| Description : |
Enables apolipoprotein binding activity; lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to starvation; and regulation of neuron apoptotic process. Acts upstream of or within several processes, including low-density lipoprotein receptor particle metabolic process; regulation of low-density lipoprotein particle receptor catabolic process; and triglyceride metabolic process. Located in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; cerebellum; genitourinary system; liver; and telencephalon. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). |
| Source : |
HEK293 |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
72 kDa |
| Protein Length : |
694 |
| AA Sequence : |
MGTHCSAWLRWPLLPLLPPLLLLLL LLCPTGAGAQDEDGDYEELMLALPS QEDGLADEAAHVATATFRRCSKEAW RLPGTYIVVLMEETQRLQIEQTAHR LQTRAARRGYVIKVLHIFYDLFPGF LVKMSSDLLGLALKLPHVEYIEEDS FVFAQSIPWNLERIIPAWHQTEEDR SPDGSSQVEVYLLDTSIQGAHREIE GRVTITDFNSVPEEDGTRFHRQASK CDSHGTHLAGVVSGRDAGVAKGTSL HSLRVLNCQGKGTVSGTLIGLEFIR KSQLIQPSGPLVVLLPLAGGYSRIL NAACRHLARTGVVLVAAAGNFRDDA CLYSPASAPEVITVGATNAQDQPVT LGTLGTNFGRCVDLFAPGKDIIGAS SDCSTCFMSQSGTSQAAAHVAGIVA RMLSREPTLTLAELRQRLIHFSTKD VINMAWFPEDQQVLTPNLVATLPPS THETGGQLLCRTVWSAHSGPTRTAT ATARCAPEEELLSCSSFSRSGRRRG DWIEAIGGQQVCKALNAFGGEGVYA VARCCLVPRANCSIHNTPAARAGLE THVHCHQKDHVLTGCSFHWEVEDLS VRRQPALRSRRQPGQCVGHQAASVY ASCCHAPGLECKIKEHGISGPSEQV TVACEAGWTLTGCNVLPGASLTLGA YSVDNLCVARVHDTARADRTSGEAT VAAAICCRSRPSAKASWVQ |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
