| Description : |
Predicted to enable several functions, including ErbB-3 class receptor binding activity; Hsp90 protein binding activity; and enzyme binding activity. Predicted to contribute to growth factor binding activity. Involved in positive regulation of GTPase activity and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). |
| Source : |
HEK293 |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
70.5 kDa |
| Protein Length : |
711 |
| AA Sequence : |
MELAAWCRWGFLLALLSPGAAGTQV CTGTDMKLRLPASPETHLDMLRHLY QGCQVVQGNLELTYLPANASLSFLQ DIQEVQGYMLIAHNRVKHVPLQRLR IVRGTQLFEDKYALAVLDNRDPLDN VTTAAPGRTPEGLRELQLRSLTEIL KGGVLIRGNPQLCYQDMVLWKDVLR KNNQLAPVDMDTNRSRACPPCAPTC KDNHCWGESPEDCQILTGTICTSGC ARCKGRLPTDCCHEQCAAGCTGPKH SDCLACLHFNHSGICELHCPALITY NTDTFESMLNPEGRYTFGASCVTTC PYNYLSTEVGSCTLVCPPNNQEVTA EDGTQRCEKCSKPCAGVCYGLGMEH LRGARAITSDNIQEFAGCKKIFGSL AFLPESFDGNPSSGVAPLKPEHLQV FETLEEITGYLYISAWPESFQDLSV FQNLRVIRGRILHDGAYSLTLQGLG IHSLGLRSLRELGSGLALIHRNTHL CFVNTVPWDQLFRNPHQALLHSGNR PEEACGLEGLVCNSLCARGHCWGPG PTQCVNCSQFLRGQECVEECRVWKG LPREYVRGKHCLPCHPECQPQNSSE TCYGSEADQCEACAHYKDSSSCVAR CPSGVKPDLSYMPIWKYPDEEGICQ PCPINCTHSCVDLDERGCPAEQRAS PVTFIIATVVGVLLFLIIVVVIGIL IKRRRQKIRKYTMRRLLQETEVRRA EGLLAPPWLCS |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
