Recombinant Human PADI4 Protein, His-tagged
Cat.No. : | PADI4-114H |
Product Overview : | Active recombinant N-terminal His-tagged full length human PAD4 protein (2-663) was expressed in E. coli. |
- Specification
- Gene Information
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Description : | This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 75.8 kDa |
Protein length : | 2-663 |
Purity : | ≥85% estimated by SDS-PAGE |
Unit Definition : | One unit is defined as the amount of enzyme required to produce 1 nmol of NH4+ per minute at 37 centigrade in 50 mM HEPES, pH 7.7, containing 10 mM calcium chloride, 5 mM DTT, and 2 mM N-Benzoyl-L-Arginine Ethyl Ester (BAEE). |
Stability : | ≥ 2 year |
Storage : | At -80 centigrade. |
Storage Buffer : | 50 mM HEPES, pH 8.0, containing 300 mM sodium chloride, 1 mM DTT, and 10% glycerol |
Gene Name : | PADI4 peptidyl arginine deiminase 4 [ Homo sapiens (human) ] |
Official Symbol : | PADI4 |
Synonyms : | PADI4; peptidyl arginine deiminase 4; PAD; PAD4; PDI4; PDI5; PADI5; protein-arginine deiminase type-4; HL-60 PAD; PADI-H protein; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; protein-arginine deiminase type IV; EC 3.5.3.15 |
Gene ID : | 23569 |
mRNA Refseq : | NM_012387 |
Protein Refseq : | NP_036519 |
MIM : | 605347 |
UniProt ID : | Q9UM07 |
Products Types
◆ Recombinant Protein | ||
PADI4-037H | Recombinant Human PADI4 Protein, His/GST-tagged | +Inquiry |
PADI4-203H | Recombinant Human PADI4 Protein, MYC/DDK-tagged | +Inquiry |
PADI4-020H | Recombinant Human PADI4 Protein, His-tagged | +Inquiry |
PADI4-0218H | Recombinant Human PADI4 Protein (A2-P663), Tag Free | +Inquiry |
PADI4-313H | Recombinant Human PADI4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PADI4-630HCL | Recombinant Human PADI4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionPADI4 is predominantly expressed in various tissues, including synovial tissues, immune cells, and certain epithelial cells.
PADI4 plays a crucial role in citrullination, a process that converts arginine residues to citrulline, influencing protein structure and function.
Peptidyl arginine deiminase 4 (PADI4) primarily functions in cellular processes, contributing to the post-translational modification of proteins through citrullination.
In the regulation of immune responses, PADI4 is implicated in autoimmune diseases such as rheumatoid arthritis, where it contributes to autoantibody generation.
Dysregulation or abnormal expression of PADI4 is associated with autoimmune disorders, particularly rheumatoid arthritis.
There are potential therapeutic implications related to targeting PADI4 in autoimmune disorders, making it a focus for drug development.
Specific substrates of PADI4 include histones and other proteins, impacting cellular processes like gene regulation and signaling pathways.
Customer Reviews (3)
Write a reviewThe minimal variation across different batches enhanced the repeatability of our results.
The product's role in promoting collaboration and teamwork positively impacted the quality of our research.
The product's compatibility with various instruments and techniques promoted teamwork in our interdisciplinary projects.
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