Recombinant Human SIK1 protein, His-tagged

Cat.No. : SIK1-432H
Product Overview : Recombinant Human SIK1(1-350aa) fused with His tag was expressed in E. coli.
Availability July 18, 2024
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Description : SIK1 played an important role in many functions.
Source : E. coli
Species : Human
Tag : His
Form : Protein lyophilized in sterile PBS (58 mM Na2HPO4, 17 mM NaH2PO4, 68 mM NaCl, 300 mM Imidazole, pH 8.0). Trehalose (5-8%) and 10% glycerol.
AA Sequence : MVIMSEFSADPAGQGQGQQKPLRVG FYDIERTLGKGNFAVVKLARHRVTK TQVAIKIIDKTRLDSSNLEKIYREV QLMKLLNHPHIIKLYQVMETKDMLY IVTEFAKNGEMFDYLTSNGHLSENE ARKKFWQILSAVEYCHDHHIVHRDL KTENLLLDGNMDIKLADFGFGNFYK SGEPLSTWCGSPPYAAPEVFEGKEY EGPQLDIWSLGVVLYVLVCGSLPFD GPNLPTLRQRVLEGRFRIPFFMSQD CESLIRRMLVVDPARRITIAQIRQH RWMRAEPCLPGPACPAFSAHSYTSN LGDYDEQALGIMQTLGVDRQRTVES LQNSSYNHFAAIYYLLLERLKEYRN
Stability : Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months. Avoid freeze thaw cycles.
Gene Name : SIK1 salt-inducible kinase 1 [ Homo sapiens ]
Official Symbol : SIK1
Synonyms : SIK1; salt-inducible kinase 1; SNF1 like kinase , SNF1LK; serine/threonine-protein kinase SIK1; msk; myocardial SNF1 like kinase; SIK-1; SNF1-like kinase; myocardial SNF1-like kinase; salt-inducible protein kinase 1; serine/threonine protein kinase; serine/threonine-protein kinase SNF1LK; serine/threonine-protein kinase SNF1-like kinase 1; MSK; SIK; SNF1LK;
Gene ID : 150094
mRNA Refseq : NM_173354
Protein Refseq : NP_775490
MIM : 605705
UniProt ID : P57059
Chromosome Location : 21q22.3
Pathway : LKB1 signaling events, organism-specific biosystem;
Function : 14-3-3 protein binding; ATP binding; ATP binding; cAMP response element binding protein binding; magnesium ion binding; magnesium ion binding; nucleotide binding; protein binding; protein kinase binding; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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08/14/2021

    Our lab swears by this product! It's a versatile and reliable tool for our experiments.

    06/05/2019

      The quality control is evident in the data precision we achieve.

      12/09/2018

        As a researcher, I can't live without this product. Makes my experiments more accurate and efficient.

        Q&As (5)

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        What is the significance of SIK1 dysregulation in the context of cancer, and how does it impact cell proliferation and survival? 02/08/2022

        Dysregulation of SIK1 has been implicated in cancer. It can influence cell proliferation and survival by affecting the activity of transcription factors involved in cell cycle control and apoptosis.

        How does SIK1 contribute to the regulation of adipose tissue metabolism, and what implications does this have for metabolic disorders? 12/13/2021

        SIK1 plays a role in adipose tissue metabolism by modulating the activity of transcription factors involved in lipogenesis and lipolysis. Dysregulation may contribute to metabolic disorders like obesity and insulin resistance.

        What is the primary function of the SIK1 protein in cellular processes? 11/04/2020

        SIK1, or Salt-Inducible Kinase 1, is involved in the regulation of cellular responses to various stimuli, including stress, metabolism, and inflammation.

        How does SIK1 participate in cellular energy homeostasis, and what are its downstream targets in metabolic pathways? 04/19/2019

        SIK1 regulates energy homeostasis by phosphorylating and modulating the activity of key metabolic regulators, such as cAMP response element-binding protein (CREB) and class IIa histone deacetylases.

        How does SIK1 contribute to cellular responses to environmental stress, and what are the molecular mechanisms involved in stress signaling pathways? 08/22/2018

        SIK1 is activated in response to environmental stressors, such as osmotic stress. It regulates stress signaling pathways through the phosphorylation of downstream effectors, modulating cellular stress responses.

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