Recombinant Human RUVBL1, His-tagged

• Cat.No.: RUVBL1-30681TH
• Product Overview: Recombinant full length Human TIP49A with an N terminal His tag; 476 amino acids ; predicted mwt: 52.3 kDa.

Specification

• Description: RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene. RUVBL1 can form a hexamer. The hexamer can form a dodecamer with RUVBL2 protein.
• Protein length: 456 amino acids
• Conjugation: HIS
• Molecular Weight: 52.300kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Ubiquitously expressed with high expression in heart, skeletal muscle and testis.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.2M Sodium chloride, 5mM DTT, 20mM Tris HCl, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMKIEE VKSTTKTQRIASHSHVKGLGLDESG LAKQAASGLVGQENAREACGVIVEL IKSKKMAGRAVLLAGPPGTGKTALA LAIAQELGSKVPFCPMVGSEVYSTE IKKTEVLMENFRRAIGLRIKETKEV YEGEVTELTPCETENPMGGYGKTIS HVIIGLKTAKGTKQLKLDPSIFESL QKERVEAGDVIYIEANSGAVKRQGR CDTYATEFDLEAEEYVPLPKGDVHK KKEIIQDVTLHDLDVANARPQGGQD ILSMMGQLMKPKKTEITDKLRGEIN KVVNKYIDQGIAELVPGVLFVDEVH MLDIECFTYLHRALESSIAPIVIFA SNRGNCVIRGTEDITSPHGIPLDLL DRVMIIRTMLYTPQEMKQIIKIRAQ TEGINISEEALNHLGEIGTKTTLRY SVQLLTPANLLAKINGKDSIEKEHV EEISELFYDAKSSAKILADQQDKYM K
• Sequence Similarities: Belongs to the ruvB family.

Gene Information

• Gene Name: RUVBL1 RuvB-like 1 (E. coli) [ Homo sapiens ]
• Official Symbol: RUVBL1
• Synonyms: RUVBL1; RuvB-like 1 (E. coli); RuvB (E coli homolog) like 1; ruvB-like 1; ECP54; INO80 complex subunit H; INO80H; NMP238; pontin; Pontin52; RVB1; Rvb1; TIH1; TIP49; TIP49a
• Gene ID: 8607
• mRNA Refseq: NM_003707
• Protein Refseq: NP_003698
• MIM: 603449
• Uniprot ID: Q9Y265
• Chromosome Location: 3q21
• Pathway: C-MYC pathway, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem; Extension of Telomeres, organism-specific biosystem; Nucleosome assembly, organism-specific biosystem
• Function: ATP binding; NOT ATPase activity; DNA helicase activity; hydrolase activity; nucleotide binding