Recombinant Mouse Ntrk3, His-tagged

• Cat.No.: Ntrk3-625M
• Product Overview: Recombinant Mouse Ntrk3encoding the extracellular domain of mouse TrkC (Met 1-Thr 429) was expressed, with a C-terminal His tag. It is Expressed inHuman Cells.

Specification

• Cat. No.: Ntrk3-625M
• Description: Neurotrophic tyrosine kinase receptor type 3, also known as NT-3 growth factor receptor, TrkC tyrosine kinase, TrkC and NTRK3, is a single-pass type I membrane protein. NTRK3 belongs to the protein kinase superfamily and insulin receptor subfamily. Mouse NTRK3 is a 825 amino acid (aa) protein and is widely expressed but mainly in nervous tissue. It contains two Ig-like C2-type (immunoglobulin-like) domains, one LRR (leucine-rich) repeats and one protein kinase domain. NTRK3 is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
• Source: Human Cells.
• Purity: >95% as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70⁰C.
• Predicted N Terminal: Cys 32.
• Molecular Mass: The secreted recombinant mouse TrkC comprises 409 amino acids and has a calculated molecular mass of 46.1 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
• Formulation: Supplied as a 0.2μm filtered solution of PBS, pH 7.4.
• Reconstitution: Follow the instructions on the vial. Centrifuge the vial at 4⁰C before opening to recover the entire contents.
• Storage: Store it under sterile conditions at -70⁰C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 [ Mus musculus ]
• Synonyms: Ntrk3; neurotrophic tyrosine kinase, receptor, type 3; GP145-TrkC; NT-3 growth factor receptor; OTTMUSP00000023300; OTTMUSP00000023301; trk-C; trkC tyrosine kinase; TrkC; AW125844
• Gene ID: 18213
• mRNA Refseq: NM_008746
• Protein Refseq: NP_032772
• UniProt ID: Q6VNS1
• Chromosome Location: 7 39.0 cM
• Pathway: Neurotrophin signaling pathway
• Function: ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity