Recombinant Human MAPK3

• Cat.No.: MAPK3-28694TH
• Product Overview: Recombinant full-length Human ERK1 with a N terminal proprietary tag; MWt 72 kDa.

Specification

• Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
• Protein length: 379 amino acids
• Molecular Weight: 72.000kDa inclusive of tags
• Source: E. coli
• Biological activity: Specific activity 840 nmol/min/mg.
• Form: Liquid
• Purity: Densitometry
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MAPK3 mitogen-activated protein kinase 3 [ Homo sapiens ]
• Official Symbol: MAPK3
• Synonyms: MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk
• Gene ID: 5595
• mRNA Refseq: NM_001040056
• Protein Refseq: NP_001035145
• MIM: 601795
• Uniprot ID: P27361
• Chromosome Location: 16p11.2
• Pathway: ALK1 signaling events, organism-specific biosystem; ARMS-mediated activation, organism-specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of the AP-1 family of transcription factors, organism-specific biosystem
• Function: ATP binding; MAP kinase activity; MAP kinase activity; nucleotide binding; phosphatase binding