IL6R
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Official Full Name
interleukin 6 receptor
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Background
his gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. -
Synonyms
IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; interleukin 6 receptor; IL6R;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL6R Related Articles
- IL6R Related Gene Family
- IL6R Related Signal Pathway
IL6R involved in several pathways and played different roles in them. We selected most pathways IL6R participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | Il23a; Il12b;IL10RA;IL11RA2;CXCR3;CXCL3;CCR8;CD40LG;GM10591;IFNA21 |
| HIF- signaling pathway | PIK3CB;CAMK2G;PDHA2;HMOX1;BCL2;NOX3;IFNGR2;ANGPT4;MAPK1 |
| PIK-Akt signaling pathway | G6PC2;VEGFA;EIF4E2;SGK1;PPP2R5A;NFKB1;PTEN;RPS6KB2;G6PC3 |
| Jak-STAT signaling pathway | PTPN6;SOCS6B;CSF3R;IL3;IL13;LEPB;IL19;PRL;IRX1 |
| Hematopoietic cell lineage | CD8B1;IL3RA;IL1R2;CSF3R;GM13305;CR2;THPO;EPO;CD1E, B2M |
| Non-alcoholic fatty liver disease (NAFLD) | PIK3R5;TRAF2;PIK3CG;PRKAG1;GSK3B;COX7B2;PRKAG2;PIK3CB;NDUFA7 |
IL6R has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6R itself. We selected most functions IL6R had, and list some proteins which have the same functions with IL6R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ciliary neurotrophic factor binding | Il6ra;IL6R |
| contributes_to ciliary neurotrophic factor receptor activity | CNTFR;Il6ra;IL6R;LIFR |
| enzyme binding | CABYR;MLEC;HIST1H2AN;YWHAB;ERN1;PTPLAD1;YES1;HSPA2;HSPA5 |
| interleukin-6 binding | IL6R;Il6ra |
| contributes_to interleukin-6 receptor activity | IL6R;Il6ra;IL6ST |
| contributes_to interleukin-6 receptor binding | IL6R;Il6ra;IL6ST;IL6 |
| protein binding | USO1;RSPH1;TRAF3;RTN1;GALR1;PRPS1;DCD;GNA14;EIF4E2 |
| protein homodimerization activity | AOC3;KCNN2;CADM1B;TREX1;FASN;IRF3;DMRT3A;DMRTC1B;GGCT |
IL6R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6R.
IL6; K2; JAK1; ERAP1; Adam17; IL6ST
- Q&As
- Reviews
Q&As (6)
Ask a questionThe dose and route of administration need to be determined according to the specific treatment situation. Common routes of administration include subcutaneous injection and intravenous injection.
It can be used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.
The IL6R is primarily used to treat inflammatory diseases that have already occurred, rather than prevent them.
IL6R reduces inflammation by binding to interleukin-6 (IL-6), blocking the IL-6 signaling pathway.
Although IL6R can regulate the immune system, it is not a direct anti-tumor drug.
The efficacy of IL6R is usually evaluated based on improvement of clinical symptoms, changes in disease activity, and changes in biochemical markers.
Customer Reviews (3)
Write a reviewThe biological function and activity of IL6R were evaluated by cell culture experiment and ELISA. -
Dual fluorescent protein labeling technique, which assesses protein stability and structure through the interaction between fluorescent inorganic crystals and proteins. -
Presence and purity of IL6R were analyzed by western blotting in combination with specific antibodies. -
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