Recombinant Human PZP Protein (472-821 aa), GST-tagged

• Cat.No.: PZP-1498H
• Product Overview: Recombinant Human PZP Protein (472-821 aa) is produced by Yeast expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Neuroscience. Protein Description: Partial.

Specification

• Description: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme rains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
• Source: Yeast
• Species: Human
• Tag: GST
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 65.3 kDa
• Protein length: 472-821 aa
• AA Sequence: MKPEAELSVSSVYNLLTVKDLTNFP DNVDQQEEEQGHCPRPFFIHNGAIY VPLSSNEADIYSFLKGMGLKVFTNS KIRKPKSCSVIPSVSAGAVGQGYYG AGLGVVERPYVPQLGTYNVIPLNNE QSSGPVPETVRSYFPETWIWELVAV NSSGVAEVGVTVPDTITEWKAGAFC LSEDAGLGISSTASLRAFQPFFVEL TMPYSVIRGEVFTLKATVLNYLPKC IRAEGIEQEKTFSSMTCASGANVSE QLSLKLPSNVVKESARASFSVLGDI LGSAMQNIQNLLQMPYGCGEQNMVL FAPNIYVLNYLNETQQLTQEIKAKA VGYLITGYQRQLNYKHQDGSYSTFG
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: PZP PZP alpha-2-macroglobulin like [ Homo sapiens (human) ]
• Official Symbol: PZP
• Synonyms: CPAMD6
• Gene ID: 5858
• UniProt ID: P20742