PROM1
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Official Full Name
prominin 1 -
Overview
CD133 (also known as Prominin-1 or AC133) is a 120 kD pentaspan glycoprotein with 5 transmembrane domains which localize to cellular protrusions. CD133 was initially described as a surface antigen specific for human hematopoietic stem cells and as a marke -
Synonyms
PROM1;prominin 1;prominin-1;prominin-like 1;antigen AC133 homolog;prominin-like protein 1;Prom;AC133;CD133;Prom-1;Proml1;4932416E19Rik
Recombinant Proteins
- Rat
- Human
- Rhesus macaque
- Chicken
- Mouse
- HEK293
- Wheat Germ
- Human Cells
- Mammalian Cells
- E.coli
- Yeast
- In Vitro Cell Free System
- Fc
- Non
- His
- Avi
- GST
- mFc
- Flag
- DDK
- Myc
- SUMO
Involved Pathway
PROM1 involved in several pathways and played different roles in them. We selected most pathways PROM1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | SPINT1,SUPT3H,SP1,DEFA3,ITGB7,ASPSCR1,SMAD1,RXRB,MEF2C,Pdgfa&Pdgfb |
Protein Function
PROM1 has several biochemical functions, for example, actinin binding,cadherin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PROM1 itself. We selected most functions PROM1 had, and list some proteins which have the same functions with PROM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FBN1,KIAA0141,COMMD3,RASSF1,FAP,FAF2,ECH1,SOX9,STYX,SFMBT1 |
| cadherin binding | VCL,FER,OLFM4,CTNND1,JUPA,CTNNB1,NUMB,P2RX4,CTNNA1,PSEN1 |
| actinin binding | CSRP3,RELA,TTN,PDLIM5,MICALL2,PKD2,NFKB1 |
Interacting Protein
PROM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROM1.
ACTB;Actb;Cdhr1;PLEKHA5
Resources
Research Area
Hemangioblast MarkersColon Cancer Stem Cell Markers
Melanoma Cancer Stem Cell Markers
Breast Cancer Stem Cell Markers
Glioma/Medulloblastoma Cancer Stem Cell Markers
Mesodermal Lineage Markers
CAR-T Cell Therapy Targets
Related Services
Related Products
References
- Olausson, KH; Maire, CL; et al. Prominin-1 (CD133) Defines Both Stem and Non-Stem Cell Populations in CNS Development and Gliomas. PLOS ONE 9:-(2014).
- Gopisetty, G; Xu, J; et al. Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation. ONCOGENE 32:3119-3129(2013).
