Recombinant Human PIP4K2B Protein (S2-T416), His tagged

• Cat.No.: PIP4K2B-0807H
• Product Overview: Recombinant Human 6His-TEV-GG-PIP4K2B(S2-T416 end) Protein was expressed in E. coli.

Specification

• Description: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: S2-T416
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta [ Homo sapiens (human) ]
• Official Symbol: PIP4K2B
• Synonyms: PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; phosphatidylinositol 4 phosphate 5 kinase, type II, beta, PIP5K2B; phosphatidylinositol-5-phosphate 4-kinase type-2 beta; PIP5KIIB; PIP5KIIbeta; PIP4KII-beta; PTDINS(4)P-5-kinase; PI(5)P 4-kinase type II beta; diphosphoinositide kinase 2-beta; ptdIns(5)P-4-kinase isoform 2-beta; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; PI5P4KB; PIP5K2B
• Gene ID: 8396
• mRNA Refseq: NM_003559
• Protein Refseq: NP_003550
• MIM: 603261
• UniProt ID: P78356