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Recombinant Human PMEL protein, MYC/DDK-tagged

Cat.No. : PMEL-190H
Product Overview : Recombinant Human PMEL fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 70.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : PMEL premelanosome protein [ Homo sapiens ]
Official Symbol : PMEL
Synonyms : PMEL; premelanosome protein; SIL, SILV, silver (mouse homolog) like , silver homolog (mouse); melanocyte protein PMEL; D12S53E; gp100; Pmel17; SI; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100; P1; SIL; ME20; P100; SILV; ME20M; ME20-M; PMEL17;
Gene ID : 6490
mRNA Refseq : NM_006928
Protein Refseq : NP_008859
MIM : 155550
UniProt ID : P40967

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (4)

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Do you offer PMEL fused with other tags? 03/12/2022

We will provide you with the most suitable labels according to your needs.

What are the consequences of PMEL gene deletion? 11/12/2021

Animals with PMEL gene deletions exhibit varying degrees of hyperpigmentation.

What are the main physiological processes in which PMEL proteins are involved? 07/01/2021

PMEL proteins play an important role in melanin synthesis and storage.

In what tissue of the duck is the PMEL protein primarily expressed? 04/11/2021

PMEL proteins are predominantly expressed in the hair follicles and skin of ducks.

Customer Reviews (3)

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Reviews
08/16/2022

    Your company offers a one-stop shop and the process from purchase to receipt of the protein was very smooth!

    07/14/2022

      The purchased PMEL protein is suitable for WB experiments and I am satisfied with the results.

      10/22/2020

        Friendly customer service and detailed answers to all the questions I asked!

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