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Recombinant MERS-CoV S Protein, His-tagged
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| Cat.No. : | S-017M |
| Product Overview : | Recombinant MERS-CoV Spike RBD, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Description : | MERS-CoV, which causes the Middles East Respiratory Syndrome (MERS), belongs to a family of viruses known as coronaviruses. MERS-CoV was first identified in the Kingdom of Saudi Arabia in 2012, which is a single and positive stranded RNA virus. Dromedary camels are widely considered as the source of the transmission of MERS-CoV. The rate of human transmission among household contacts of MERS patients has been approximately 5 % based on serological analysis. MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. MERS-CoV S mediates viral attachment and fusion to human cells via human cellular receptor DPP4, also known as CD26. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. Recombinant MERS-CoV Spike RBD, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Source : | Insect cells |
| Species : | MERS-CoV |
| Tag : | His |
| Form : | Liquid |
| Molecular Mass : | 28.2kDa |
| AA Sequence : | <ADP>SGVYS VSSFEAKPSG SVVEQAEGVE CDFSPLLSGT PPQVYNFKRL VFTNCNYNLT KLLSLFSVND FTCSQISPAA IASNCYSSLI LDYFSYPLSM KSDLSVSSAG PISQFNYKQS FSNPTCLILA TVPHNLTTIT KPLKYSYINK CSRLLSDDRT EVPQLVNANQ YSPCVSIVPS TVWEDGDYYR KQLSPLEGGG WLVASGSTVA MTEQLQMGFG ITVQYGTDTN SVCPKLEFAN DTKIASQLGN CVEY<HHHHH H> |
| Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
| Purity : | > 90% by SDS-PAGE |
| Applications : | SDS-PAGE |
| Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -96 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : | 0.5 mg/mL (determined by Absorbance at 280nm) |
| Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
| Official Symbol : | S |
| Synonyms : | Middle East respiratory syndrome coronavirus; Human betacoronavirus 2c EMC/2012; MERS-CoV; MERS; MERSCoV RBD; MERS RBD; receptor binding domain; RBD; Spike RBD protein |
| UniProt ID : | K0BRG7 |
| SDS-PAGE : |
3 μg by SDS-PAGE under reducing condition and visualized by coomassie blue stain |
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