ERBB2

  • Official Full Name

    v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

  • Overview

    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • GMP Proteins
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Dog
  • Human
  • Human
  • Monkey
  • Mouse
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Rabbit
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • Fc
  • His
  • Myc
  • DDK
  • DDDDK
  • DDK|His
  • DYKDDDDK
  • Avi
  • Fc|His
  • Flag
  • GST
  • hFc
  • His (Fc)
  • His(C
  • ter)
  • His|Avi
  • His|GST
  • His|T7
  • HlgG1 Fc
  • human|IgG1|Fc
  • LEVLFQ
  • mouse IgG2a Fc
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Strep
  • Strep II
  • Tag Free
  • Twin
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ERBB2-42H Active Recombinant Human HER2 Mutant (d755-759), GST-tagged Sf9 Insect Cell GST
Human ERBB2-552H Active Recombinant Human ERBB2 Protein, Fc Chimera Mammalian cells Fc
Human ERBB2-182H Active Recombinant Human ERBB2, His-tagged, Biotinylated HEK293 His
Human ERBB2-033H Active Recombinant Human ERBB2 Protein, Fc-tagged HEK293 Fc
Human ERBB2-034H Active Recombinant Human ERBB2 protein, His-tagged HEK293 His Thr23-Thr652
Human ERBB2-43H Active Recombinant Human HER2 Mutant (G776VC), GST-tagged Sf9 Insect Cell GST
Human ERBB2-177H Active Recombinant Human ERBB2 Protein, DDDDK-tagged HEK293 DDDDK
Human ERBB2-033HAF555 Active Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human ERBB2-033HAF488 Active Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human ERBB2-051H Active Recombinant Human ERBB2 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Ser22-Thr652
Human ERBB2-570H Active Recombinant Human ERBB2 Protein, His-tagged, Biotinylated HEK293 His Pro489-Cys630
Human ERBB2-552HAF555 Active Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
Human ERBB2-039H Active Recombinant Human ERBB2 Protein, DDDDK-tagged HEK293 DDDDK Met1-Thr652
Human ERBB2-177HB Active Recombinant Human ERBB2 protein, DDDDK-tagged, Biotinylated HEK293 DDDDK
Human ERBB2-14H Active Recombinant Human ERBB2 Protein, Fc/His-tagged, Alexa Fluor® 647 conjugated NS0 Fc/His
Human ERBB2-552HAF647 Active Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
Human ERBB2-177HAF488 Active Recombinant Human ERBB2 Protein, DDDDK-tagged, Alexa Fluor 488 conjugated HEK293 DDDDK
Human ERBB2-13H Active Recombinant Human ERBB2 Protein, Fc/His-tagged, Alexa Fluor® 488 conjugated NS0 Fc/His
Human ERBB2-552HAF488 Active Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
Human ERBB2-033HAF647 Active Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human ERBB2-177HAF647 Active Recombinant Human ERBB2 Protein, DDDDK-tagged, Alexa Fluor 647 conjugated HEK293 DDDDK
Human ERBB2-177HAF555 Active Recombinant Human ERBB2 Protein, DDDDK-tagged, Alexa Fluor 555 conjugated HEK293 DDDDK
Human ERBB2-552HF Active Recombinant Human ERBB2 Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
Human ERBB2-1062H Recombinant Human ERBB2 protein(Met1-Thr652), Biotinylated HEK293 N/A Met1-Thr652
Human ERBB2-177HF Active Recombinant Human ERBB2 Protein, DDDDK-tagged, FITC conjugated HEK293 DDDDK
Human ERBB2-922H Recombinant Human ERBB2, His tagged Human Cell His
Human ERBB2-204H Recombinant Human ERBB2 protein, DDK-tagged Insect Cell DDK Lys676-Val1255
Human ERBB2-205H Recombinant Human ERBB2 protein, DDK-tagged Insect Cell DDK
Human ERBB2-894H Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog (avian), Methionine Human N/A
Human ERBB2-211H Recombinant Human ERBB2, His-tagged HEK293 His
Human ERBB2-206H Recombinant Human ERBB2 protein, DDK-tagged Insect Cell DDK Thr23-Thr652
Human ERBB2-207H Recombinant Human ERBB2 protein, DDK-tagged CHO DDK
Human ERBB2-2515H Recombinant Human ERBB2 N/A
Human ERBB2-60H Recombinant Human HER2 (A775_G776insYVMA), GST-tagged Sf9 Insect Cell GST
Human ERBB2-26845TH Recombinant Human ERBB2 E.coli N/A
Human ERBB2-200H Recombinant Human ERBB2, His-tagged, C13&N15 Labeled HEK293 His
Human ERBB2-26846TH Recombinant Human ERBB2 N/A
Human ERBB2-61H Recombinant Human HER2 (V777_G778insCG), GST-tagged Sf9 Insect Cell GST
Human ERBB2-41H Recombinant Human ERBB2, Fc tagged Human Cell Fc
Human ERBB2-18H Recombinant Human c-ERBB2 E.coli N/A
Human ERBB2-3441H Active Recombinant Human ERBB2 Protein Insect Cell N/A
Human ERBB2-176H Recombinant Human ERBB2 Protein, His & GST-tagged Insect Cell His/GST
Human ERBB2-229H Recombinant Human ERBB2, StrepII-tagged Human Cell Strep II 23-652, 630 a.a.
Human ERBB2-236H Recombinant Human ERBB2, C13&N15-labeled HEK293 N/A
Human ERBB2-3442H Active Recombinant Human ERBB2 Protein, GST-tagged Insect Cell GST
Human ERBB2-28688TH Recombinant Human ERBB2, GST-tagged E.coli GST
Human ERBB2-1215H Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog (avian), His-tagged Insect Cell His
Human ERBB2-81H Recombinant Human erbB-2, Fc-his-tag Mammalian cells Fc/His
Human ERBB2-3444H Recombinant Human ERBB2 Protein, GST-tagged Wheat Germ GST
Human ERBB2-328H Recombinant Human ERBB2, GST-tagged, Active Sf9 Insect Cell GST
Human ERBB2-3681H Recombinant Human, ERBB2 E.coli N/A
Human ERBB2-203H Recombinant Human ERBB2 protein, DDK/His-tagged HEK293 DDK/His Thr23-Thr652
Human ERBB2-40H Recombinant Human ERBB2 protein, Fc-tagged HEK293 human/IgG1/Fc 428
Human ERBB2-1893H Recombinant Human ERBB2 protein, His & GST-tagged E.coli His/GST Phe376~Gly578 (Accession # P04626)
Human ERBB2-1894H Recombinant Human ERBB2 protein, His & T7-tagged E.coli His/T7 Thr23~Gly372 (Accession # P04626)
Human ERBB2-465HCL Recombinant Human ERBB2 cell lysate Insect Cell N/A
Human ERBB2-2658HCL Recombinant Human ERBB2 cell lysate Human Cell N/A
Human CAB11534RH Rabbit Anti-Human ErbB2 / HER2 Monoclonal Antibody, FITC-Conjugated Rabbit N/A
Human ERBB2-2118H Recombinant Human ERBB2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ERBB2-2546H Recombinant Human ERBB2 protein(1101-1180 aa), C-His-tagged E.coli C-His 1101-1180 aa
Human ERBB2-183H Active Recombinant Human ERBB2 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ERBB2-033HA Recombinant Human ERBB2 protein, Fc-tagged, APC labeled HEK293 Fc
Human ERBB2-40HP Recombinant Human ERBB2 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human ERBB2-627H Recombinant Human ERBB2 protein(S310Y), His-tagged HEK293 His Thr 23 - Thr 652
Human ERBB2-033HP Recombinant Human ERBB2 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human ERBB2-40HA Recombinant Human ERBB2 protein, Fc-tagged, APC labeled HEK293 Fc
Human ERBB2-41HP Recombinant Human ERBB2 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human ERBB2-111HG Active GMP Recombinant Human ERBB2 protein HEK293 DNA sequence encoding Human HER2(UniProtKB - P04626) was expressed with His tag at the C-terminal.
Human ERBB2-552HP Recombinant Human ERBB2 protein, Fc-tagged, R-PE labeled Mammalian cells Fc
Human ERBB2-154H Recombinant Human ERBB2 Protein, His-tagged Human Cells His
Human ERBB2-57H Recombinant Human ERBB2 protein, Fc-tagged HEK293 mouse IgG2a Fc Thr23-Thr652
Human ERBB2-359H Active Recombinant Human ERBB2 Protein, Strep-tagged HEK293 Strep Thr 23 - Thr 652
Human ERBB2-41HA Recombinant Human ERBB2 protein, Fc-tagged, APC labeled HEK293 Fc
Human ERBB2-920H Recombinant Human ERBB2 Protein, Flag-tagged HEK293 Flag Met1-Thr652
Human ERBB2-626H Active Recombinant Human ERBB2 protein(S310F), His-tagged HEK293 His Thr 23 - Thr 652
Human ERBB2-360H Active Recombinant Human ERBB2 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Thr 23 - Thr 652
Human ERBB2-552HA Recombinant Human ERBB2 protein, Fc-tagged, APC labeled Mammalian cells Fc
Human ERBB2-176HAF555 Recombinant Human ERBB2 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cell His/GST 817
Human HER2-006M ERBB2 protein-coupled Magnetic Beads HEK293 Thr 23 - Thr 652
Human ERBB2-1110H Recombinant Human ERBB2 Protein (Met1-Thr652), HlgG1 Fc-tagged, Biotinylated HEK293 HlgG1 Fc Met1-Thr652
Human ERBB2-046H Recombinant Human ERBB2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human ERBB2-41HAF555 Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 868
Human ERBB2-823H Recombinant Human ERBB2 protein(Domain IV), His-Avi-tagged HEK293 His-Avi It contains Pro489-Cys630 (Domain IV).
Human ERBB2-233HB Recombinant Human ERBB2 protein, DDDDK-tagged, Biotinylated HEK293 DDDDK Met1-Thr652
Human ERBB2-077H Recombinant Human ERBB2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human ERBB2-193H Recombinant Human ERBB2 protein, His-tagged HEK293 His Asn 498 - Ala 648
Human ERBB2-40HAF555 Recombinant Human ERBB2 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc 428
Human ERBB2-119H Active Recombinant Human ERBB2 protein, His-tagged HEK293 His Thr23-Ala510
Human ERBB2-083H Recombinant Human ERBB2 protein, His-Avi-tagged HEK293 His-Avi It contains Thr 23 - Thr 652.
Human ERBB2-038HP Recombinant Human ERBB2 protein, His-tagged, PE-Labeled HEK293 His Thr23-Thr652
Human ERBB2-41HAF488 Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 868
Human ERBB2-40HF Recombinant Human ERBB2 Protein, hFc-tagged, FITC conjugated HEK293 hFc 428
Human ERBB2-569H Recombinant Human ERBB2 protein, His-tagged, Biotinylated HEK293 His Met1-Cys195
Human ERBB2-2865H Recombinant Human ERBB2 protein, His-tagged E.coli His 23-652aa
Human ERBB2-922HAF488 Recombinant Human ERBB2 protein, His-tagged, Alexa Fluor 488-Labeled HEK293 His Thr23-Thr652
Human ERBB2-1537H Active Recombinant Human ERBB2 protein, Twin-Strep-tagged HEK293 Twin-Strep Thr23-Thr652
Human ERBB2-434HF Active Recombinant Human ERBB2 protein, Fc-tagged,FITC-Labeled HEK293 Fc Thr23-Thr652
Human ERBB2-287H Recombinant Human ERBB2 Protein HEK293 1255
Human ERBB2-176HAF488 Recombinant Human ERBB2 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cell His/GST 817
Human ERBB2-2613H Recombinant Human ERBB2 Protein (Thr23-Thr652), C-Fc tagged Mammalian cells C-Fc Thr23-Thr652
Human ERBB2-2866H Recombinant Human ERBB2 protein, His-tagged E.coli His 153-598aa
Human ERBB2-4087H Recombinant Human ERBB2 Protein (Met1-Thr652), C-His tagged Mammalian cells C-His Met1-Thr652
Human ERBB2-824H Recombinant Human ERBB2 protein (Met1-Cys195), His-tagged HEK293 His
Human ERBB2-40HAF647 Recombinant Human ERBB2 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc 428
Human ERBB2-2867H Recombinant Human ERBB2 protein, His&Myc-tagged E.coli His&Myc 720-976aa
Human ERBB2-153H Recombinant Human ERBB2 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human ERBB2-40HAF488 Recombinant Human ERBB2 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc 428
Human ERBB2-921H Recombinant Human ERBB2 Protein, Flag-tagged, Biotinylated HEK293 Flag Met1-Thr652
Human ERBB2-922HAF555 Recombinant Human ERBB2 protein, His-tagged, Alexa Fluor 555-Labeled HEK293 His Thr23-Thr652
Human ERBB2-2136H Active Recombinant Human ERBB2 protein HEK293 N/A Thr23-Thr652
Human ERBB2-922HAF647 Recombinant Human ERBB2 protein, His-tagged, Alexa Fluor 647-Labeled HEK293 His Thr23-Thr652
Human ERBB2-033HF Active Recombinant Human ERBB2 protein, His-tagged, FITC-Labeled HEK293 His Thr23-Thr652
Human ERBB2-922HF Recombinant Human ERBB2 Protein, His-tagged, FITC conjugated HEK293 His 641
Human ERBB2-176HAF647 Recombinant Human ERBB2 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cell His/GST 817
Human ERBB2-4385HF Recombinant Full Length Human ERBB2 Protein, GST-tagged In Vitro Cell Free System GST 1255 amino acids
Human ERBB2-41HAF647 Recombinant Human ERBB2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 868
Human ERBB2-519HFL Recombinant Full Length Human ERBB2 Protein, C-DDK-tagged Mammalian cells DDK
Human ERBB2-41HF Recombinant Human ERBB2 Protein, Fc-tagged, FITC conjugated HEK293 Fc 868
Human ERBB2-6H Recombinant Human ERBB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ERBB2-67H Recombinant Human ERBB2 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Thr23-Thr652
Human ERBB2-76H Active Recombinant Human ERBB2(676-end) Protein, C-His-tagged Sf21 His 676-end
Human ERBB2-05HFL Active Recombinant Full Length Human ERBB2 Protein, C-Flag-tagged Mammalian cells Flag
Human ERBB2-282H Recombinant Human ERBB2 Protein, His-tagged, Biotinylated HEK293 His 1255
Human ERBB2-0006H Recombinant Human ERBB2 Protein HEK293 cells
Human ERBB2-283H Recombinant Human ERBB2 Protein, Fc-tagged HEK293 Fc 1255
Human ERBB2-286H Recombinant Human ERBB2 Protein, Strep-tagged HEK293 Strep 1255
Human ERBB2-284H Recombinant Human ERBB2 Protein, His-tagged HEK293 His 1255
Human ErbB2-556H Recombinant Human ErbB2 Protein, C13 and N15 Labeled HEK293 1255
Human ERBB2-285H Recombinant Human ERBB2 Protein, Fc-tagged HEK293 Fc 1255
Human ERBB2-6H-B Recombinant Human ERBB2 Protein Pre-coupled Magnetic Beads HEK293
Human ERBB2-0275H Active Recombinant Human ERBB2 protein, His&Avi-tagged, Biotinylated HEK293 His&Avi Met1-Thr652
Human ERBB2-1535H Recombinant Human ERBB2 protein, His-tagged, APC-Labeled HEK293 His Thr23-Thr652
Human ERBB2-2612H Recombinant Human ERBB2 Protein (Thr23-Thr652), C-His tagged Mammalian cells C-His Thr23-Thr652
Human ERBB2-1336H Recombinant Human ERBB2 Protein (Thr23-Gly372), N-His tagged E.coli N-His Thr23-Gly372
Human ErbB2-2150H Active Recombinant Human ErbB2 protein, hFc-tagged, Biotinylated HEK293 hFc Met1-Thr652
Human ERBB2-4683H Active Recombinant Human ERBB2 Protein, His-tagged, PE-Labeled HEK293 His Thr 23 - Thr 652
Human ERBB2-111H Recombinant Human ERBB2 Protein, ECD, Tag Free, Biotinylated CHO Tag Free ECD
Human ERBB2-742M ERBB2 Antibody-coupled magnetic MicroBeads
Human ERBB2-8987M Active ERBB2 protein-coupled magnetic Beads HEK293 Thr 23 - Thr 652
Human ERBB2-176HF Recombinant Human ERBB2 Protein, His/GST-tagged, FITC conjugated Insect Cell His/GST 817
Mouse Erbb2-1152M Active Recombinant Mouse Erbb2 protein, His-tagged HEK293 His Met 1-Thr 653
Mouse Erbb2-1895M Recombinant Mouse Erbb2 protein, His & T7-tagged E.coli His/T7 Phe377~Gly579 (Accession # P70424)
Mouse Erbb2-2514M Active Recombinant Mouse Erbb2 protein, hFc-tagged HEK293 hFc Met1-Thr653
Mouse ERBB2-1727MCL Recombinant Mouse ERBB2 cell lysate Human Cell N/A
Mouse Erbb2-2514MAF647 Recombinant Mouse Erbb2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 872
Mouse Erbb2-2514MF Recombinant Mouse Erbb2 Protein, Fc-tagged, FITC conjugated HEK293 Fc 872
Mouse Erbb2-1152MAF488 Recombinant Mouse Erbb2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Thr23-Thr653
Mouse Erbb2-1152MAF555 Recombinant Mouse Erbb2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Thr23-Thr653
Mouse Erbb2-2514MAF555 Recombinant Mouse Erbb2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 872
Mouse ERBB2-288M Recombinant Mouse ERBB2 Protein, His-tagged HEK293 His 711
Mouse Erbb2-969M Recombinant Mouse Erbb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Erbb2-1152MF Recombinant Mouse Erbb2 Protein, His-tagged, FITC conjugated HEK293 His Thr23-Thr653
Mouse Erbb2-2514MAF488 Recombinant Mouse Erbb2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 872
Mouse Erbb2-1152MAF647 Recombinant Mouse Erbb2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Thr23-Thr653
Mouse Erbb2-2514MP Recombinant Mouse Erbb2 protein, Fc-tagged, R-PE labeled HEK293 Fc
Mouse Erbb2-2514MA Recombinant Mouse Erbb2 protein, Fc-tagged, APC labeled HEK293 Fc
Rat Erbb2-4097RP Recombinant Rat Erbb2 protein, Fc-tagged, R-PE labeled HEK293 Fc
Rat Erbb2-1896R Recombinant Rat Erbb2 protein, His & GST-tagged E.coli His/GST Phe380-Gly582 (Accession # Q8K3F9)
Rat Erbb2-4097R Recombinant Rat Erbb2, Fc tagged Human Cell Fc
Rat Erbb2-4098R Active Recombinant Rat Erbb2 protein, His-tagged HEK293 His Met4-Thr656
Rat Erbb2-4099R Recombinant Rat ErbB2 protein HEK293 N/A Met4-Thr656
Rat ERBB2-2010RCL Recombinant Rat ERBB2 cell lysate Human Cell N/A
Rat Erbb2-4097RAF488 Recombinant Rat Erbb2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 872
Rat Erbb2-4097RA Recombinant Rat Erbb2 protein, Fc-tagged, APC labeled HEK293 Fc
Rat Erbb2-4097RAF555 Recombinant Rat Erbb2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 872
Rat Erbb2-2120R Recombinant Rat Erbb2 Protein, His-tagged E.coli His
Rat Erbb2-4098RAF555 Recombinant Rat Erbb2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 642
Rat Erbb2-4098RAF488 Recombinant Rat Erbb2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 642
Rat Erbb2-4099RAF555 Recombinant Rat Erbb2 Protein, None-tagged, Alexa Fluor 555 conjugated HEK293 LEVLFQ 638
Rat Erbb2-4099RAF488 Recombinant Rat Erbb2 Protein, None-tagged, Alexa Fluor 488 conjugated HEK293 LEVLFQ 638
Rat Erbb2-4097RAF647 Recombinant Rat Erbb2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 872
Rat Erbb2-4098RAF647 Recombinant Rat Erbb2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 642
Rat Erbb2-4099RAF647 Recombinant Rat Erbb2 Protein, None-tagged, Alexa Fluor 647 conjugated HEK293 LEVLFQ 638
Rat Erbb2-4097RF Recombinant Rat Erbb2 Protein, Fc-tagged, FITC conjugated HEK293 Fc 872
Rat Erbb2-4098RF Recombinant Rat Erbb2 Protein, His-tagged, FITC conjugated HEK293 His 642
Rat Erbb2-4099RF Recombinant Rat Erbb2 Protein, None-tagged, FITC conjugated HEK293 LEVLFQ 638
Rat Erbb2-6839R Recombinant Rat Erbb2 Protein (Ala67-Val323), C-His tagged Mammalian cells C-His Ala67-Val323
Monkey ERBB2-1216CAF555 Recombinant Monkey ERBB2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 871
Monkey ERBB2-4113RAF488 Recombinant Monkey ERBB2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 640
Monkey ERBB2-1216CF Recombinant Monkey ERBB2 Protein, Fc-tagged, FITC conjugated HEK293 Fc 871
Monkey ERBB2-1216CAF488 Recombinant Monkey ERBB2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 871
Monkey ERBB2-4113RAF555 Recombinant Monkey ERBB2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 640
Monkey ERBB2-1216CAF647 Recombinant Monkey ERBB2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 871
Monkey ERBB2-4112RAF488 Recombinant Monkey ERBB2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 870
Monkey ERBB2-1217CAF488 Recombinant Cynomolgus ERBB2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Thr23-Thr652
Monkey ERBB2-1217CAF647 Recombinant Cynomolgus ERBB2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Thr23-Thr652
Monkey ERBB2-4112RAF555 Recombinant Monkey ERBB2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 870
Monkey ERBB2-1217CF Recombinant Cynomolgus ERBB2 Protein, His-tagged, FITC conjugated HEK293 His Thr23-Thr652
Monkey ERBB2-1217CAF555 Recombinant Cynomolgus ERBB2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Thr23-Thr652
Monkey ERBB2-4112RAF647 Recombinant Monkey ERBB2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 870
Monkey ERBB2-4113RAF647 Recombinant Monkey ERBB2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 640
Monkey ERBB2-4112RF Recombinant Monkey ERBB2 Protein, Fc-tagged, FITC conjugated HEK293 Fc 870
Monkey ERBB2-4113RF Recombinant Monkey ERBB2 Protein, His-tagged, FITC conjugated HEK293 His 640
Rabbit ERBB2-1913R Active Recombinant Rabbit ERBB2 protein, His-tagged HEK293 His Thr 23 - Thr 652
Dog ERBB2-171CAF488 Recombinant Canine ERBB2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met1-Thr652, 641
Dog ERBB2-171CAF555 Recombinant Canine ERBB2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met1-Thr652, 641
Dog ERBB2-171CF Recombinant Canine ERBB2 Protein, His-tagged, FITC conjugated HEK293 His Met1-Thr652, 641
Dog ERBB2-171CAF647 Recombinant Canine ERBB2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met1-Thr652, 641
Canine ERBB2-171C Active Recombinant Canine ERBB2, His-tagged HEK293 His Met1-Thr652
Cynomolgus ERBB2-1216C Active Recombinant Cynomolgus ERBB2 protein, hFc-tagged HEK293 hFc Met1-Thr652
Cynomolgus ERBB2-206C Active Recombinant Cynomolgus ERBB2, His-tagged HEK293 His Met1-Thr652
Cynomolgus ERBB2-1236C Active Recombinant Cynomolgus ERBB2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Thr23-Thr652
Cynomolgus ERBB2-1217C Recombinant Cynomolgus ERBB2 protein, His-tagged HEK293 His Thr23-Thr652
Cynomolgus ERBB2-1216CA Recombinant Cynomolgus ERBB2 protein, Fc-tagged, APC labeled HEK293 Fc
Cynomolgus ERBB2-1216CP Recombinant Cynomolgus ERBB2 protein, Fc-tagged, R-PE labeled HEK293 Fc
Cynomolgus Monkey ERBB2-001CCL Recombinant Cynomolgus ERBB2 cell lysate Human Cell N/A
Rhesus ERBB2-4113R Active Recombinant Rhesus ERBB2 protein, His-tagged HEK293 His Met1-Thr652
Rhesus Macaque ERBB2-4112R Recombinant Rhesus ERBB2, Fc tagged Human Cell Fc
Rhesus Macaque ERBB2-2008RCL Recombinant Rhesus ERBB2 cell lysate Human Cell N/A
Zebrafish ERBB2-10470Z Recombinant Zebrafish ERBB2 Mammalian Cell His
Chicken ERBB2-3453C Recombinant Chicken ERBB2 Mammalian Cell His
ERBB2-01 Recombinant HER2/neu (478-584) E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ERBB2 involved in several pathways and played different roles in them. We selected most pathways ERBB2 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayPAK6;AKT3A;NRG2B;PTK2AB;PTK2;BAD;CAMK2B1;HRASA;RAF1B
Calcium signaling pathwayHTR2C;PLCD3A;RYR1B;NOS3;RYR2;AKR1C1;CHRM2A;PLCB2;HRH1
HIF- signaling pathwayMAPK3;Trf;RBX1;TCEB1;AKT1;ANGPT1;INS2;PRKCB;IGF1R
Focal adhesionIGF1;ITGB1;LAMB2;RHOAA;RAP1B;ITGB3B;LAMB1;MYL9;PIK3R3B
Adherens junctionCTNNB1;PVRL3;SSX2IPA;Fert2;CSNK2A2;NLK1;RHOA;ACTN2B;CSNK2A2A
Pathways in cancerFZD1;WNT7A;MAPK9;HRAS;LPAR2;FGF16;APPL1;PIAS2;COL4A1
Proteoglycans in cancerPPP1R12A;MDM2;MAP2K2;SDC2;ROCK2;PTCH1;PDPK1;WNT8B;WNT7B
MicroRNAs in cancerCD44;CDCA5;MAPK7;PTEN;ABCB1;ZFPM2;CCNE1;ABCB1A;PLCG2
Pancreatic cancerMAPK3;KRAS;RAD51;TRP53;MAPK8;IKBKB;IKBKG;TGFBR1;ERBB2
Endometrial cancerPIK3R5;APC2;CCND1;MAP2K1;CDH1;SOS1;BRAF;ARAF;AXIN2
Prostate cancerFOXO1;CCND1;Ar;PDGFC;MAPK3;BRAF;PDGFB;ARID1A;AKT1
Bladder cancerDAPK3;ARAF;MAP2K2;MAPK1;E2F1;CDK4;RB1;MMP1;HBEGF
Non-small cell lung cancerEML4;RASSF5;PIK3CD;PIK3R5;SOS1;PIK3CG;MAPK1;PRKCA;PIK3R1
Central carbon metabolism in cancerPGAM1;SLC1A5;SIRT6;FGFR1;PFKP;RAF1;PDK1;PTEN;AKT1

ERBB2 has several biochemical functions, for example, ATP binding, ErbB-3 class receptor binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB2 itself. We selected most functions ERBB2 had, and list some proteins which have the same functions with ERBB2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTTLL6;CHD1;LTK;ERCC3;DDX5;SUCLG1;UBA1;P2RX2;MYO1F
ErbB-3 class receptor bindingERBB2;NRG1;PIK3R1;CDK5
Hsp90 protein bindingCHORDC1;ERBB2;PACRG;UNC45B;USP19;AHR;EIF2AK3;NPAS2;CSNK2A1
RNA polymerase I core binding
glycoprotein bindingDNAJC5;SDC1;TFRC;RGMA;LMAN2;RASA1;SHB;LRRK2;SERPINA1D
contributes_to growth factor bindingTGFBR1;ERBB2;IL6ST;ACVR1B
identical protein bindingMCM6;SSNA1;ALAD;IFI203;DYNLT3;HSD17B10;ZHX2;SNCAIP;STAT2
protein C-terminus bindingTOP2A;ATP1B1;PEX5;ERCC6;PICK1;ATP2A2;MIF4GD;EFHC1;PPP1R9B
protein bindingTIMP1;JUB;CASP8;NMNAT1;RELA;FTL;MYH9;CST9L;CCT3
protein dimerization activityMYCL1;NHLH2;LDB1A;HPSE;EBF2;TFE3A;ABCG1;NEUROG2;PDCD6
protein heterodimerization activityCENPW;TENM2;SYT10;HIST1H4H;PVALB;HIST1H3D;SMAD3;ITGA3;MAFGA
protein phosphatase bindingPIK3R2;EGFR;DRD1A;ERBB2;ANAPC5;RPA2;JUPA;SNX3;CDKN1B
protein tyrosine kinase activityFert2;TTK;SYK;ABL2;EPHB2B;EPHB3A;ERBB4A;EPHB4B;TNK1
receptor signaling protein tyrosine kinase activityTYRO3;ERBB2;ERBB4;KITA;LYN;INSR;EGFR;KIT;SYK
transmembrane receptor protein tyrosine kinase activityERBB4;KITB;EPHB4B;FLT3;ERBB2;INSRB;ROR2;EPHB3A;TEK
transmembrane signaling receptor activityIL11RA;OR4F29;NCR2;CELSR1;CD79A;IL4R.1;ERBB3;TNFRSF10D;CD27
ubiquitin protein ligase bindingUBE2O;CUL4A;POU5F1;AMBRA1;UBE2G2;BID;YWHAZ;HSPA1L;RPA3

ERBB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB2.

ERBB3

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Do you have a recommended protocol for immobilizing any avi-tagged recombinant proteins on a streptavidin coated plate? 02/01/2023

1.Prepare the streptavidin-coated plate by washing it with PBS (phosphate-buffered saline) or another suitable buffer to remove any impurities. 2.Dilute the Avi-tagged protein in the desired buffer at the desired concentration. It is important to use a buffer that is compatible with the protein and does not interfere with its activity or stability. 3.Add the diluted protein to the streptavidin-coated plate and incubate it for a suitable amount of time at room temperature or 4°C. The exact conditions will depend on the specific protein and the desired level of immobilization. 4.Wash the plate with a suitable buffer to remove any unbound protein. 5.Block the remaining binding sites on the plate with a suitable blocking agent such as BSA (bovine serum albumin) or casein. 6.Wash the plate again to remove any unbound blocking agent. 7.Use the immobilized protein for further experiments such as ELISA, Western blotting, or other assays.

What is the primary role of ERBB2 in cell signaling? 08/12/2022

ERBB2 is a receptor tyrosine kinase involved in the regulation of cell growth and differentiation.

What therapeutic agents target ERBB2 in cancer treatment? 10/03/2020

Therapeutic agents targeting ERBB2 include trastuzumab and lapatinib.

In which types of cancer is ERBB2 commonly overexpressed? 05/12/2020

ERBB2 is commonly overexpressed in breast, ovarian, and stomach cancers.

How does ERBB2 overexpression affect patient prognosis in cancer? 05/04/2019

ERBB2 overexpression is often associated with aggressive disease and poor prognosis.

How can ERBB2 levels be assessed in a clinical setting? 08/27/2018

ERBB2 levels can be assessed using immunohistochemistry and fluorescence in situ hybridization (FISH) in tissue samples.

How is ERBB2 involved in cell growth and proliferation? 08/07/2018

It forms heterodimers with other ERBB receptors, activating pathways that promote cell growth and survival.

Are there known genetic mutations that lead to ERBB2 overexpression? 02/22/2018

Amplification of the ERBB2 gene leads to its overexpression in cancer cells.

Customer Reviews (3)

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Reviews
05/09/2022

    Worked as expected, satisfied.

    03/16/2022

      Reliable in protein assays.

      09/27/2020

        Quick and reliable shipping.

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