Recombinant Human NECTIN1 protein

Species :	Human
Source :	HEK293
Tag :	Non
Protein Length :	Gln31-Thr334
Description :	This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Form :	Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2.
Molecular Mass :	35.0 kDa
Purity :	>95% as determined by SDS-PAGE and Coomassie blue staining
Storage :	Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Concentration :	Resuspend the protein to the desired concentration in proper buffer.

Gene Name	NECTIN1 nectin cell adhesion molecule 1 [ Homo sapiens ]
Official Symbol	NECTIN1
Synonyms	ED4; PRR; HIgR; HV1S; HVEC; OFC7; PRR1; PVRR; CD111; PVRL1; PVRR1; SK-12; CLPED1; nectin-1
Gene ID	5818
mRNA Refseq	NM_002855
Protein Refseq	NP_002846
MIM	600644
UniProt ID	Q15223