Recombinant Mouse Cntfr Protein, Myc/DDK-tagged

• Cat.No.: Cntfr-2227M
• Product Overview: Purified recombinant protein of mouse full-length ciliary neurotrophic factor receptor (Cntfr), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor that triggers the assembly of a trimolecular complex upon binding to CNTF, and initiate a downstream signaling process. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-linked cell surface protein. Mice lacking the encoded protein die shortly after birth and exhibit a reduction of motoneuron number at birth. The transgenic disruption of this gene specifically in the skeletal muscle followed by a peripheral nerve lesion impairs motor neuron axonal regeneration across the lesion site. Alternative splicing of this gene results in multiple transcript variants.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 40.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cntfr ciliary neurotrophic factor receptor [ Mus musculus (house mouse) ]
• Official Symbol: Cntfr
• Synonyms: CNTFR; ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTF receptor subunit alpha; Cntfralpha
• Gene ID: 12804
• mRNA Refseq: NM_016673
• Protein Refseq: NP_057882
• UniProt ID: O88507