| Description : |
The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. |
| Source : |
E. coli |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Liquid |
| AA Sequence : |
MGSSHHHHHHSSGLVPRGSHMNAAA EAEFNMGSSHHHHHHSSGLVPRGSH MNAAA EAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVR KVKYEETVFYGLQYILNKYLKGKVV TKEKIQEAKEVYREHFQDDVFNERG WNYILEKYDGHLPIEVKAVPEGSVI PRGNVLFTVENTDPECYWLTNWIET ILVQSWYPITVATNSREQKKILAKY LLETSGNLDGLEYKLHDFGYRGVSS QETAGIGASAHLVNFKGTDTVAGIA LIKKYYGTKDPVPGYSVPAAEHSTI TAWGKDHEKDAFEHIVTQFSSVPVS VVSDSYDIYNACEKIWGEDLRHLIV SRSTEAPLIIRPDSGNPLDTVLKVL DILGKKFPVTENSKGYKLLPPYLRV IQGDGVDINTLQEIVEGMKQKKWSI ENVSFGSGGALLQKLTRDLLNCSFK CSYVVTNGLGVNVFKDPVADPNKRS KKGRLSLHRTPAGNFVTLEEGKGDL EEYGHDLLHTVFKNGKVTKSYSFDE VRKNAQLNIEQDVAPH |
| Purity : |
≥ 90 % pure by SDS-PAGE |
| Stability : |
Shelf life: one year from despatch. |
| Storage : |
Store (in aliquots) at -20 centigrade. Avoid repeated freezing and thawing. |
| Concentration : |
1.0 mg/mL |
| Storage Buffer : |
PBS, pH 7.4 |
