Recombinant Human MLH1 protein, MYC/DDK-tagged
Cat.No. : | MLH1-234H |
Product Overview : | Recombinant Human MLH1 fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 84.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) [ Homo sapiens ] |
Official Symbol : | MLH1 |
Synonyms : | MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); COCA2, mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2); DNA mismatch repair protein Mlh1; FCC2; HNPCC; HNPCC2; COCA2; hMLH1; MGC5172; |
Gene ID : | 4292 |
mRNA Refseq : | NM_000249 |
Protein Refseq : | NP_000240 |
MIM : | 120436 |
UniProt ID : | P40692 |
Chromosome Location : | 3p22.3 |
Pathway : | BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Colorectal cancer, organism-specific biosystem; Colorectal cancer, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Endometrial cancer, organism-specific biosystem; Endometrial cancer, conserved biosystem; Fanconi anemia pathway, organism-specific biosystem; |
Function : | ATP binding; ATPase activity; contributes_to MutSalpha complex binding; guanine/thymine mispair binding; mismatched DNA binding; protein binding; contributes_to protein binding; contributes_to single-stranded DNA binding; |
Products Types
◆ Recombinant Protein | ||
Mlh1-4089M | Recombinant Mouse Mlh1 Protein, Myc/DDK-tagged | +Inquiry |
MLH1-5580M | Recombinant Mouse MLH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MLH1-3357R | Recombinant Rat MLH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MLH1-5385H | Recombinant Human MLH1 Protein, GST-tagged | +Inquiry |
MLH1-1290H | Recombinant Human MLH1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
MLH1-4295HCL | Recombinant Human MLH1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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