Recombinant Human MMP3, His-tagged
Cat.No. : | MMP3-28202TH |
Product Overview : | Full length native protein of Human MMP3. |
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Description : | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. |
Conjugation : | HIS |
Form : | Liquid |
Storage buffer : | The enzyme is supplied as a mixture of the zymogen and active enzyme in:Preservative: 0.01% Sodium AzideConstituents: 50% Glycerol, 0.025% Brij 35, 5mM Calcium chloride, 250mM Sodium chloride, 25mM Tris, pH 7.4 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the peptidase M10A family.Contains 4 hemopexin-like domains. |
Gene Name : | MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Homo sapiens ] |
Official Symbol : | MMP3 |
Synonyms : | MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase) , STMY, STMY1; stromelysin-1; |
Gene ID : | 4314 |
mRNA Refseq : | NM_002422 |
Protein Refseq : | NP_002413 |
Uniprot ID : | P08254 |
Chromosome Location : | 11q22.3 |
Pathway : | Matrix Metalloproteinases, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem; Transcriptional misregulation in cancers, organism-specific biosystem; Transcriptional misregulation in cancers, conserved biosystem; |
Function : | calcium ion binding; metalloendopeptidase activity; peptidase activity; protein complex binding; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
MMP3-1124R | Recombinant Rabbit MMP3 Protein, His-tagged | +Inquiry |
MMP3-0029H | Recombinant Human MMP3 Protein | +Inquiry |
MMP3-2450H | Recombinant Human MMP3 Protein, His-tagged | +Inquiry |
Mmp3-10594M | Recombinant Mouse Mmp3 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP3-2449H | Recombinant Human MMP3 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
MMP3-26C | Native Clostridium histolyticum Collagenase Type 3 Protein | +Inquiry |
◆ Lysates | ||
MMP3-4273HCL | Recombinant Human MMP3 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-0589 | MMP-3 Activity Assay Kit | +Inquiry |
Kit-2213 | MMP-3 Activity Fluorometric Assay Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Q&As (7)
Ask a questionMMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.
MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.
Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.
MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.
MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.
MMP3 modulates inflammation, impacting tissue inflammation and repair processes.
MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.
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