il4
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  • Official Full Name
  • Interleukin 4
  • Background
  • Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). The term interleukin derives from as a means of communication, and deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes. The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.
  • Synonyms
  • B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF1; Binetrakin; BSF-1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; IL 4; IL4_HUMAN; Il4e12; Interleukin 4, isoform 1; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MFF; MGC79402; Pitrakinra; TCGF2
Cat.#:IL4-1057HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL4 Protein (His25-Ser153), Biotinylated
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Cat.#:IL4-139HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4 Protein, His-Avi-tagged, Biotinylated
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Cat.#:IL4-921CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine IL4 Protein (His25-His132)
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Cat.#:Il4-2099HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human Il4 Protein, MYC/DDK-tagged
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Cat.#:IL4-5183HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL4 Protein, GST-tagged
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Cat.#:Il4-2098MTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il4 Protein
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Cat.#:Il4-5181MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il4 Protein
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Cat.#:Il4-4344RTag:
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat Il4 Protein
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Cat.#:IL4-1258STag:His-B2M/MYC
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep IL4 Protein, His-B2M/MYC-tagged
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Cat.#:IL4-4323OTag:
Source (Host):YeastSpecies:Ovine
Product nameRecombinant Ovine IL4 Protein
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Cat.#:IL4-468HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 4
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Cat.#:Il4-469MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 4
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Cat.#:IL4-137HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 4, His-tagged
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Cat.#:IL4-59HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 4
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Cat.#:Il4-11MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Interleukin-4
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Cat.#:Il4-96RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 4
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Cat.#:IL4-240BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 4
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Cat.#:IL4-250CTag:N/A
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken Interleukin 4
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Cat.#:IL4-84PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine Interleukin 4
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Cat.#:IL4-10HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL4 protein
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Cat.#:IL4-120HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4 Protein
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Cat.#:IL4-138HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4, His tagged
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Cat.#:IL4-14204HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL4, GST-tagged
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Cat.#:IL4-1557HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human IL4, Active, His-tagged
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Cat.#:IL4-2755HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL4
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Cat.#:IL4-279HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4, StrepII-tagged
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Cat.#:IL4-27HTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Human
Product nameRecombinant Human IL4, His-tagged
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Cat.#:IL4-29002THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL4, His-tagged
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Cat.#:IL4-313HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL4, Fc-tagged
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Cat.#:IL4-360HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL4, MIgG2a Fc-tagged
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Cat.#:IL4-361HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL4, HIgG1 Fc-tagged, mutant
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Cat.#:IL4-362HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human il4,HIgG1 Fc-tagged
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Cat.#:IL4-375HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL4, None tagged
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Cat.#:IL4-483HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human IL4 protein, His-tagged
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Cat.#:IL4-504HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL-4
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Cat.#:IL4-8863HTag:
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant Human IL4,His-tagged
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Cat.#:IL4-001MTag:Fc, mutant
Source (Host):CHO cellsSpecies:Mouse
Product nameRecombinant Mouse IL4, MIgG2a Fc-tagged, mutant
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Cat.#:Il4-297MTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il4
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Cat.#:Il4-315MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il4, His-tagged
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Cat.#:Il4-316MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il4, Fc-tagged
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Cat.#:IL4-353MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Il4, His tagged
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Cat.#:IL4-363HTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Human il4, MIgG2a Fc-tagged, mutant
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Cat.#:Il4-489MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Il4 protein, His-tagged
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Cat.#:Il4-517MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il4
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Cat.#:Il4-646MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il4 protein, His & GST-tagged
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Cat.#:IL4-958MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IL4 Protein
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Cat.#:IL4-3047RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL4 Protein
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Cat.#:IL4-458RTag:Fc
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Interleukin 4, HIgG1 Fc-tagged
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Cat.#:Il4-477RTag:His
Source (Host):HEK293FSpecies:Rat
Product nameRecombinant Rat Il4 protein, His-tagged
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Cat.#:Il4-577RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il4
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Cat.#:Il4-648RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il4 protein, His & GST-tagged
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Cat.#:IL4-2252RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL4 Protein, His-tagged
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Cat.#:IL4-540RTag:
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL4
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Cat.#:IL4-262CTag:Met
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine IL4, Met-tagged
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Cat.#:IL4-644DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL4 protein, His & T7-tagged
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Cat.#:IL4-18BTag:
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine IL-4
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Cat.#:IL4-1730CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL4
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Cat.#:IL4-645CTag:His/T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IL4 protein, His & T7-tagged
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Cat.#:IL4-649RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL4 protein, His-tagged
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Cat.#:IL4-698RTag:Met
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL4, Met-tagged
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Cat.#:il4-22ZTag:
Source (Host):YeastSpecies:Zebrafish
Product nameRecombinant Zebrafish il4 protein
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Cat.#:IL4-7652ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL4
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Cat.#:IL4-256ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine IL4
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Cat.#:Il4-393CTag:Met
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Il4, Met-tagged
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Cat.#:IL4-647PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL4 protein, His-tagged
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Cat.#:IL4-669ETag:
Source (Host):E. coliSpecies:Equine
Product nameRecombinant Equine IL4
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Cat.#:IL4-9291PTag:
Source (Host):CHOSpecies:Pig
Product nameRecombinant Porcine IL4
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Cat.#:IL4-5334HTag:HQ
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Interleukin 4, HQ-tagged
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Cat.#:IL4-030ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL4 (25-153aa), Met tagged
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Cat.#:IL4-409HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-4, His Tag
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Cat.#:IL4-411RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin-4
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Cat.#:IL4-593BTag:N/A
Source (Host):COS-7Species:Bovine
Product nameRecombinant Bovine Interleukin 4
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Cat.#:IL4-99HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL4
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Cat.#:IL4-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse IL4 cell lysate
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Cat.#:IL4-112HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL4 Protein
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Cat.#:IL4-150HGTag:
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human IL4 Protein
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Cat.#:IL4-93HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-4 (rDNA derived) Reference standard
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Cat.#:Il4-112MTag:
Source (Host):Species:Mouse
Product nameMouse Interleukin-4 (rDNA derived) Reference standard
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Involved Pathway

IL4 involved in several pathways and played different roles in them. We selected most pathways IL4 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCL12B; CXCR7; IFNE; IL29; VEGFB; CCL13; TNFRSF21; CLCF1; CCL11; ACVR1B
PIK-Akt signaling pathway
TSC1; MLST8; VTN; PIK3R5; RHEB; MAPK1; ANGPT1; BAD; IFNA17; ITGB8
Jak-STAT signaling pathway
IFNA17; IL-15RA; IL6; IL21; IL5; STAT1; IL10RB; M17; STAT1A; RAF1A
Hematopoietic cell lineage
CD1E, B2M; CD5; GYPA; CD1D; CD24; ITGA4; IL5; GM13305; TFRC; CD1D2
T cell receptor signaling pathway
OXSR1A; HRAS; Il2; RELA; CD28; CD4; CD40LG; LCK; CABIN1; IL5
Fc epsilon RI signaling pathway
MS4A2; IL3; MAP2K7; RAF1; MAPK11; PLA2G4A; AKT2; PLCG1; PIK3CD; VAV3
Intestinal i
HLA-DQA1; ITGA4; MADCAM1; CCL25; CD40LG; CCL27B; PIGR; HLA-DPA1; IL6; CXCL12
ne network for IgA production
HLA-DRB4; IL6; HLA-DRA; Icosl; AICDA; MAP3K14; TGFB1A; HLA-DPA1; HLA-DMA; LTBR
Leishmaniasis
HLA-DPA1; IL12B; FCGR1; Itgam&Itgb2; ITGB1; NCF2; IFNG; FCGR2A; IRAK4; MAPK12
Measles
IFNA5; Ifna15; FAS; FCGR2B; EIF2AK4; Cd209g; PIK3R2; PIK3CD; IFNA2; Ifna11
Asthma
HLA-DRB4; TNF; HLA-DRB1; HLA-DMA; IL10; HLA-DQA1; HLA-DMB; PRG2; MS4A2; H2-AA
Autoi
TG; FAS; HLA-DPB1; IFNA12; CD80; HLA-C; IFNA8; HLA-DPA1; Ifna15; HLA-B
ne thyroid disease
HLA-DMA; HLA-DPA1; HLA-DRB5; HLA-DRB3; HLA-A; CD86; PRF1; HLA-E; IFNA16; Ifna11
Inflammatory bowel disease (IBD)
IL21; TLR4; Il2; HLA-DOB; IL22; HLA-DRB4; FOXP3; HLA-DRB3; IL23; RORC
Allograft rejection
Fasl; HLA-DMB; MICA; HLA-E; HLA-A; HLA-DQA2; IL4; PRF1; TNF; HLA-DRB3

Protein Function

IL4 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4 itself. We selected most functions IL4 had, and list some proteins which have the same functions with IL4. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein CCL20B; IFNPHI2; IL6; IFNG1-1; IL36G; GDF7; LEFTY2; Cxcl15; CER1; BMP10
Function growth factor activity
Related Protein FGF18; GPI1; GPI; BDNF; AMBN; FGF5; GDF1; FGF1A; OGN; CLCF1
Function interleukin-4 receptor binding
Related Protein IL4; PIBF1
Function protein binding
Related Protein ZKSCAN1; ITSN2; BANK1; PIK3C3; PRKDC; ERO1L; SLC9A3R2; FBL; CUL1; CSF2

Interacting Protein

IL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4.
IL4R; IL2RG; IL13RA1

IL4 Related Articles

Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
Maruyama, S; Kanoh, M; et al. A novel function of interferon regulatory factor-1: inhibition of T(h)2 cells by down-regulating the Il4 gene during Listeria infection. INTERNATIONAL IMMUNOLOGY 27:143-152(2015).

IL4 Related Gene Family

IL