clu
Share
  • Official Full Name
  • clusterin
  • Background
  • The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
  • Synonyms
  • CLU; clusterin; CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; apolipoprotein J; ku70-binding protein 1; sulfated glycoprotein 2; aging-associated protein 4; complement lysis inhibitor; complement cytolysis inhibitor; complement-associated protein SP-40,40; testosterone-repressed prostate message 2;
Cat.#:CLU-1526HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLU Protein, GST-tagged
+Inquiry
Cat.#:CLU-3277HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLU Protein, MYC/DDK-tagged
+Inquiry
Cat.#:CLU-106HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLU, Flag-tagged
+Inquiry
Cat.#:CLU-10HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLU, His-tagged
+Inquiry
Cat.#:CLU-11356HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLU, GST-tagged
+Inquiry
Cat.#:CLU-11HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLU Protein, His-tagged
+Inquiry
Cat.#:CLU-223HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLU, C13&N15-labeled
+Inquiry
Cat.#:CLU-26745THTag:FLAG
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLU protein, FLAG-tagged
+Inquiry
Cat.#:CLU-26748THTag:His
Source (Host):Species:Human
Product nameRecombinant Human CLU, His-tagged
+Inquiry
Cat.#:CLU-3661HTag:N/A
Source (Host):NativeSpecies:Human
Product nameHuman Clusterin
+Inquiry
Cat.#:CLU-3893HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLU, His tagged
+Inquiry
Cat.#:CLU-722HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human CLU, His-tagged
+Inquiry
Cat.#:CLU-841HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CLU Protein
+Inquiry
Cat.#:CLU-842HTag:Fc/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CLU Protein, Fc/His-tagged
+Inquiry
Cat.#:Clu-1317MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Clusterin, Flag-tagged
+Inquiry
Cat.#:Clu-1867MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Clusterin
+Inquiry
Cat.#:Clu-3302MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Clu, His tagged
+Inquiry
Cat.#:Clu-5774MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Clu protein, His-tagged
+Inquiry
Cat.#:Clu-108RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rattus Clusterin, His-tagged, T7-tagged
+Inquiry
Cat.#:CLU-1472RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CLU Protein
+Inquiry
Cat.#:Clu-2679RTag:T7/His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Clusterin, T7-His
+Inquiry
Cat.#:Clu-3664RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Clu, His-tagged
+Inquiry
Cat.#:CLU-921RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CLU Protein, His-tagged
+Inquiry
Cat.#:CLU-1318CTag:His
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine Clusterin, His-tagged
+Inquiry
Cat.#:CLU-1319CTag:Flag
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine Clusterin, Flag-tagged
+Inquiry
Cat.#:CLU-5773DTag:His/S
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog CLU protein, His & S-tagged
+Inquiry
Cat.#:CLU-5777RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit CLU protein, His-tagged
+Inquiry
Cat.#:CLU-6462CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CLU
+Inquiry
Cat.#:CLU-11058ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CLU
+Inquiry
Cat.#:CLU-5772CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CLU protein, His & T7-tagged
+Inquiry
Cat.#:CLU-5776PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CLU protein, His-tagged
+Inquiry
Cat.#:CLU-19HTag:
Source (Host):Species:Human
Product nameNative Human Clusterin Protein
+Inquiry
Cat.#:CLU-67HTag:
Source (Host):Species:Human
Product nameNative Human Clusterin
+Inquiry
Cat.#:CLU-2198HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CLU cell lysate
+Inquiry
Cat.#:CLU-2195MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CLU cell lysate
+Inquiry
Cat.#:CLU-4122HTag:
Source (Host):Human PlasmaSpecies:Human
Product nameNative Human Clusterin Protein
+Inquiry

Involved Pathway

Clu involved in several pathways and played different roles in them. We selected most pathways Clu participated on our site, such as Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Clu were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hemostasis
LRRC16A; HBBE2; OSTN; AKAP1; DGKB; KIF20A; PLEK; WDR1; VPS45; S100A10A
Platelet activation, signaling and aggregation
GNA13B; SERPINF2B; STXBP3A; F13A1B; C6orf25; MMRN1; MMRN2A; WDR1; G6b; IGF2B
Platelet degranulation
MMRN2A; TFA; IGF2B; AASS; F13A1A.1; SCG3; WDR1; SRGN; HRG; CD9B
Response to elevated platelet cytosolic Ca2+
WDR1; MMRN2A; SRGN; BRPF3; CALU; SERPINF2B; STXBP3; STXBP3A; CLU; PLEK
Validated targets of C-MYC transcriptional repression
ZFP36L1; TMEFF2; MXD4; S100A7; GFI1; DNTT; LGALS1; SFXN3; CSDE1; NDRG1

Protein Function

Clu has several biochemical functions, for example, NOT ATPase activity, chaperone binding, misfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Clu itself. We selected most functions Clu had, and list some proteins which have the same functions with Clu. You can find most of the proteins on our site.
Function
Related Protein
Function NOT ATPase activity
Related Protein RUVBL1; KIF26A; MYO18A; CLU
Function chaperone binding
Related Protein TG; CXorf41; HSPE1; GRPEL1; ATP1A1; SOD1; ST13; HSP104; DNAJB1; HES1
Function misfolded protein binding
Related Protein DNAJC3; DNAJB9; EDEM1; STUB1; HDAC6; SDF2L1; BAG6; CLU; TOR1A; HSPA5
Function protein binding
Related Protein ATP4B; KRT18; JIP1; HSCB; RTN2; RUVBL1; CD300LD; RAPGEF3; C12orf40; NCK1
Function ubiquitin protein ligase binding
Related Protein LTBR; TUBB; TRAF6; NKD2; TANK; UBE2T; DIO2; GSK3B; GPR37; BAG6

Interacting Protein

Clu has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Clu here. Most of them are supplied by our site. Hope this information will be useful for your research of Clu.
PDIA3; ADCYAP1; FOS; PPARG; Stag2; NR3C1; ZNF24; NR4A1; MDM2; BCL2L1; KLF11; POLR1C; CYP2E1

Clu Related Articles

Mourra, N; Scriva, A; et al. Clusterin expression in gastrointestinal neuroendocrine tumours is highly correlated with location and is helpful in determining the origin of liver metastases. HISTOPATHOLOGY 65:642-650(2014).
Shabayek, MI; Sayed, OM; et al. Diagnostic Evaluation of Urinary Angiogenin (ANG) and Clusterin (CLU) as Biomarker for Bladder Cancer. PATHOLOGY & ONCOLOGY RESEARCH 20:859-866(2014).