Recombinant Human PCSK9 Protein, His-tagged PCSK9-005H

Recombinant Human PCSK9 Protein, His-tagged

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Recombinant Human PCSK9 Protein, His-tagged

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Cat.No. : PCSK9-005H
Product Overview : Recombinant Human PCSK9 protein (31-692) with a N-terminal His-tag was expressed in HEK293 overexpression system
Description : This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : His
Bio-activity : Qualitative biological assay-reduces uptake of LDL-DyLight™ by >30% in Huh7 cells at concentrations above 5 µg/ml
Molecular Mass : 71 kDa
Protein length : 31-692
Purity : ≥90% estimated by SDS-PAGE
Stability : ≥ 274 days
Storage : -20 centigrade
Storage Buffer : Lyophilized from PBS, pH 7.4, with 30% sucrose
Shipping : Wet ice in continental US, may vary elsewhere.
SDS-PAGE Analysis of PCSK9 :

Lane 1: MW Markers
Lane 2: PCSK9 (1 µg)
Lane 3: PCSK9 (2 µg)

PCSK9 inhibits LDL uptake :

On four separate plates Huh7 cells were plated and treated with or without 5 µg/ml PCSK9 in media. Sixteen hours later, LDL-DyLight™ 488 was added. After a four-hour incubation the cells were washed, trypsanized, and analyzed by flow cytometry.

Gene Name : PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens (human) ]
Official Symbol : PCSK9
Synonyms : PCSK9; proprotein convertase subtilisin/kexin type 9; FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; proprotein convertase subtilisin/kexin type 9; convertase subtilisin/kexin type 9 preproprotein; neural apoptosis regulated convertase 1; subtilisin/kexin-like protease PC9; EC 3.4.21.
Gene ID : 255738
mRNA Refseq : NM_174936
Protein Refseq : NP_777596
MIM : 607786
UniProt ID : Q8NBP7

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