Cat.No. :	il4-22Z
Product Overview :	Recombinant Zebrafish il4 was expressed in Yeast.
Description :	Interleukin-4 (IL-4) induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. Overproduction of IL-4 is associated with allergies.
Source :	Yeast
Species :	Zebrafish
Form :	Lyophilized without carrier protein.
Molecular Mass :	12.4 kDa (calculated)
AA Sequence :	SKLKIDEILL MEIIQSVNGI LNGKGEKMDL DQFIPDIYET GHYSKKTLCQ AGMALKGKIP SRSHLQRQLN AYAAYTGTGN CSVSTSGECT MKEFLEKTKA CCHYLYSAQR T (111)
Purity :	>95% as visualized by SDS-PAGE analysis.
Applications :	The zebrafish IL-4 protein can be used in cell culture, as an IL-4 ELISA Standard, and as a Western Blot Control.
Storage :	Stable for up to twelve months from date of receipt at -20 centigrade. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution :	Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

Gene Name :	il4 interleukin 4 [ Danio rerio ]
Official Symbol :	il4
Synonyms :	il-4; il4/13b; interleukin 4/13B
Gene ID :	100188894
mRNA Refseq :	NM_001170740
Protein Refseq :	NP_001164211
Chromosome Location :	chromosome: 14
Pathway :	Cytokine-cytokine receptor interaction, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem
Function :	growth factor activity; interleukin-4 receptor binding

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