erbb2

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erbb2

Official Full Name v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Background This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Synonyms ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;
    • Species :
    • Canine
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Rabbit
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • DDDDK
    • DDK
    • His
    • Fc
    • GST
    • Avi
    • T7
    • His-Avi
    • HlgG1 Fc
    • human
    • IgG1
    • mouse IgG2a Fc
    • MYC/DDK
    • Myc
    • N/A
    • Strep
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ERBB2-033HA Recombinant Human ERBB2 protein, Fc-tagged, APC labeled HEK293 Fc
    Human ERBB2-033HP Recombinant Human ERBB2 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human ERBB2-046H Recombinant Human ERBB2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human ERBB2-077H Recombinant Human ERBB2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human ERBB2-083H Recombinant Human ERBB2 protein, His-Avi-tagged HEK293 His-Avi
    Human ERBB2-1110H Recombinant Human ERBB2 Protein (Met1-Thr652), HlgG1 Fc-tagged, Biotinylated HEK293 HlgG1 Fc
    Human ERBB2-111HG GMP Recombinant Human ERBB2 protein, His-tagged HEK293 His
    Cynomolgus ERBB2-1216CA Recombinant Cynomolgus ERBB2 protein, Fc-tagged, APC labeled HEK293 Fc
    Cynomolgus ERBB2-1216CP Recombinant Cynomolgus ERBB2 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human ERBB2-177HB Recombinant Human ERBB2 protein, DDDDK-tagged, Biotinylated HEK293 DDDDK
    Human ERBB2-183H Recombinant Human ERBB2 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Mouse Erbb2-2514MA Recombinant Mouse Erbb2 protein, Fc-tagged, APC labeled HEK293 Fc
    Mouse Erbb2-2514MP Recombinant Mouse Erbb2 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human ERBB2-359H Recombinant Human ERBB2 Protein, Strep-tagged HEK293 Strep
    Human ERBB2-360H Recombinant Human ERBB2 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Rat Erbb2-4097RA Recombinant Rat Erbb2 protein, Fc-tagged, APC labeled HEK293 Fc
    Rat Erbb2-4097RP Recombinant Rat Erbb2 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human ERBB2-40HA Recombinant Human ERBB2 protein, Fc-tagged, APC labeled HEK293 Fc
    Human ERBB2-40HP Recombinant Human ERBB2 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human ERBB2-41HA Recombinant Human ERBB2 protein, Fc-tagged, APC labeled HEK293 Fc
    Human ERBB2-41HP Recombinant Human ERBB2 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human ERBB2-552HA Recombinant Human ERBB2 protein, Fc-tagged, APC labeled NS0 Fc
    Human ERBB2-552HP Recombinant Human ERBB2 protein, Fc-tagged, R-PE labeled NS0 Fc
    Human ERBB2-57H Recombinant Human ERBB2 protein, Fc-tagged HEK293 mouse IgG2a Fc
    Human ERBB2-626H Recombinant Human ERBB2 protein(S310F), His-tagged HEK293 His
    Human ERBB2-627H Recombinant Human ERBB2 protein(S310Y), His-tagged HEK293 His
    Human ERBB2-823H Recombinant Human ERBB2 protein(Domain IV), His-Avi-tagged HEK293 His-Avi
    Human ERBB2-824H Recombinant Human ERBB2 protein (Met1-Cys195), His-tagged HEK293 His
    Mouse Erbb2-969M Recombinant Mouse Erbb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HER2-006M ERBB2 protein-coupled magnetic beads
    Human CAB11534RH Rabbit Anti-Human ErbB2 / HER2 Monoclonal Antibody, FITC-Conjugated Rabbit N/A
    Human ERBB2-033H Recombinant Human ERBB2 Protein, Fc-tagged HEK293 Fc
    Human ERBB2-034H Recombinant Human ERBB2 Protein, His-tagged HEK293 His
    Human ERBB2-1215H Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog (avian), His-tagged Insect Cell His
    Human ERBB2-176H Recombinant Human ERBB2 Protein, His & GST-tagged Insect Cell His/GST
    Human ERBB2-177H Recombinant Human ERBB2 protein HEK293
    Human ERBB2-182H Recombinant Human ERBB2, His-tagged, Biotinylated HEK293 His
    Human ERBB2-1893H Recombinant Human ERBB2 protein, His & GST-tagged E.coli His/GST
    Human ERBB2-1894H Recombinant Human ERBB2 protein, His & T7-tagged E.coli His/T7
    Human ERBB2-18H Recombinant Human c-ERBB2 E.coli N/A
    Human ERBB2-200H Recombinant Human ERBB2, His-tagged, C13&N15 Labeled HEK293 His
    Human ERBB2-203H Recombinant Human ERBB2 protein, DDK/His-tagged HEK293 DDK/His
    Human ERBB2-204H Recombinant Human ERBB2 protein, DDK-tagged Insect Cell DDK
    Human ERBB2-205H Recombinant Human ERBB2 protein, DDK-tagged Insect Cell DDK
    Human ERBB2-206H Recombinant Human ERBB2 protein, DDK-tagged Insect Cell DDK
    Human ERBB2-207H Recombinant Human ERBB2 protein, DDK-tagged CHO DDK
    Human ERBB2-2118H Recombinant Human ERBB2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ERBB2-211H Recombinant Human ERBB2, His-tagged HEK293 His
    Human ERBB2-229H Recombinant Human ERBB2, StrepII-tagged Human Cell Strep II
    Human ERBB2-236H Recombinant Human ERBB2, C13&N15-labeled HEK293 N/A
    Human ERBB2-2515H Recombinant Human ERBB2 N/A
    Human ERBB2-2658HCL Recombinant Human ERBB2 cell lysate Human Cell N/A
    Human ERBB2-26845TH Recombinant Human ERBB2 E.coli N/A
    Human ERBB2-26846TH Recombinant Human ERBB2 N/A
    Human ERBB2-28688TH Recombinant Human ERBB2, GST-tagged E.coli GST
    Human ERBB2-328H Recombinant Human ERBB2, GST-tagged, Active Sf9 Insect Cell GST
    Human ERBB2-3441H Recombinant Human ERBB2 Protein Insect Cell N/A
    Human ERBB2-3442H Recombinant Human ERBB2 Protein, GST-tagged Insect Cell GST
    Human ERBB2-3444H Recombinant Human ERBB2 Protein, GST-tagged Wheat Germ GST
    Human ERBB2-3681H Recombinant Human, ERBB2 E.coli N/A
    Human ERBB2-40H Recombinant Human ERBB2 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human ERBB2-41H Recombinant Human ERBB2, Fc tagged Human Cell Fc
    Human ERBB2-42H Recombinant Human HER2 Mutant (d755-759), GST-tagged Sf9 Insect Cell GST
    Human ERBB2-43H Recombinant Human HER2 Mutant (G776VC), GST-tagged Sf9 Insect Cell GST
    Human ERBB2-465HCL Recombinant Human ERBB2 cell lysate Insect Cell N/A
    Human ERBB2-552H Recombinant Human ERBB2 Protein, Fc Chimera NS0 Fc
    Human ERBB2-60H Recombinant Human HER2 (A775_G776insYVMA), GST-tagged Sf9 Insect Cell GST
    Human ERBB2-61H Recombinant Human HER2 (V777_G778insCG), GST-tagged Sf9 Insect Cell GST
    Human ERBB2-81H Recombinant Human erbB-2, Fc-his-tag NS0 Fc/His
    Human ERBB2-894H Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog (avian), Methionine Human N/A
    Human ERBB2-922H Recombinant Human ERBB2, His tagged Human Cell His
    Mouse Erbb2-1152M Recombinant Mouse Erbb2 protein, His-tagged HEK293 His
    Mouse ERBB2-1727MCL Recombinant Mouse ERBB2 cell lysate Human Cell N/A
    Mouse Erbb2-1895M Recombinant Mouse Erbb2 protein, His & T7-tagged E.coli His/T7
    Mouse Erbb2-2514M Recombinant Mouse Erbb2, Fc tagged Human Cell Fc
    Rat Erbb2-1896R Recombinant Rat Erbb2 protein, His & GST-tagged E.coli His/GST
    Rat ERBB2-2010RCL Recombinant Rat ERBB2 cell lysate Human Cell N/A
    Rat Erbb2-2120R Recombinant Rat Erbb2 Protein, His-tagged E.coli His
    Rat Erbb2-4097R Recombinant Rat Erbb2, Fc tagged Human Cell Fc
    Rat Erbb2-4098R Recombinant Rat Erbb2, His tagged Human Cell His
    Rat Erbb2-4099R Recombinant Rat Erbb2, None tagged Human Cell N/A
    Cynomolgus Monkey ERBB2-001CCL Recombinant Cynomolgus ERBB2 cell lysate Human Cell N/A
    Cynomolgus Monkey ERBB2-1216C Recombinant Cynomolgus ERBB2 Protein, Fc-tagged HEK293 Fc
    Cynomolgus ERBB2-1217C Recombinant Cynomolgus ERBB2 protein, His-tagged HEK293 His
    Cynomolgus Monkey ERBB2-206C Recombinant Cynomolgus ERBB2, His-tagged Human Cell His
    Rhesus Macaque ERBB2-2008RCL Recombinant Rhesus ERBB2 cell lysate Human Cell N/A
    Rhesus Macaque ERBB2-4112R Recombinant Rhesus ERBB2, Fc tagged Human Cell Fc
    Rhesus Macaque ERBB2-4113R Recombinant Rhesus ERBB2, His tagged Human Cell His
    Canine ERBB2-171C Recombinant Canine ERBB2, His-tagged Human Cell His
    Chicken ERBB2-3453C Recombinant Chicken ERBB2 Mammalian Cell His
    Zebrafish ERBB2-10470Z Recombinant Zebrafish ERBB2 Mammalian Cell His
    ERBB2-01 Recombinant HER2/neu (478-584) E.coli N/A

    erbb2 involved in several pathways and played different roles in them. We selected most pathways erbb2 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with erbb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway PIK3CA; MAP2K1; TGFA; AKT3A; CBL; SHC2; RPS6KB1; SHC1; ERBB4A; RAF1B
    Calcium signaling pathway PRKCB; CAMK2D; PPP3R2; PRKCBA; ATP2A2; AGTR1B; TBXA2R; PDGFRA; PRKACA; GNA15.1
    HIF- signaling pathway ARNT; MKNK2; Trf; PIK3R5; HKDC1; MAPK1; CAMK2B; PLCG2; ENO1; ANGPT1
    Focal adhesion SEPP1; RAF1B; PPP1R12C; RAF1A; LAMA5; ITGB4; PTENA; PARVAA; LAMB1; PAK1
    Adherens junction FYNA; ACTN3B; ACTN4; PVRL1B; PTPRM; BAIAP2; ACTB2; PTPRFB; INSRB; PTPRJA
    Pathways in cancer PTEN; SMAD2; PTGER4; FGF9; TGFB1; MMP9; FGFR1; ARHGEF12; PIK3CB; TRAF2
    Proteoglycans in cancer CTTN; FZD5; WNT5B; PTK2; FZD7; PRKACB; RAF1; RHOA; WNT7B; FASLG
    MicroRNAs in cancer Pdgfa&Pdgfb; ZFPM2; Abcb1b; EZR; NFKB1; CCND2; RHOA; SLC7A1; TNR; PRKCE
    Pancreatic cancer MAP2K1; TGFB2; MAPK8; AKT2; PIK3R3; ARHGEF6; RAC3; RALB; NFKB1; PIK3CB
    Endometrial cancer APC; KRAS; MAP2K2; RAF1; PDPK1; AKT2; TCF7L2; PIK3R3; AXIN1; GSK3B
    Prostate cancer BRAF; BAD; CCNE2; KRAS; NDRG1; PDGFRB; PDGFRA; TRP53; CREB3L1; CCND1
    Bladder cancer CDK4; TYMP; MMP9; ARAF; BRAF; MAP2K2; MAPK3; RB1; MAP2K1; E2F2
    Non-small cell lung cancer TP53; ALK; RAF1; PIK3CA; PRKCB; MAP2K2; PIK3R5; PIK3R2; AKT1; MAP2K1
    Central carbon metabolism in cancer SLC2A2; NTRK3; LDHA; PFKM; G6PD; FGFR3; PDHB; HKDC1; PKM2; PTEN

    erbb2 has several biochemical functions, for example, ATP binding, ErbB-3 class receptor binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by erbb2 itself. We selected most functions erbb2 had, and list some proteins which have the same functions with erbb2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CHD4A; MYO1C; DDX43; NUAK2; MCM8; MAT2AA; NMNAT1; EIF2AK2; PLK5; UBE2D3
    ErbB-3 class receptor binding CDK5; ERBB2; PIK3R1; NRG1
    Hsp90 protein binding HIF1A; NPAS2; EIF2AK3; NASP; UNC45B; PPID; RPS3; AHR; PACRG; USP19
    RNA polymerase I core binding ERBB2
    glycoprotein binding ITGAM; STX1A; LMAN2; VIM; ACE2; ITGB2; DNAJC5; BMPR1B; Serpina1b; LCK
    contributes_to growth factor binding ERBB2; IL6ST; TGFBR1; ACVR1B
    identical protein binding DACT3; CALHM1; VEGFA; PFKFB1; GPSM2; SRI; CEP170L; RALYL; IGF2R; ATXN10
    protein C-terminus binding VGLL1; NCL; TJP2; FIGN; PPM1A; CEP120; COIL; YWHAQ; BLOC1S2; VAMP2
    protein binding PRKAA2; GPR77; ATP6V1C2; SNX31; LRCH3; CCNY; MRPL1; GHRHR; RNF213; KLF15
    protein dimerization activity HER6; FBXW11B; WWOX; LDB1A; TWIST1A; ATM; GPR139; HIF1AB; AIFM1; PPP3CB
    protein heterodimerization activity HIST1H2BA; CEBPB; HIST1H4L; TOP2B; AOC3; BTBD11; PAFAH1B2; PPP3CB; VOX; HER11
    protein phosphatase binding LCK; KAT2A; PPP1R3C; DLG3; SNX3; HSP90B1; PPP6R3; TRAF2; JUP; PPP6R1
    protein tyrosine kinase activity FGFR1; FGFR1B; INSR; KDRL; EPHA4B; CLK2; LYN; KITA; TTN; FGFR2
    receptor signaling protein tyrosine kinase activity ERBB3B; KITA; LYN; KIT; KITB; ERBB2; ERBB4; EGFRA; INSR; SYK
    transmembrane receptor protein tyrosine kinase activity EPHA4B; ERBB3A; TEK; CSF1RA; RET; ERBB2; EK1; KDRL; RYK; NPTN
    transmembrane signaling receptor activity FZD8A; KLRC2; ADCYAP1R1A; GPR98; CD4; ANTXR1; SELE; KLRC1; KLRB1; TNFRSF10C
    ubiquitin protein ligase binding UBE2O; USP25; KCNQ3; BAG5; TUBB; PDE4D; STUB1; RNF20; UBE2U; GPI1

    erbb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with erbb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of erbb2.

    ERBB3

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