| Species : |
Human |
| Source : |
E.coli |
| Tag : |
His |
| Protein Length : |
539 amino acids |
| Description : |
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. |
| Conjugation : |
HIS |
| Molecular Weight : |
60.600kDa inclusive of tags |
| Form : |
Liquid |
| Purity : |
by SDS-PAGE |
| Storage buffer : |
pH: 8.00Constituents:0.32% Tris HCl, 1.17% Sodium chloride, 0.08% DTT, 0.03% EDTA, 20% Glycerol |
| Storage : |
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Sequences of amino acids : |
MGSSHHHHHHSSGLVPRGSHMPGQRRALSPKMASMRESDT GLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLS SAVKLKLLLGTLHLPRRTVDEMKGALMEIIQLASLDSDPW VLMVADILKSFPDTGSLNLELEEQNPNVQDILGELREKVG ECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKP KSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMD TTTPLKGIPKQAPFRSPTAPSVFSPTGNRTPIPPSRTLLR KERGVKLLDISELDMVGAGREAKRRRKTLDAEVVEKPAKE ETVVENATPDYAAGLVSTQKLGSLNNEPALPSTSYLPSTP SVVPASSYIPSSETPPAPSSREASRPPEEPSAPSPTLPAQ FKQRAPMYNSGLSPATPTPAAPTSPLTPTTPPAVAPTTQT PPVAMVAPQTQAPAQQQPKKNLSLTREQMFAAQEMFKTAN KVTRPEKALILGFMAGSRENPCQEQGDVIQIKLSEHTEDL PKADGQGSTTMLVDTVFEMNYATGQWTRFKKYKPMTNVS |
