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Recombinant Human Kinase Insert Domain Receptor (a type III receptor tyrosine kinase), Fc-tagged

Cat.No. : KDR-5442H
Product Overview : Recombinant human KDRwas fused with the Fc part of human IgG1. The recombinant mature KDRis a disulfide-linked homodimeric protein. The KDR monomers have a mass ofapproximately 160 kDa.
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Cat. No. : KDR-5442H
Description : KDR has a lower affinity for VEGF than theFlt-1 receptor, but a higher signaling activity. Mitogenic activity inendothelial cells is mainly mediated by KDR leading to their proliferation.Differential splicing of the flt-1 gene leads to the formation of a secreted,soluble variant of VEGFR-1 (sVEGFR-1). No naturally occurring, secreted formsof KDR have so far been reported. The binding of VEGF165 to KDR is dependenton heparin.
Source : Insect cells
Species : Human
Form : Lyophilized
Molecular Weight : 160 kDa
Purity : > 90%, bySDS-PAGE and visualized by silver stain
Endotoxin Level : < 0.1 ng per ugof KDR
Biological Activity : The activity of KDRwas determined by its ability to inhibit the VEGF-dependent proliferation ofhuman umbilical vein endothelial cells. The ED50 for this effectis typically 10-30 ng/ml.
Reconstitution : The lyophilized KDRis soluble in water and most aqueous buffers. The lyophilized KDR should bereconstituted in PBS or medium to a concentration not lower than 50 ug/ml.
Storage : Lyophilizedsamples are stable for greater than six months at -20°C to -70°C.Reconstituted KDR should be stored in working aliquots at -20°C. Avoidrepeated freeze-thaw cycles.
Gene Name : KDR kinase insert domain receptor (a typeIII receptor tyrosine kinase) [ Homo sapiens ]
Official Symbol : KDR
Synonyms : KDR; kinase insertdomain receptor (a type III receptor tyrosine kinase); FLK1;CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; solubleVEGFR2; OTTHUMP00000158928; fetal liver kinase 1; fetal liver kinase-1;protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factorreceptor
Gene ID : 3791
mRNA Refseq : NM_002253
Protein Refseq : NP_002244
MIM : 191306
UniProt ID : P35968
Chromosome Location : 4q11-q12
Pathway : Cytokine-cytokine receptorinteraction; Endocytosis; Focal adhesion; VEGF signaling pathway; Signalingby VEGF
Function : ATP binding; growth factorbinding; nucleotide binding; receptor activity; transferase activity;vascular endothelial growth factor receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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