Recombinant Zebrafish APOEA

• Cat.No.: APOEA-2751Z
• Product Overview: Recombinant Zebrafish APOEA full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: apoea apolipoprotein Ea [ Danio rerio (zebrafish) ]
• Official Symbol: APOEA
• Gene ID: 553587
• mRNA Refseq: NM_001020565
• Protein Refseq: NP_001018401
• UniProt ID: Q503V2

Reviews

06/02/2021

The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.

03/28/2018

Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.

03/19/2018

They ensure the purity, integrity, and functionality of APOEA protein through rigorous quality control measures.

12/12/2017

the manufacturer's commitment to quality control is essential in achieving reliable and consistent outcomes

Q&As

Can the APOEA protein have an impact on metabolism and weight regulation?

Yes, the APOEA protein can influence lipid and cholesterol metabolism, which can indirectly impact weight regulation. Variations in the APOE gene have been associated with differences in lipid metabolism and body fat distribution, potentially affecting an individual's susceptibility to obesity and related metabolic disorders.

How is the APOEA protein linked to Alzheimer's disease?

The APOE4 isoform of the APOEA protein is a major genetic risk factor for late-onset Alzheimer's disease. Individuals with one copy of the APOE4 allele have an increased risk, while individuals with two copies have an even higher risk of developing the disease.

What are the different isoforms of the APOEA protein?

There are three main isoforms of the APOEA protein: APOE2, APOE3, and APOE4. These isoforms are the result of genetic variations in the APOE gene and differ in their structure and function.

Can the APOEA protein be targeted for therapeutic interventions in Alzheimer's disease?

Yes, targeting the APOEA protein is an active area of research for therapeutic interventions in Alzheimer's disease. Strategies being explored include modulating APOE expression, reducing the harmful effects of the APOE4 isoform, and developing drugs that mimic the beneficial functions of APOE2 or enhance lipid metabolism in the brain.

Can variations in the APOE gene affect response to certain medications?

Yes, variations in the APOE gene can influence an individual's response to certain medications, particularly those used to treat cardiovascular conditions. It is important to consider an individual's APOE genotype when prescribing medications to ensure optimal treatment outcomes.

Are there any dietary recommendations specific to the APOEA protein?

While there are no specific dietary recommendations solely based on the APOEA protein, a balanced and healthy diet is generally advised for optimal lipid metabolism and overall health. Consuming a diet rich in fruits, vegetables, whole grains, and lean proteins, while minimizing intake of saturated fats and cholesterol, is beneficial for maintaining proper lipid levels.

How do the different isoforms of the APOEA protein affect health?

The APOE4 isoform has been associated with an increased risk of developing several conditions, including Alzheimer's disease, cardiovascular disease, and certain types of cancer. On the other hand, the APOE2 isoform has been found to have some protective effects against certain diseases, including Alzheimer's disease.

Are there any lifestyle factors that can influence the expression or function of the APOEA protein?

Yes, certain lifestyle factors can influence the expression and function of the APOEA protein. Regular exercise has been shown to increase the expression of APOE, potentially promoting brain health and reducing the risk of neurodegenerative diseases. Additionally, maintaining a healthy weight, avoiding smoking, and managing chronic conditions such as diabetes and high blood pressure may help support proper APOE function.

Are there any drugs or treatments targeting the APOEA protein?

Currently, there are no specific drugs approved for directly targeting the APOEA protein. However, research is ongoing to develop therapies that can modulate APOE function and potentially provide therapeutic benefits in treating diseases like Alzheimer's and cardiovascular disorders.

Can the APOEA protein be measured through a blood test?

Yes, the levels of APOEA protein can be measured through a blood test. This can be useful in assessing an individual's lipid profile, determining their risk for certain diseases, and potentially guiding therapy choices.

Can lifestyle choices influence the function of the APOEA protein?

Yes, certain lifestyle choices can influence the function of the APOEA protein. Factors such as diet, physical activity, and alcohol consumption can affect lipid metabolism and consequently impact the activity of this protein. A healthy lifestyle and regular exercise can help maintain optimal APOE function.

Are there any drug treatments or interventions targeting the APOEA protein currently available?

Currently, there are no specific drug treatments or interventions that directly target the APOEA protein. However, there are drugs available that indirectly impact APOE function or downstream processes affected by APOE. For example, some cholesterol-lowering medications (such as statins) can indirectly modify APOE levels. Additionally, several ongoing clinical trials are investigating the use of different therapeutic approaches, including gene therapies and medication targeting APOE-related pathways.

Is there any ongoing research on the APOEA protein?

Yes, research on the APOEA protein is ongoing. Scientists are studying its role in various diseases and conditions, exploring potential therapeutic interventions targeting the APOE pathway, and investigating the interaction between the different isoforms of this protein and their impact on health and disease.

Does the APOEA protein have a role in brain health?

Yes, the APOEA protein plays a critical role in brain health. It is involved in various processes, including neuronal growth, repair, and maintenance, as well as cholesterol and lipid transport in the brain. The APOE4 isoform is associated with increased risk and poorer outcomes in neurodegenerative disorders, including Alzheimer's disease.

How is the APOEA protein involved in cardiovascular health?

The APOEA protein helps regulate the metabolism of cholesterol and triglycerides, which are important components in cardiovascular health. Certain variations in the APOE gene can impact the levels and activity of this protein, affecting the risk of developing cardiovascular diseases.

Can the APOEA protein be a potential biomarker for Alzheimer's disease?

The APOEA protein has been studied as a potential biomarker for Alzheimer's disease. Elevated levels of APOE in cerebrospinal fluid have been associated with the disease, and it may serve as a marker of disease progression. However, further research is needed to validate its utility as a diagnostic or prognostic biomarker.