CNTFR

  • Official Full Name

    ciliary neurotrophic factor receptor

  • Overview

    This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component;of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival,;differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the;transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal;transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as;well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
  • Synonyms

    CNTFR; ciliary neurotrophic factor receptor; ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTF receptor subunit alpha; MGC1774;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CNTFR-178H Recombinant Human CNTFR Mammalian Cell His
Human CNTFR-3334H Active Recombinant Human CNTFR protein, His-tagged Insect Cells His
Human CNTFR-1596H Recombinant Human Ciliary Neurotrophic Factor Receptor Sf21 Insect Cell N/A
Human CNTFR-1607H Recombinant Human CNTFR Protein, GST-tagged Wheat Germ GST
Human CNTFR-687HCL Recombinant Human CNTFR cell lysate Insect Cell N/A
Human CNTFR-361H Recombinant Human CNTFR protein, His-tagged HEK293 His
Human CNTFR-633H Recombinant Human CNTFR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CNTFR-3287H Recombinant Human CNTFR Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CNTFR-381H Recombinant Human CNTFR Protein, His-tagged E.coli His
Human CNTFR-5041H Recombinant Human CNTFR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CNTFR-184H Recombinant Human CNTFR Protein, His-tagged HEK293 His
Human CNTFR-12H Recombinant Human CNTFR Protein (23-342aa), C-His-tagged Insect Cell C-His
Human CNTFR-1986HFL Recombinant Full Length Human CNTFR Protein, C-Flag-tagged Mammalian cells Flag
Human CNTFR-1253H Active Recombinant Human CNTFR protein, His-tagged HEK293 His
Human CNTFR-1753H Recombinant Human CNTFR Protein (Thr120-Leu358), His tagged E.coli His
Human CNTFR-633H-B Recombinant Human CNTFR Protein Pre-coupled Magnetic Beads HEK293
Mouse CNTFR-3683M Recombinant Mouse Cntfr Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cntfr-2227M Recombinant Mouse Cntfr Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CNTFR-1501R Recombinant Rat CNTFR Protein Mammalian Cell His
Rat Cntfr-4084R Recombinant Rat Cntfr, His tagged Insect Cell His
Rat CNTFR-598RCL Recombinant Rat CNTFR cell lysate Insect Cell N/A
Rat CNTFR-1158R-B Recombinant Rat CNTFR Protein Pre-coupled Magnetic Beads HEK293
Rat CNTFR-1158R Recombinant Rat CNTFR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CNTFR-949R Recombinant Rhesus monkey CNTFR Protein, His-tagged Mammalian Cell His
Rhesus Macaque CNTFR-774R-B Recombinant Rhesus Macaque CNTFR Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CNTFR-774R Recombinant Rhesus Macaque CNTFR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CNTFR-5666Z Recombinant Zebrafish CNTFR Mammalian Cell His
Chicken CNTFR-6585C Recombinant Chicken CNTFR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CNTFR Related Articles
  • CNTFR Related Gene Family
  • CNTFR Related Research Area

CNTFR involved in several pathways and played different roles in them. We selected most pathways CNTFR participated on our site, such as Adipogenesis, Cytokine-cytokine receptor interaction, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNTFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisCEBPD;NR2F1A;NAMPT;CEBPB;SPOCK1;SMAD3B;BMP1;MEF2AA;KLF7
Cytokine-cytokine receptor interactionIFNA21;TNFSF10;Cxcl15;TSLP;IL12RB1;INHBA;EGFRA;IFNGR2;TNFB
Delta-Notch Signaling PathwayWDR12;YY1;JAG2;CNTFR;MAGEA1;CNTN1;HES6;HIVEP3;TCF3B
Jak-STAT signaling pathwayIL2RG;RAF1;OSMR;IL4R;TP-1;PRLRA;CCND2A;IL13RA1;GH1

CNTFR has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor activity, cytokine binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNTFR itself. We selected most functions CNTFR had, and list some proteins which have the same functions with CNTFR. You can find most of the proteins on our site.

Function Related Protein
contributes_to ciliary neurotrophic factor receptor activityLIFR;Il6ra;IL6R;CNTFR
cytokine bindingNOG;KITB;Fzd4;IFNGR1;CD74;NRP2;CHRD;CRLF1;KIT
receptor bindingNXPH1;PEX14;F7;CD160;PTK2AA;HSPA1A;APP;ABL1;SLC9A3R1

CNTFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNTFR here. Most of them are supplied by our site. Hope this information will be useful for your research of CNTFR.

ABL1; FYN; NCK1; CRK; GRB2; PLSCR1; APPBP2; CRAMP1L; KRTAP4-12

Lee, N; Spearry, RP; et al. Muscle ciliary neurotrophic factor receptor promotes axonal regeneration and functional recovery following peripheral nerve lesion. JOURNAL OF COMPARATIVE NEUROLOGY 521:2947-2965(2013).
Lu, J; Ksendzovsky, A; et al. CNTF receptor subunit alpha as a marker for glioma tumor-initiating cells and tumor grade. JOURNAL OF NEUROSURGERY 117:1022-1031(2012).
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