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Recombinant Human MMP3, His-tagged

Cat.No. : MMP3-28202TH
Product Overview : Full length native protein of Human MMP3.
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Description : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Conjugation : HIS
Form : Liquid
Storage buffer : The enzyme is supplied as a mixture of the zymogen and active enzyme in:Preservative: 0.01% Sodium AzideConstituents: 50% Glycerol, 0.025% Brij 35, 5mM Calcium chloride, 250mM Sodium chloride, 25mM Tris, pH 7.4
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the peptidase M10A family.Contains 4 hemopexin-like domains.
Gene Name : MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Homo sapiens ]
Official Symbol : MMP3
Synonyms : MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase) , STMY, STMY1; stromelysin-1;
Gene ID : 4314
mRNA Refseq : NM_002422
Protein Refseq : NP_002413
Uniprot ID : P08254
Chromosome Location : 11q22.3
Pathway : Matrix Metalloproteinases, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem; Transcriptional misregulation in cancers, organism-specific biosystem; Transcriptional misregulation in cancers, conserved biosystem;
Function : calcium ion binding; metalloendopeptidase activity; peptidase activity; protein complex binding; zinc ion binding;

Not For Human Consumption!

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12/05/2020

    Critical expertise in protein engineering, a trusted partner in research.

    03/21/2020

      Swift and reliable protein sequencing, a key asset for our work.

      01/22/2020

        High-quality protein crystallography services, consistently delivers exceptional outcomes.

        Q&As (7)

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        How does MMP3 (Matrix Metalloproteinase 3) facilitate extracellular matrix remodeling? 10/21/2022

        MMP3 breaks down extracellular matrix components, aiding in tissue remodeling and repair.

        What is the impact of MMP3 on cancer metastasis and tumor microenvironment modulation? 07/04/2022

        MMP3 facilitates cancer metastasis by altering the tumor microenvironment and promoting invasion.

        How do alterations in MMP3 expression or activity affect skin aging and the development of dermatological conditions? 10/19/2021

        Changes in MMP3 activity can accelerate skin aging and contribute to dermatological conditions.

        How does MMP3 influence cardiovascular diseases, particularly in atherosclerosis and aneurysm formation? 07/01/2021

        MMP3 influences cardiovascular health by affecting arterial wall remodeling and stability.

        What role does MMP3 play in the progression of arthritis and joint degeneration? 09/03/2019

        MMP3 contributes to arthritis progression by degrading joint cartilage and connective tissues.

        What are the mechanisms by which MMP3 modulates inflammatory responses? 06/13/2019

        MMP3 modulates inflammation, impacting tissue inflammation and repair processes.

        How does MMP3 contribute to wound healing and tissue repair processes? 12/31/2018

        MMP3 plays a role in wound healing by remodeling damaged tissues and aiding in repair.

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