Recombinant Human TPMT Protein (Leu26-His227), His tagged

• Cat.No.: TPMT-6503H
• Product Overview: Recombinant human TPMT (Leu26-His227) fused with His tag was expressed in E. coli.

Specification

• Description: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 23.89 kDa
• Protein Length: Leu26-His227
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: TPMT thiopurine S-methyltransferase [ Homo sapiens (human) ]
• Official Symbol: TPMT
• Synonyms: TPMT; thiopurine S-methyltransferase; S-adenosyl-L-methionine:thiopurine S-methyltransferase
• Gene ID: 7172
• mRNA Refseq: NM_000367
• Protein Refseq: NP_000358
• MIM: 187680
• UniProt ID: P51580