Recombinant Mouse Clu Protein, His-tagged
Cat.No. : | Clu-039M |
Product Overview : | Purified recombinant protein of Mouse clusterin (Clu) with C-terminal His tag, expressed in HEK293 cell. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Molecular Mass : | 50.4 kDa |
AA Sequence : | EQEVSDNELQELSTQGSRYINKEIQ NAVQGVKHIKTLIEKTNAERKSLLN SLEEAKKKKEDALEDTRDSEMKLKA FPEVCNETMMALWEECKPCLKHTCM KFYARVCRSGSGLVGQQLEEFLNQS SPFYFWMNGDRIDSLLESDRQQSQV LDAMQDSFARASGIIDTLFQDRFFA RELHDPHYFSPIGFPHKRPHFLYPK SRLVRSLMSPSHYGPPSFHNMFQPF FEMIHQAQQAMDVQLHSPAFQFPDV DFLREGEDDRTVCKEIRRNSTGCLK MKGQCEKCQEILSVDCSTNNPAQAN LRQELNDSLQVAERLTEQYKELLQS FQSKMLNTSSLLEQLNDQFNWVSQL ANLTQGEDKYYLRVSTVTTHSSDSE VPSRVTEVVVKLFDSDPITVVLPEE VSKDNPKFMDTVAEKALQEYRRKSR AEVDHHHHHH |
Endotoxin : | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Purity : | >95%, as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. |
Storage Buffer : | Lyophilized from a 0.2 µM filtered solution of 20mM PB,150mM NaCl,pH7.4 |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | Clu clusterin [ Mus musculus (house mouse) ] |
Official Symbol : | Clu |
Synonyms : | Clu; clusterin; Cli; ApoJ; Sgp2; SP-40; Sgp-2; Sugp-2; AI893575; D14Ucla3; clusterin; Apolipoprotein J; clustrin; complement lysis inhibitor; sulfated glycoprotein 2; testosterone repressed prostate message; testosterone repressed prostate message-2 |
Gene ID : | 12759 |
mRNA Refseq : | NM_013492 |
Protein Refseq : | NP_038520 |
UniProt ID : | Q06890 |
Products Types
◆ Recombinant Protein | ||
CLU-621H | Recombinant Human CLU Protein, His (Fc)-Avi-tagged | +Inquiry |
CLU-746R | Recombinant Rhesus Macaque CLU Protein, His (Fc)-Avi-tagged | +Inquiry |
Clu-040M | Recombinant Mouse Clu Protein, MYC/DDK-tagged | +Inquiry |
CLU-803H | Recombinant Human CLU Protein, His&GST-tagged | +Inquiry |
CLU-3277H | Recombinant Human CLU Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
CLU-67H | Native Human Clusterin | +Inquiry |
CLU-19H | Native Human Clusterin Protein | +Inquiry |
◆ Lysates | ||
CLU-2198HCL | Recombinant Human CLU cell lysate | +Inquiry |
CLU-2195MCL | Recombinant Mouse CLU cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCLU has anti-inflammatory properties and modulates immune responses. Its involvement in autoimmunity is linked to its ability to regulate immune cell functions and cytokine production.
CLU plays a role in regulating cell survival and apoptosis by interacting with key cellular components, including Bcl-2 family members and caspases, modulating apoptotic pathways.
CLU modulates cell adhesion and migration, contributing to tissue remodeling and repair. Its interactions with extracellular matrix components influence cellular behaviors in wound healing and tissue homeostasis.
CLU is implicated in neurodegenerative disorders, particularly Alzheimer's disease. Its involvement in processes such as amyloid-beta aggregation and clearance influences disease progression.
CLU interacts with lipids, participating in lipid transport and metabolism. Its role in lipoprotein remodeling and cholesterol homeostasis links it to cardiovascular health.
Customer Reviews (3)
Write a reviewImpressed with the quality control. This product is a gem in our lab experiments.
Smooth transactions and swift delivery. Our lab supplies are incomplete without this protein.
Our lab manager introduced us to this product, and we're never going back. Essential for our studies.
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