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Recombinant Mouse Clu Protein, His-tagged

Cat.No. : Clu-039M
Product Overview : Purified recombinant protein of Mouse clusterin (Clu) with C-terminal His tag, expressed in HEK293 cell.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury.
Source : HEK293
Species : Mouse
Tag : His
Molecular Mass : 50.4 kDa
AA Sequence : EQEVSDNELQELSTQGSRYINKEIQ NAVQGVKHIKTLIEKTNAERKSLLN SLEEAKKKKEDALEDTRDSEMKLKA FPEVCNETMMALWEECKPCLKHTCM KFYARVCRSGSGLVGQQLEEFLNQS SPFYFWMNGDRIDSLLESDRQQSQV LDAMQDSFARASGIIDTLFQDRFFA RELHDPHYFSPIGFPHKRPHFLYPK SRLVRSLMSPSHYGPPSFHNMFQPF FEMIHQAQQAMDVQLHSPAFQFPDV DFLREGEDDRTVCKEIRRNSTGCLK MKGQCEKCQEILSVDCSTNNPAQAN LRQELNDSLQVAERLTEQYKELLQS FQSKMLNTSSLLEQLNDQFNWVSQL ANLTQGEDKYYLRVSTVTTHSSDSE VPSRVTEVVVKLFDSDPITVVLPEE VSKDNPKFMDTVAEKALQEYRRKSR AEVDHHHHHH
Endotoxin : Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Purity : >95%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Storage : Store at -80 centigrade.
Storage Buffer : Lyophilized from a 0.2 µM filtered solution of 20mM PB,150mM NaCl,pH7.4
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : Clu clusterin [ Mus musculus (house mouse) ]
Official Symbol : Clu
Synonyms : Clu; clusterin; Cli; ApoJ; Sgp2; SP-40; Sgp-2; Sugp-2; AI893575; D14Ucla3; clusterin; Apolipoprotein J; clustrin; complement lysis inhibitor; sulfated glycoprotein 2; testosterone repressed prostate message; testosterone repressed prostate message-2
Gene ID : 12759
mRNA Refseq : NM_013492
Protein Refseq : NP_038520
UniProt ID : Q06890

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CLU contribute to the regulation of inflammation, and what role does it play in immune responses and autoimmunity? 05/03/2022

CLU has anti-inflammatory properties and modulates immune responses. Its involvement in autoimmunity is linked to its ability to regulate immune cell functions and cytokine production.

How does CLU contribute to the regulation of cell survival and apoptosis, and what are the molecular mechanisms involved? 03/08/2021

CLU plays a role in regulating cell survival and apoptosis by interacting with key cellular components, including Bcl-2 family members and caspases, modulating apoptotic pathways.

How does CLU influence cell adhesion and migration, and what role does it play in tissue remodeling and repair processes? 01/16/2020

CLU modulates cell adhesion and migration, contributing to tissue remodeling and repair. Its interactions with extracellular matrix components influence cellular behaviors in wound healing and tissue homeostasis.

Can you discuss the association between CLU and neurodegenerative disorders, and how does it impact the pathogenesis of conditions like Alzheimer's disease? 11/16/2019

CLU is implicated in neurodegenerative disorders, particularly Alzheimer's disease. Its involvement in processes such as amyloid-beta aggregation and clearance influences disease progression.

Can you elaborate on the molecular interactions of CLU with lipids and its involvement in lipid transport and metabolism? 07/24/2018

CLU interacts with lipids, participating in lipid transport and metabolism. Its role in lipoprotein remodeling and cholesterol homeostasis links it to cardiovascular health.

Customer Reviews (3)

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Reviews
11/30/2021

    Impressed with the quality control. This product is a gem in our lab experiments.

    01/22/2019

      Smooth transactions and swift delivery. Our lab supplies are incomplete without this protein.

      04/17/2018

        Our lab manager introduced us to this product, and we're never going back. Essential for our studies.

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