Recombinant Human USP13 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | USP13-2648H |
Product Overview : | USP13 MS Standard C13 and N15-labeled recombinant protein (NP_003931) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 97.3 kDa |
AA Sequence : | MQRRGALFGMPGGSGGRKMAAGDIG ELLVPHMPTIRVPRSGDRVYKNECA FSYDSPNSEGGLYVCMNTFLAFGRE HVERHFRKTGQSVYMHLKRHVREKV RGASGGALPKRRNSKIFLDLDTDDD LNSDDYEYEDEAKLVIFPDHYEIAL PNIEELPALVTIACDAVLSSKSPYR KQDPDTWENELPVSKYANNLTQLDN GVRIPPSGWKCARCDLRENLWLNLT DGSVLCGKWFFDSSGGNGHALEHYR DMGYPLAVKLGTITPDGADVYSFQE EEPVLDPHLAKHLAHFGIDMLHMHG TENGLQDNDIKLRVSEWEVIQESGT KLKPMYGPGYTGLKNLGNSCYLSSV MQAIFSIPEFQRAYVGNLPRIFDYS PLDPTQDFNTQMTKLGHGLLSGQYS KPPVKSELIEQVMKEEHKPQQNGIS PRMFKAFVSKSHPEFSSNRQQDAQE FFLHLVNLVERNRIGSENPSDVFRF LVEERIQCCQTRKVRYTERVDYLMQ LPVAMEAATNKDELIAYELTRREAE ANRRPLPELVRAKIPFSACLQAFSE PENVDDFWSSALQAKSAGVKTSRFA SFPEYLVVQIKKFTFGLDWVPKKFD VSIDMPDLLDINHLRARGLQPGEEE LPDISPPIVIPDDSKDRLMNQLIDP SDIDESSVMQLAEMGFPLEACRKAV YFTGNMGAEVAFNWIIVHMEEPDFA EPLTMPGYGGAASAGASVFGASGLD NQPPEEIVAIITSMGFQRNQAIQAL RATNNNLERALDWIFSHPEFEEDSD FVIEMENNANANIISEAKPEGPRVK DGSGTYELFAFISHMGTSTMSGHYI CHIKKEGRWVIYNDHKVCASERPPK DLGYMYFYRRIPSTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | USP13 ubiquitin specific peptidase 13 [ Homo sapiens (human) ] |
Official Symbol : | USP13 |
Synonyms : | USP13; ubiquitin specific peptidase 13 (isopeptidase T-3); ubiquitin specific protease 13 (isopeptidase T 3); ubiquitin carboxyl-terminal hydrolase 13; IsoT 3; isopeptidase T-3; ubiquitin thioesterase 13; deubiquitinating enzyme 13; ubiquitin thiolesterase 13; ubiquitin-specific-processing protease 13; ubiquitin specific protease 13 (isopeptidase T-3); ISOT3; IsoT-3; |
Gene ID : | 8975 |
mRNA Refseq : | NM_003940 |
Protein Refseq : | NP_003931 |
MIM : | 603591 |
UniProt ID : | Q92995 |
Products Types
◆ Recombinant Protein | ||
USP13-2649H | Recombinant Human USP13 Protein, Myc/DDK-tagged | +Inquiry |
USP13-9949M | Recombinant Mouse USP13 Protein, His (Fc)-Avi-tagged | +Inquiry |
USP13-0352H | Recombinant Human USP13 Protein (Q2-S863), GST tagged | +Inquiry |
USP13-4933R | Recombinant Rhesus Macaque USP13 Protein, His (Fc)-Avi-tagged | +Inquiry |
USP13-0351H | Recombinant Human USP13 Protein (Q2-S863), Tag Free | +Inquiry |
◆ Lysates | ||
USP13-472HCL | Recombinant Human USP13 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionThere is emerging research suggesting that USP13 may play a role in neurodegenerative diseases, and targeting it could be a potential avenue for therapeutic intervention.
USP13 interacts with various proteins, forming complexes that regulate different cellular pathways. Understanding these interactions is crucial for deciphering its role in health and disease.
Genetic variations in the USP13 gene have been studied, and certain polymorphisms may be associated with an increased risk of specific diseases. Further research is ongoing in this area.
Researchers are exploring the role of USP13 in neurodegenerative diseases, inflammatory disorders, and other conditions where ubiquitin-mediated processes play a crucial role.
USP13 has been found to regulate the stability of proteins involved in the DNA damage response, affecting how cells respond to stress and maintain genomic integrity.
Customer Reviews (3)
Write a reviewIts purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.
Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.
Whether it's troubleshooting, protocol optimization, or general inquiries, their knowledgeable and responsive team is readily available to assist and solve any problems that may arise during the experimental process.
Ask a Question for All USP13 Products
Required fields are marked with *
My Review for All USP13 Products
Required fields are marked with *
Inquiry Basket