Recombinant Human PROM1, MYC/DDK-tagged
Cat.No. : | PROM1-45H |
Product Overview : | Recombinant Human PROM1, transcript variant 1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | HEK293 cells |
Species : | Human |
Tag : | MYC/DDK |
Molecular Mass : | 97 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | PROM1 prominin 1 [ Homo sapiens (human) ] |
Official Symbol : | PROM1 |
Synonyms : | prominin 1; prominin (mouse)-like 1; AC133; Stargardt disease 4 (autosomal dominant); CD133; OTTHUMP00000217744; RP41; OTTHUMP00000217745; PROML1; OTTHUMP00000217746; Antigen AC133; hProminin; Prominin-like protein 1; hematopoietic stem cell antigen; CORD12; prominin-1; MCDR2; prominin-like 1; STGD4; CD133 antigen; macular dystrophy, retinal 2; MSTP061; PROM1 |
Gene ID : | 8842 |
mRNA Refseq : | NM_006017 |
Protein Refseq : | NP_006008 |
MIM : | 604365 |
UniProt ID : | O43490 |
Chromosome Location : | 4p15.32 |
Function : | actinin binding; cadherin binding; protein binding |
Products Types
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PROM1-161H | Recombinant Human PROM1 Protein, C-His-tagged | +Inquiry |
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◆ Lysates | ||
PROM1-981RCL | Recombinant Rat PROM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
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Q&As (5)
Ask a questionYes, PROM1's role is widely studied in various cancers, including brain, breast, colon, and pancreatic cancers.
Various laboratory techniques, such as flow cytometry, immunohistochemistry, and molecular biology assays, are employed to study PROM1 expression and function.
No, PROM1 is also associated with certain eye disorders and is being researched for potential applications in retinal diseases.
Research suggests that it could be a target for treatments aimed at eliminating cancer stem cells and potentially preventing cancer relapse.
The potential impact on normal stem cells and unintended consequences on healthy tissues are areas of concern when targeting PROM1 for therapies.
Customer Reviews (3)
Write a reviewThey can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.
Manufacturers can support researchers in developing assays to measure PROM1 protein levels or activity specific to their clinical trial settings.
This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.
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