-0186M Active Recombinant Mouse IL6R protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu20-Glu357
Rat Il6r-1836R Recombinant Rat Il6r protein, His-tagged E.coli His Ala19~Ala348 (Accession # P25391)
Rat Il6r-9168H Recombinant Rat Il6r, His-tagged HEK293 His 1-357a.a.
Rat Il6r-935R Recombinant Rat Il6r, His-tagged Human Cell His
Rat Il6r-1145R Recombinant Rat Il6r protein(Met1-Pro364), His-tagged HEK293 C-His Met1-Pro364
Rat IL6R-056R Recombinant Rat IL6R protein, hFc-tagged HEK293 hFc Met1-Pro364
Rhesus monkey IL6R-1559R Recombinant Rhesus Monkey IL6R Protein HEK293 N/A
Rhesus monkey IL6R-1560R Recombinant Rhesus Monkey IL6R Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey IL6R-1561R Recombinant Rhesus Monkey IL6R Protein, hIgG4-tagged HEK293 hIgG4
Canine IL6R-1064C Active Recombinant Canine IL6R protein, His-tagged HEK293 His Met1-Pro365
Macaca mulatta IL6R-9166H Recombinant Cynomolgus IL6R, His-tagged HEK293 His
Rattus norvegicus (Rat) RFL7419RF Recombinant Full Length Rat Interleukin-6 Receptor Subunit Alpha(Il6R) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-462)
Rhesus IL6R-457R Active Recombinant Rhesus IL6R Protein, His-tagged HEK293 His Met1-Pro365
Sus scrofa (Pig) RFL24812SF Recombinant Full Length Pig Interleukin-6 Receptor Subunit Alpha(Il6R) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-467)
Zebrafish IL6R-6383Z Recombinant Zebrafish IL6R Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IL6R Related Signal Pathway

IL6R involved in several pathways and played different roles in them. We selected most pathways IL6R participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionKITLGB;LTA;CXCR3.2;CSF3;TNFSF9;Ccl9;CCR1L1;CSF2RB;TGFB2
HIF- signaling pathwayNOX1;ENO3;CAMK2A;HKDC1;SERPINE1;ANGPT2;PRKCA;EPO;IFNGR2
PIK-Akt signaling pathwayPPP2R5D;PKN3;PRKAA1;PIK3R3;RPS6KB2;PPP2CA;LAMA4;IKBKB;FGF11
Jak-STAT signaling pathwayPIK3R3B;IL7;IFNA4;IL21R;LIFRA;IFNAR1;IL2RG;LEPA;IL2RA
Hematopoietic cell lineageFlt3l;CSF1;CD19;CD24;GP5;TNF;CSF3;HLA-DRA;ITGA5
Non-alcoholic fatty liver disease (NAFLD)PRKAB1;NDUFB5;NDUFA6;NDUFB3;ADIPOR1;PIK3CA;RELA;IL6;COX4I2

IL6R has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6R itself. We selected most functions IL6R had, and list some proteins which have the same functions with IL6R. You can find most of the proteins on our site.

Function Related Protein
ciliary neurotrophic factor bindingIl6ra;IL6R
contributes_to ciliary neurotrophic factor receptor activityCNTFR;IL6R;Il6ra;LIFR
enzyme bindingNOXO1;KAT8;PDCD2;PGR;H2AFX;GSTM3;PPP3CB;TOP2A;HSPA8
interleukin-6 bindingIL6R;Il6ra
contributes_to interleukin-6 receptor activityIl6ra;IL6R;IL6ST
contributes_to interleukin-6 receptor bindingIL6R;Il6ra;IL6;IL6ST
protein bindingEXOSC2;CA4;LAMA4;GNAT1;MIS12;PLCB4;ITGB1BP3;YAF2;SNX7
protein homodimerization activityFLNA;EXT1;NDP;DMRT3A;XPNPEP1;BLOC1S6;C16orf89;Flt3l;GCH1

IL6R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6R.

IL6; K2; JAK1; ERAP1; Adam17; IL6ST

Gene Family

IL

Research Area

Related articles

Tseng-Rogenski, SS; Hamaya, Y; et al. Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells. GASTROENTEROLOGY 148:579-589(2015).
Kim, G; Ouzounova, M; et al. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. ONCOGENE 34:671-680(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the dose and route of administration of IL6R? 04/30/2022

The dose and route of administration need to be determined according to the specific treatment situation. Common routes of administration include subcutaneous injection and intravenous injection.

Can recombinant IL6R be used in autoimmune diseases? 04/03/2022

It can be used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.

Can recombinant IL6R be used to prevent disease? 09/14/2021

The IL6R is primarily used to treat inflammatory diseases that have already occurred, rather than prevent them.

How the action mechanism of IL6R? 03/20/2021

IL6R reduces inflammation by binding to interleukin-6 (IL-6), blocking the IL-6 signaling pathway.

Does IL6R have anti-tumor effects? 11/06/2020

Although IL6R can regulate the immune system, it is not a direct anti-tumor drug.

How to evaluate the efficacy of IL6R? 06/29/2019

The efficacy of IL6R is usually evaluated based on improvement of clinical symptoms, changes in disease activity, and changes in biochemical markers.

Customer Reviews (3)

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Reviews
02/23/2022

    Good compatibility and stability with the surfactant.

    11/23/2020

      Expression level and stability of clones were good.

      02/01/2019

        Remarkable antibacterial activity and bactericidal effect on bacteria.

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