| Description : |
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. |
| Source : |
HEK293 |
| Species : |
Human |
| Form : |
Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2. |
| Molecular Mass : |
35.0 kDa |
| Protein length : |
Gln31-Thr334 |
| Purity : |
>95% as determined by SDS-PAGE and Coomassie blue staining |
| Storage : |
Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
| Concentration : |
Resuspend the protein to the desired concentration in proper buffer. |
