| Description : |
Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis, intestine, tongue, and lung. Recently Maspin received a great deal of attention due to its potential apoptotic role in cancers. Maspin expression predicts a better prognosis for several types of carcinomas including breast, prostate, colon, and oral squamus cell carcinoma. The level of Maspin is also inversely correlated to VEGF-A, an angiogenic factor. Researchers found that Maspin may play its apoptotic role as an endogenous inhibitor of histone deacetylase I (HDAC I). Therefore, Maspin is a potential personalized marker of Non-Small Cell Lung Carcinoma (NSCLC). |
| Source : |
E. coli |
| Species : |
Human |
| Form : |
Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : |
Data not available. |
| Molecular Mass : |
42.1 kDa, observed by reducing SDS-PAGE. |
| Protein Length : |
375 |
| AA Sequence : |
MDALQLANSAFAVDLFKQLCEKEPL GNVLFSPICLSTSLSLAQVGAKGDT ANEIGQVLHFENVKDIPFGFQTVTS DVNKLSSFYSLKLIKRLYVDKSLNL STEFISSTKRPYAKELETVDFKDKL EETKGQINNSIKDLTDGHFENILAD NSVNDQTKILVVNAAYFVGKWMKKF PESETKECPFRLNKTDTKPVQMMNM EATFCMGNIDSINCKIIELPFQNKH LSMFILLPKDVEDESTGLEKIEKQL NSESLSQWTNPSTMANAKVKLSIPK FKVEKMIDPKACLENLGLKHIFSED TSDFSGMSETKGVALSNVIHKVCLE ITEDGGDSIEVPGARILQHKDELNA DHPFIYIIRHNKTRNIIFFGKFCSP |
| Endotoxin : |
< 0.2 EU/μg, determined by LAL method. |
| Purity : |
> 95% by SDS-PAGE and HPLC analysis. |
| Storage : |
Lyophilized recombinant human Maspin (rhMaspin) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rhMaspin remains stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade. |
| Storage Buffer : |
Lyophilized after extensive dialysis against PBS. |
| Reconstitution : |
Reconstituted in ddH2O at 100 μg/mL. |
