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Recombinant Human PIK3R1, His-tagged

Cat.No. : PIK3R1-1079H
Product Overview : Recombinant full-length mouse p110alpha and human p85alpha were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.
  • Specification
  • Gene Information
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Description : Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.?
Source : Sf9 insect cells
Species : Human
Tag : His
Form : Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 2mM DTT, 25% glycerol.
Molecular Mass : ~111 kDa (p110α), ~86 kDa (p85α)
Protein length : Full Length
Purity : >90%
Applications : Kinase Assay; Western Blot
Stability : 1 yr at -70oC from date of shipment.
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens (human) ]
Official Symbol : PIK3R1
Synonyms : PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); p85; GRB1; p85-ALPHA; phosphatidylinositol 3-kinase regulatory subunit alpha; OTTHUMP00000161918; OTTHUMP00000161919; OTTHUMP00000161920; OTTHUMP00000226152; OTTHUMP00000226159; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase-associated p-85 alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Gene ID : 5295
mRNA Refseq : NM_181523
Protein Refseq : NP_852664
MIM : 171833
UniProt ID : P27986
Chromosome Location : 5q13.1
Pathway : AMPK signaling; Acute myeloid leukemia; B Cell Receptor Signaling Pathway
Function : ErbB-3 class receptor binding; insulin receptor binding; insulin-like growth factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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