Recombinant Zebrafish il4 protein

• Cat.No.: il4-22Z
• Product Overview: Recombinant Zebrafish il4 was expressed in Yeast.

Specification

• Description: Interleukin-4 (IL-4) induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. Overproduction of IL-4 is associated with allergies.
• Source: Yeast
• Species: Zebrafish
• Form: Lyophilized without carrier protein.
• Molecular Mass: 12.4 kDa (calculated)
• AA Sequence: SKLKIDEILL MEIIQSVNGI LNGKGEKMDL DQFIPDIYET GHYSKKTLCQ AGMALKGKIP SRSHLQRQLN AYAAYTGTGN CSVSTSGECT MKEFLEKTKA CCHYLYSAQR T (111)
• Purity: >95% as visualized by SDS-PAGE analysis.
• Applications: The zebrafish IL-4 protein can be used in cell culture, as an IL-4 ELISA Standard, and as a Western Blot Control.
• Storage: Stable for up to twelve months from date of receipt at -20 centigrade. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20 centigrade. Avoid repeated freeze/thaw cycles.
• Reconstitution: Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

Gene Information

• Gene Name: il4 interleukin 4 [ Danio rerio ]
• Official Symbol: il4
• Synonyms: il-4; il4/13b; interleukin 4/13B
• Gene ID: 100188894
• mRNA Refseq: NM_001170740
• Protein Refseq: NP_001164211
• Chromosome Location: chromosome: 14
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem
• Function: growth factor activity; interleukin-4 receptor binding