Recombinant Mouse SLAMF7 Protein (23-224 aa), His-tagged

• Cat.No.: SLAMF7-2323M
• Product Overview: Recombinant Mouse SLAMF7 Protein (23-224 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Immunology. Protein Description: Partial.

Specification

• Description: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of proinflammatory cytokines.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 27.8 kDa
• Protein length: 23-224 aa
• AA Sequence: SGTLKKVAGALDGSVTFTLNITEIK VDYVVWTFNTFFLAMVKKDGVTSQS SNKERIVFPDGLYSMKLSQLKKNDS GAYRAEIYSTSSQASLIQEYVLHVY KHLSRPKVTIDRQSNKNGTCVINLT CSTDQDGENVTYSWKAVGQGDNQFH DGATLSIAWRSGEKDQALTCMARNP VSNSFSTPVFPQKLCEDAATDLTSL RG
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: Slamf7 SLAM family member 7 [ Mus musculus ]
• Official Symbol: SLAMF7
• Synonyms: SLAMF7; SLAM family member 7; novel Ly9; leukocyte cell-surface antigen; 19A; CS1; 19A24; CRACC; 4930560D03Rik
• Gene ID: 75345
• mRNA Refseq: NM_144539
• Protein Refseq: NP_653122
• UniProt ID: Q8BHK6

Reviews

07/28/2023

It has a high solubility and can be easily prepared at the desired concentration.

07/26/2021

It was found to be well active and could effectively perform the required biological activity experiments.

04/15/2020

It was observed that SLAMF7 had good crystallinity, which was conducive to crystallography research.

Q&As

What is the mechanism by which SLAMF7 protein regulates immune responses?

SLAMF7 protein is involved in regulating immune cell activation, proliferation, and transmission of background signals by binding to activating ligands, such as CD319, thereby influencing the immune response.

What is the potential of combining SLAMF7 protein with immunotherapy?

By combining with immunotherapy, such as anti-PD-1 antibodies, the immune response can be further enhanced and the anti-tumor effect can be improved. The study of SLAMF7 protein provides a new direction for the development of combinatorial therapeutic strategies.

In which tissues or cells is SLAMF7 protein expressed?

This protein is mainly expressed in the immune system, including immune cells such as plasma cells, NK cells, and activated T cells.

Does the SLAMF7 protein have a similar role in other types of cancer?

The role of SLAMF7 protein in other types of cancer is unclear, and further research is needed to determine its potential role in other cancers.

Does SLAMF7 protein have potential in the treatment of multiple myeloma?

Yes, the SLAMF7 protein has been shown to be a potential therapeutic target. A monoclonal antibody drug targeting SLAMF7 protein (Elotuzumab) has been developed for the treatment of multiple myeloma.

What is the function of SLAMF7 protein in multiple myeloma?

SLAMF7 protein interacts with NK cells in multiple myeloma and plays a role in inhibiting and controlling tumor growth by activating the anti-tumor activity of NK cells.