Recombinant Mouse IL2 Protein
Cat.No. : | IL2-79M |
Product Overview : | Recombinant Mouse Interleukin-2 is produced by our E.coli expression system and the target gene encoding Ala21-Gln169 is expressed. |
- Specification
- Gene Information
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Description : | Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by cytokine receptors of all members of cytokine family. Mature mouse IL-2 shares 56% and 73% aa sequence identity with human and rat IL-2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity. |
Source : | E. coli |
Species : | Mouse |
Form : | Lyophilized from a 0.2 um filtered solution of 20mM Sodium Citrate, 5% Trehalose, pH4.5. |
AA Sequence : | Ala21-Gln169 |
Endotoxin : | Less than 0.1 ng/ug (1 EU/ug). |
Shipping : | Ambient |
Gene Name : | Il2 interleukin 2 [ Mus musculus (house mouse) ] |
Official Symbol : | IL2 |
Synonyms : | aldesleukin; interleukin 2; interleukin-2; IL-2; T-cell growth facter; T cell growth factor; TCGF |
Gene ID : | 16183 |
mRNA Refseq : | NM_008366.3 |
Protein Refseq : | NP_032392.1 |
UniProt ID : | P04351 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL2 promotes the formation of memory T-cells.
IL2 has a pro-tumorigenic role in the tumor microenvironment.
IL2 synergizes with IL-12 in a mixed cytokine environment.
IL2 upregulates the expression of PD-1 checkpoint inhibitors.
IL2 is rapidly internalized by activated T-cells.
IL2 induces M1 macrophage polarization.
IL2 increases blood-brain barrier permeability.
IL2's affinity for its receptor decreases under hypoxic conditions.
IL2's bioactivity is enhanced by glycosylation.
IL2 promotes the differentiation of Th17 cells.
Customer Reviews (3)
Write a reviewPotent in T-cell activation.
Suitable for cytokine assays.
High stability.
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