Recombinant Zebrafish ANPEPB

• Cat.No.: ANPEPB-5487Z
• Product Overview: Recombinant Zebrafish ANPEPB full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: anpepb alanyl (membrane) aminopeptidase b [ Danio rerio (zebrafish) ]
• Official Symbol: ANPEPB
• Gene ID: 322533
• mRNA Refseq: NM_001089325
• Protein Refseq: NP_001082794
• UniProt ID: A4FUN4

Reviews

03/21/2021

The manufacturer's responsive and knowledgeable support team is always available to answer my queries or provide guidance, ensuring that I can proceed with my research smoothly and without delays.

02/20/2020

the ANPEPB protein offers exceptional quality.

07/21/2019

This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

01/23/2018

As a researcher utilizing the ANPEPB protein in my trials, I have experienced notable advantages that contribute to the efficiency and success of my research.

02/10/2017

Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

Q&As

How is ANPEPB protein activity regulated?

ANPEPB protein activity can be regulated through various mechanisms. One important aspect is its post-translational modification. ANPEPB undergoes proteolytic cleavage of its propeptide region, which is necessary for its activation.

Is ANPEPB protein expressed in cancer cells?

ANPEPB expression has been detected in various cancer types, including breast cancer, prostate cancer, and colorectal cancer. Its expression levels can vary among different cancer subtypes and stages. ANPEPB's involvement in cancer progression, metastasis, and therapeutic response is still an active area of research.

Are there any drugs or therapies targeting ANPEPB currently in development?

The development of drugs or therapies specifically targeting ANPEPB is still in the early stages. However, research investigating ANPEPB's role in diseases like hypertension and pain processing may spur the development of novel therapeutic strategies. It is possible that future studies may explore the potential of ANPEPB-targeted therapies, but currently, there are no widely available drugs or therapies targeting ANPEPB on the market.

Can ANPEPB protein be used as a biomarker for any diseases?

Research has suggested that ANPEPB protein levels or activity may potentially serve as biomarkers for certain diseases. For example, increased ANPEPB levels have been found in the cerebrospinal fluid of patients with Alzheimer's disease, suggesting a possible role in disease pathogenesis. ANPEPB levels have also been associated with cardiovascular diseases and diabetes. However, further studies are needed to validate ANPEPB as a reliable biomarker for these conditions.

Are there any genetic variations or mutations in the ANPEPB gene?

Genetic variations and mutations in the ANPEPB gene have been reported. These variations can affect the protein's structure or function, potentially leading to altered enzyme activity or stability. Some genetic variants in ANPEPB have been associated with diseases, such as cardiovascular disorders, kidney disease, or metabolic syndrome. However, the specific impact of these genetic variations on ANPEPB function and disease susceptibility is still under investigation.

Has ANPEPB protein been targeted for therapeutic interventions?

ANPEPB protein has not been extensively targeted for therapeutic interventions. However, some studies have explored the potential therapeutic applications of ANPEPB inhibition or modulation. For example, ANPEPB inhibitors have been investigated for their potential use in the treatment of hypertension, as ANPEPB plays a role in the metabolism of angiotensin peptides involved in blood pressure regulation. Further research is needed to fully understand the therapeutic potential of targeting ANPEPB in various diseases.

Can variations in ANPEPB gene lead to any genetic disorders?

While specific genetic disorders directly linked to ANPEPB gene variations are not well-documented, changes in ANPEPB expression and function have been associated with certain diseases. For instance, alterations in ANPEPB expression have been observed in hypertensive patients, suggesting a potential role in hypertension development. Further research is needed to explore the genetic variations in the ANPEPB gene and their direct impact on disease susceptibility.

Are there any therapeutic implications of targeting ANPEPB?

Targeting ANPEPB may have therapeutic implications in certain conditions. For example, regulating ANPEPB activity could potentially help in managing hypertension by modulating the levels of bradykinin, a peptide involved in blood pressure regulation. However, further research is needed to fully understand the therapeutic potential and safety considerations of ANPEPB targeting approaches.

What are the known substrates of ANPEPB protein?

ANPEPB has a broad specificity and can act on various peptides and proteins. Some of the known substrates of ANPEPB include bradykinin, an important regulator of blood pressure; opioid peptides, which are involved in pain modulation; and enkephalins, which regulate mood and behavior. ANPEPB also acts on other peptides and proteins involved in different signaling pathways.

Are there any inhibitors or activators of ANPEPB protein?

Yes, there are inhibitors and activators that have been developed to modulate the activity of ANPEPB. For example, bestatin is a known inhibitor of ANPEPB and is commonly used in research to study the effects of ANPEPB inhibition. Other inhibitors, such as amastatin and actinonin, have also been identified. On the other hand, ANPEPB can be activated by divalent cations like zinc and cobalt. Additionally, certain peptides and proteins can also regulate the activity of ANPEPB.

Are there any animal models or knockout studies for ANPEPB?

Yes, animal models and knockout studies have been conducted to examine the role of ANPEPB in various physiological processes. Knockout studies in mice have revealed insights into the involvement of ANPEPB in blood pressure regulation and the metabolism of bradykinin and opioid peptides. These studies have helped in understanding the physiological functions of ANPEPB and its potential implications in diseases.

Is ANPEPB protein associated with any diseases or conditions?

ANPEPB has been implicated in several diseases and conditions. It has been linked to hypertension, as alterations in ANPEPB expression have been observed in hypertensive patients. ANPEPB may also play a role in pain processing, as it is involved in the degradation of some opioid peptides.

Are there any known inhibitors or activators of ANPEPB protein?

Yes, there are known inhibitors and activators of ANPEPB protein. Some natural compounds, such as curcumin and resveratrol, have been shown to inhibit ANPEPB activity. Synthetic small molecule inhibitors have also been developed and tested in preclinical studies. On the other hand, certain peptides or proteins, such as cystatin C or insulin-like growth factor binding protein 3 (IGFBP-3), have been reported to activate ANPEPB activity. These activators may modulate ANPEPB function in specific physiological contexts.

What are the potential implications of ANPEPB protein dysregulation?

Dysregulation of ANPEPB protein activity has been implicated in various diseases and pathological conditions. For example, increased ANPEPB activity has been associated with hypertension and cardiovascular disorders, as it can affect the metabolism of angiotensin peptides involved in blood pressure regulation. Dysregulated ANPEPB activity has also been observed in certain types of cancer, where it can contribute to tumor growth and metastasis by influencing peptide signaling pathways. Additionally, ANPEPB dysregulation has been implicated in inflammatory diseases, autoimmune disorders, and neurodegenerative conditions, although more research is needed to fully understand its role in these disorders.

Is ANPEPB protein involved in any other physiological processes?

Apart from its role in peptide degradation and metabolism, ANPEPB is involved in other physiological processes as well. It has been found to play a role in immune regulation and inflammation. ANPEPB can also modulate the activity of neuropeptides and neurotransmitters, potentially influencing neurological processes. However, the full extent of ANPEPB's involvement in various physiological processes is still being studied.

Are there any known interactions between ANPEPB and other proteins?

Yes, ANPEPB has been found to interact with various other proteins. For example, ANPEPB has been shown to interact with neuropeptides such as substance P and neurotensin, regulating their activity and metabolism. ANPEPB also interacts with certain enzymes involved in peptide processing, such as aminopeptidases. Furthermore, ANPEPB has been reported to interact with proteins involved in signal transduction pathways and immune regulation. The specific functional consequences of these interactions are still being investigated.

How is ANPEPB protein linked to the immune system?

ANPEPB protein has been implicated in immune system regulation and function. It can influence immune responses through its involvement in peptide processing and presentation. ANPEPB is expressed in antigen-presenting cells, such as dendritic cells and macrophages, and plays a role in antigen processing and presentation to T cells. It has been shown to contribute to the generation of specific immune responses against pathogens or antigens. ANPEPB may also participate in the degradation and regulation of immune-related peptides, influencing immune signaling pathways and immune cell function.