Recombinant Human TBK1 Protein, His-tagged

• Cat.No.: TBK1-117H
• Product Overview: Recombinant Human TBK1 Protein, fused to His-tag, was expressed in E.coli.

Specification

• Description: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Supplied as a 0.2 μm filtered solution in PBS pH8.0.
• Molecular Mass: ~87.1 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMASMT GGQQMGRGSMQSTSNHLWLLSDILG QGATANVFRGRHKKTGDLFAIKVFN NISFLRPVDVQMREFEVLKKLNHKN IVKLFAIEEETTTRHKVLIMEFCPC GSLYTVLEEPSNAYGLPESEFLIVL RDVVGGMNHLRENGIVHRDIKPGNI MRVIGEDGQSVYKLTDFGAARELED DEQFVSLYGTEEYLHPDMYERAVLR KDHQKKYGATVDLWSIGVTFYHAAT GSLPFRPFEGPRRNKEVMYKIITGK PSGAISGVQKAENGPIDWSGDMPVS CSLSRGLQVLLTPVLANILEADQEK CWGFDQFFAETSDILHRMVIHVFSL QQMTAHKIYIHSYNTATIFHELVYK QTKIISSNQELIYEGRRLVLEPGRL AQHFPKTTEENPIFVVSREPLNTIG LIYEKISLPKVHPRYDLDGDASMAK AITGVVCYACRIASTLLLYQELMRK GIRWLIELIKDDYNETVHKKTEVVI TLDFCIRNIEKTVKVYEKLMKINLE AAELGEISDIHTKLLRLSSSQGTIE TSLQDIDSRLSPGGSLADAWAHQEG THPKDRNVEKLQVLLNCMTEIYYQF KKDKAERRLAYNEEQIHKFDKQKLY YHATKAMTHFTDECVKKYEAFLNKS EEWIRKMLHLRKQLLSLTNQCFDIE EEVSKYQEYTNELQETLPQKMFTAS SGIKHTMTPIYPSSNTLVEMTLGMK KLKEEMEGVVKELAENNHILERFGS LTMDGGLRNVDCL
• Purity: >70%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.025 mg/ml

Gene Information

• Gene Name: TBK1 TANK binding kinase 1 [ Homo sapiens (human) ]
• Official Symbol: TBK1
• Synonyms: NAK; T2K; IIAE8; FTDALS4
• Gene ID: 29110
• mRNA Refseq: NM_013254
• Protein Refseq: NP_037386
• MIM: 604834
• UniProt ID: Q9UHD2