Active Recombinant Mouse Il5 Protein (113 aa)
Cat.No. : | Il5-353I |
Product Overview : | Recombinant mouse Interleukin-5 (rmIL-5) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 113 amino acids each. A fully biologically active molecule, rmIL-5 has a molecular mass of 26.2kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques. |
- Specification
- Gene Information
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Description : | Interleukin-5 (IL-5),produced by mast cells, T cells and eosinophils, is responsible for the activities attributed to eosinophil differentiating factor, B cell growth factor II and T cell-replacing factor (TRF). It can increase production and mobilization of eosinophils and CD34+ progenitors from the bone marrow. IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release. |
Source : | E. coli |
Species : | Mouse |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | ED50 < 2.0 ng/mL, measured by a cell proliferation assay using TF-1 Cells, corresponding to a specific activity of > 5.0 × 10^5 units/mg. |
Molecular Mass : | 26.2kDa, observed by non-reducing SDS-PAGE. |
Protein Length : | 113 |
AA Sequence : | MEIPMSTVVKETLTQLSAHRALLTS NETMRLPVPTHKNHQLCIGEIFQGL DILKNQTVRGGTVEMLFQNLSLIKK YIDRQKEKCGEERRRTRQFLDYLQE FLGVMSTEWAMEG |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% by SDS-PAGE and HPLC analyses. |
Storage : | Lyophilized recombinant mouse Interleukin-5 (rmIL-5) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rmIL-5 should be stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O at 100 μg/mL. |
Gene Name : | Il5 interleukin 5 [ Mus musculus ] |
Official Symbol : | Il5 |
Synonyms : | IL5; interleukin 5; interleukin-5; TRF; BCGF-II; B-cell growth factor II; T-cell replacing factor; cytotoxic T-lymphocyte inducer; eosinophil differentiation factor; Il-5; |
Gene ID : | 16191 |
mRNA Refseq : | NM_010558 |
Protein Refseq : | NP_034688 |
UniProt ID : | P04401 |
Products Types
◆ Recombinant Protein | ||
Il5-2097M | Recombinant Mouse Il5 Protein | +Inquiry |
Il5-07M | Active Recombinant Mouse Il5 Protein, His-tagged | +Inquiry |
Il5-111M | Active Recombinant Mouse Il5 Protein | +Inquiry |
IL5-1044C | Recombinant Chicken IL5 Protein, His-tagged | +Inquiry |
IL5-2074R | Recombinant Rhesus Macaque IL5 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL5-456CCL | Recombinant Canine IL5 cell lysate | +Inquiry |
IL5-496MCL | Recombinant Mouse IL5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionInhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.
IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.
Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.
Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.
IL5 cannot be administered orally, only by injection or intravenous drip.
IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.
Customer Reviews (3)
Write a reviewHigh efficacy and safety in clinical treatment.
There are no structural or functional defects.
The stability and activity are maintained well during long-term storage.
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