Recombinant Human NECTIN1 protein

• Cat.No.: NECTIN1-223H
• Product Overview: Recombinant Human NECTIN1(Gln31-Thr334), transcript variant 1, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Protein Length: Gln31-Thr334
• Description: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2.
• Molecular Mass: 35.0 kDa
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Storage: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Concentration: Resuspend the protein to the desired concentration in proper buffer.

Gene Information

• Gene Name: NECTIN1 nectin cell adhesion molecule 1 [ Homo sapiens ]
• Official Symbol: NECTIN1
• Synonyms: ED4; PRR; HIgR; HV1S; HVEC; OFC7; PRR1; PVRR; CD111; PVRL1; PVRR1; SK-12; CLPED1; nectin-1
• Gene ID: 5818
• mRNA Refseq: NM_002855
• Protein Refseq: NP_002846
• MIM: 600644
• UniProt ID: Q15223