Recombinant Human PMEL protein, MYC/DDK-tagged PMEL-190H

Recombinant Human PMEL protein, MYC/DDK-tagged


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Recombinant Human PMEL protein, MYC/DDK-tagged

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Cat.No. : PMEL-190H
Product Overview : Recombinant Human PMEL fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description : This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 70.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Figure :

Gene Name : PMEL premelanosome protein [ Homo sapiens ]
Official Symbol : PMEL
Synonyms : PMEL; premelanosome protein; SIL, SILV, silver (mouse homolog) like , silver homolog (mouse); melanocyte protein PMEL; D12S53E; gp100; Pmel17; SI; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100; P1; SIL; ME20; P100; SILV; ME20M; ME20-M; PMEL17;
Gene ID : 6490
mRNA Refseq : NM_006928
Protein Refseq : NP_008859
MIM : 155550
UniProt ID : P40967

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