IL4

  • Official Full Name

    Interleukin 4

  • Overview

    Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). The term interleukin derives from as a means of communication, and deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes. The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.
  • Synonyms

    B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF1; Binetrakin; BSF-1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; IL 4; IL4_HUMAN; Il4e12; Interleukin 4, isoform 1; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MFF; MGC79402; Pitrakinra; TCGF2;

  • Recombinant Proteins
  • GMP Proteins
  • Antibody
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Bovine
  • Canine
  • Cattle
  • Chicken
  • Cotton Rat
  • Cynomolgus
  • Cynomolgus monkey
  • Dog
  • Equine
  • Ferret
  • Guinea pig
  • Hamster
  • Human
  • Lama glama
  • Mouse
  • Ovine
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Sheep
  • Zebrafish
  • Barley Grain
  • CHO
  • CHO-K1
  • COS-7 cells
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Hordeum Vulgare
  • Human
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Nicotiana Benthamiana
  • Rat
  • Wheat Germ
  • Yeast
  • Alexa Fluor 488
  • C
  • His
  • Fc
  • Fc, mutant
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|Avi
  • His|B2M|Myc
  • His|GST
  • His|T7
  • SUMO
  • HQ
  • Met
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
  • Strep II
  • Tag free
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL4-10H Active Recombinant Human IL4 protein E.coli N/A 129 amino acids
Human IL4-2755H Active Recombinant Human IL4 Yeast N/A
Human IL4-313H Active Recombinant Human IL4, Fc-tagged CHO Fc
Human IL4-138H Active Recombinant Human IL4, His tagged Human Cell His
Human IL4-27H Active Recombinant Human IL4, His-tagged Barley Grain His
Human IL4-504H Active Recombinant Human IL-4 HEK293 N/A
Human IL4-361H Active Recombinant Human IL4, HIgG1 Fc-tagged, mutant CHO Fc
Human IL4-360H Active Recombinant Human IL4, MIgG2a Fc-tagged CHO Fc
Human IL4-030E Active Recombinant Human IL4 (25-153aa), Met tagged E.coli N/A
Human IL4-468H Active Recombinant Human Interleukin 4 E.coli N/A
Human IL4-362H Active Recombinant Human il4,HIgG1 Fc-tagged CHO Fc
Human IL4-8863H Active Recombinant Human IL4,His-tagged Hordeum Vulgare N/A
Human IL4-01HG Active GMP Recombinant Human IL4 Protein CHO-K1
Human IL4-59H Recombinant Human Interleukin 4 CHO N/A
Human IL4-1557H Recombinant human IL4, Active, His-tagged Nicotiana Benthamiana His
Human IL4-279H Recombinant Human IL4, StrepII-tagged Human Cell Strep II 25-153, 129 a.a.
Human IL4-5334H Recombinant Human Interleukin 4, HQ-tagged Hordeum Vulgare HQ
Human IL4-29002TH Recombinant Human IL4, His-tagged E.coli His
Human IL4-483H Recombinant Human IL4 protein, His-tagged HEK293F His His25~Ser153
Human IL4-137H Recombinant Human Interleukin 4, His-tagged E.coli His
Human IL4-375H Recombinant Human IL4 protein, Biotinylated E.coli N/A His25-Ser153
Human IL4-409H Recombinant Human Interleukin-4, His Tag Human His
Human IL4-99H Recombinant Human IL4 protein E.coli N/A 129
Human IL4-120H Active Recombinant Human IL4 protein HEK293 N/A His 25 - Ser 153
Human IL4-14204H Recombinant Human IL4, His-tagged E.coli His 24-153 aa
Human IL4-5183H Recombinant Human IL4 Protein, GST-tagged Wheat Germ GST
Human Il4-2099H Recombinant Human Il4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IL4-112HG GMP Recombinant Human IL4 protein E.coli N/A 129
Human DMABT-H19228 Mouse Anti-IL4 Monoclonal Antibody Mouse Alexa Fluor 488
Human IL4-1057H Recombinant Human IL4 Protein (His25-Ser153), Biotinylated E.coli N/A His25-Ser153
Human IL4-203H Recombinant Active Human IL4 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL4-139H Active Recombinant Human IL4 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human IL4-178H Active Recombinant Human IL4 Protein E.coli
Human IL4-151HG Active GMP Recombinant Human IL4 protein CHO
Human IL4-0017H Recombinant Human IL4 Protein HEK293 cells
Human IL4-202H Recombinant Human IL4 Protein, His-Avi-tagged HEK293 His-Avi Met1-Ser153
Human IL4-139HGB GMP Recombinant Human IL4 Protein E.coli
Human IL4-3924H Recombinant Human IL4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL4-094I Active Recombinant Human IL4 Protein (130 aa) E.coli 130
Human IL4-001H Active Recombinant Human IL4 Protein, His-tagged HEK293 His
Human IL4-05H Recombinant Human IL4(His25-Ser153) Protein, C-Fc-tagged HEK293 Fc
Human IL4-139HG Active GMP Recombinant Human IL4 Protein E.coli
Human IL4-244I Active Recombinant Human IL4 Protein (129 aa) CHO 129
Human IL4-5677HF Recombinant Full Length Human IL4 Protein, GST-tagged In Vitro Cell Free System GST 153 amino acids
Human IL4-42H Recombinant Human IL4 Protein E.coli
Human IL4-067H Active Recombinant Human IL4 Protein E.coli
Human IL4-25HG Active Recombinant Human IL4 Protein (His25-Ser153), GMP Grade, Animal-Free E.coli His25-Ser153
Human IL22-106H Active Recombinant Human IL4 Protein E.coli His25-Ser153
Human IL4-36H Active Recombinant Human IL4 Protein, Animal Free Human cells
Human IL4-3105H Recombinant Human IL4 protein, His-SUMO-tagged E.coli His-SUMO 25-153aa
Human IL4-1177H Recombinant Human IL4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL4-0804H Recombinant Human IL4 Protein (H25-S153), Tag Free E.coli No tag H25-S153
Human IL4-92H Recombinant Human IL4 Protein Human Cell
Human IL4-08H Active Recombinant Human IL4 Protein, Pre-aliquoted E.coli His25-Ser153, with an N-terminal Met
Human IL4-93H Human Interleukin-4 (rDNA derived) Reference standard N/A
Human IL4-0805H Recombinant Human IL4 Protein (H25-S153), His tagged E.coli His H25-S153
Human IL4-1801HFL Recombinant Full Length Human IL4 Protein, C-Flag-tagged Mammalian cells Flag
Human IL4-5448H Recombinant Human IL4 protein, His-tagged Yeast His 25-153aa
Human DMABT-H19229 Rat Anti-IL4 Monoclonal Antibody Rat Alexa Fluor 488
Human IL4-06H Active Recombinant Human CSF2 and IL4 Fusion Protein, Animal Free Human cells
Human IL4-514H Recombinant Human IL4 Protein 153
Human IL4-0173H Active Recombinant Human IL4 protein, His-tagged HEK293 His His25-Ser153
Human IL4-150HG Active GMP Recombinant Human IL4 Protein HEK293 N/A
Human IL4-168H Active Recombinant Human IL4 Protein (His25-Ser153), C-His tagged, Animal-free, Carrier-free E.coli C-His His25-Ser153
Human IL4-1177H-B Recombinant Human IL4 Protein Pre-coupled Magnetic Beads HEK293
Human IL4-151H Recombinant Human IL4 Protein, C-Term, Tag Free, Biotinylated HEK293 Tag Free C-Term
Human IL4-2483H Recombinant Human IL4 Protein (His25-Ser153), C-His tagged Mammalian cells C-His His25-Ser153
Human IL4-249H Active Recombinant Human IL4 Protein E.coli Tag Free
Human IL4-2484H Recombinant Human IL4 Protein (Gly24-Ser153), C-His tagged E.coli C-His Gly24-Ser153
Human IL4-80H Recombinant Human IL4 Protein E.coli Tag free
Human IL4-2485H Recombinant Human IL4 Protein (His25-Ser153), C-His tagged E.coli C-His His25-Ser153
Mouse Il4-297M Active Recombinant Mouse Il4 CHO N/A
Mouse Il4-316M Active Recombinant Mouse Il4, Fc-tagged CHO Fc
Mouse IL4-363H Active Recombinant Human il4, MIgG2a Fc-tagged, mutant CHO Fc
Mouse IL4-001M Active Recombinant Mouse IL4, MIgG2a Fc-tagged, mutant CHO Fc, mutant
Mouse IL4-958M Active Recombinant Mouse IL4 protein E.coli N/A His23-Ser140
Mouse Il4-469M Active Recombinant Mouse Interleukin 4 E.coli N/A
Mouse Il4-01M Active Recombinant Mouse Il4 Protein, His-Tagged E.coli His
Mouse Il4-109M Active Recombinant Mouse Il4 Protein E.coli
Mouse Il4-489M Recombinant Mouse Il4 protein, His-tagged HEK293F His His21~Ser140
Mouse Il4-11M Recombinant Mouse Il4 protein E.coli N/A 121
Mouse IL4-353M Active Recombinant Mouse IL4 protein, His-tagged Insect Cells His Met 1-Ser140, Q136D, Y139D
Mouse Il4-646M Recombinant Mouse Il4 protein, His & GST-tagged E.coli His/GST His23~Ser140
Mouse Il4-315M Recombinant Mouse Il4, His-tagged E.coli His
Mouse IL4-001MCL Recombinant Mouse IL4 cell lysate Insect Cell N/A
Mouse Il4-5181M Active Recombinant Mouse Il4 Protein E.coli N/A
Mouse Il4-6747M Recombinant Mouse Il4 Protein (His23-Ser140), C-His tagged E.coli C-His His23-Ser140
Mouse Il4-110M Active Recombinant Mouse Il4 Protein HEK293
Mouse Il4-5705M Recombinant Mouse Il4 Protein (His21-Ser140), C-His tagged Mammalian cells C-His His21-Ser140
Mouse Il4-634M Active Recombinant Mouse Il4 Protein E.coli Tag Free
Mouse IL4-0175M Active Recombinant Mouse IL4 protein, His-tagged HEK293 His His21-Ser140
Mouse Il4-243I Active Recombinant Mouse Il4 Protein CHO
Mouse Il4-59M Active Recombinant Mouse Il4 Protein (HIs21-Ser140), C-His tagged, Animal-free, Carrier-free E.coli C-His HIs21-Ser140
Mouse Il4-204M Recombinant Active Mouse IL4 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il4-025I Active Recombinant Mouse Il4 Protein (120 aa) E.coli 120
Mouse Il4-112M Mouse Interleukin-4 (rDNA derived) Reference standard N/A
Mouse IL4-179M Active Recombinant Mouse IL4 Protein E.coli
Rat IL4-458R Active Recombinant Rat Interleukin 4, HIgG1 Fc-tagged CHO Fc
Rat IL4-411R Active Recombinant Rat Interleukin-4 Rat N/A
Rat Il4-96R Recombinant Rat Interleukin 4 E.coli N/A
Rat IL4-3047R Recombinant Rat IL4 Protein Mammalian Cell His
Rat Il4-577R Recombinant Rat Il4 protein E.coli N/A 125
Rat Il4-477R Recombinant Rat Il4 protein, His-tagged HEK293F His Cys25~Ser147
Rat Il4-648R Recombinant Rat Il4 protein, His & GST-tagged E.coli His/GST Asn61~Leu111 (Accession # P20096)
Rat Il4-032RG Active GMP Recombinant Rat Il4 protein HEK293 DNA sequence encoding Rat IL-4(NP_958427.1) was expressed with His tag at the C-terminal.
Rat Il4-245I Active Recombinant Rat Il4 Protein, His-tagged CHO His
Rat Il4-4344R Recombinant Rat Il4 Protein Yeast N/A 123aa
Rat IL4-2702R Recombinant Rat IL4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IL4-2702R-B Recombinant Rat IL4 Protein Pre-coupled Magnetic Beads HEK293
Rabbit IL4-698R Active Recombinant Rabbit IL4, Met-tagged E.coli Met
Rabbit IL4-649R Recombinant Rabbit IL4 protein, His-tagged E.coli His Arg26~Ser147 (Accession # Q9MZR8)
Rabbit IL4-1040R Recombinant Rabbit IL4 Protein, His-tagged HEK293F N-His Arg26-Ser147
Dog IL4-644D Recombinant Dog IL4 protein, His & T7-tagged E.coli His/T7 Gly24~His132 (Accession # O77762)
Dog IL4-3104D Recombinant Dog IL4 protein, His-tagged E.coli His 25-132aa
Bovine IL4-18B Active Recombinant Bovine IL-4 Yeast N/A
Bovine IL4-240B Active Recombinant Bovine Interleukin 4 Yeast N/A
Bovine IL4-593B Recombinant Bovine Interleukin 4 COS-7 cells N/A
Canine IL4-177C Active Recombinant Canine IL4 Protein E.coli
Canine IL4-921C Active Recombinant Canine IL4 Protein (His25-His132) E.coli N/A His25-His132
Cattle IL4-1041C Recombinant Cattle IL4 Protein, His-tagged E.coli N-His Met1-Cys135
Cattle IL4-2317C Recombinant Cattle IL4 Protein, His-tagged HEK293F N-His Lys26-Cys135
Cotton Rat Il4-393C Active Recombinant Cotton Rat Il4, Met-tagged E.coli Met
Cynomolgus IL4-0174C Active Recombinant Cynomolgus IL4 protein, Fc-tagged HEK293 Fc His25-Ser153
Cynomolgus monkey IL4-5552C Recombinant Cynomolgus monkey IL4 protein, His-tagged Yeast His 25-153aa
Cynomolgus monkey IL4-3701C Recombinant Cynomolgus monkey IL4 protein, His-tagged E.coli His 25-153aa
Equine IL4-669E Active Recombinant Equine IL4 E.coli N/A
Equine IL4-256E Active Recombinant Equine IL4 Yeast N/A
Ferret IL4-011F Recombinant Ferret IL4 Protein, Met1-His132, C-His tagged HEK293 C-His Met1-His132
Guinea pig Il4-2318G Recombinant Guinea pig Il4 Protein, His-tagged HEK293F N-His Cys25-Arg144
Guinea pig Il4-2319G Recombinant Guinea pig Il4 Protein, His-tagged E.coli N-His Cys25-Arg144
Hamster IL4-017H Recombinant Hamster IL4 Protein, Met1-Phe147, C-His tagged HEK293 C-His Met1-Phe147
Lama glama IL4-5362L Recombinant Lama glama IL4 protein, His-tagged E.coli N-His 25-133aa
Ovine IL4-4323O Recombinant Ovine IL4 Protein Yeast N/A 111aa
Porcine IL4-01P Active GMP Recombinant Porcine IL4 Protein, His-Tagged E.coli His
Porcine IL4-181P Active Recombinant Porcine IL4 Protein E.coli
Porcine IL4-180P Active Recombinant Porcine IL4 Protein E.coli
Rhesus IL4-540R Recombinant Rhesus IL4 protein E.coli N/A 129
Rhesus Macaque IL4-2252R Recombinant Rhesus monkey IL4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL4-2073R-B Recombinant Rhesus Macaque IL4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL4-2073R Recombinant Rhesus Macaque IL4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sheep IL4-1258S Recombinant Sheep IL4 Protein, His-B2M/MYC-tagged E.coli His/B2M/Myc
Sheep IL4-5449S Recombinant Sheep IL4 protein, His-tagged Yeast His 25-135aa
Zebrafish IL4-7652Z Recombinant Zebrafish IL4 Mammalian Cell His
Zebrafish il4-22Z Recombinant Zebrafish il4 protein Yeast N/A
Pig IL4-9291P Active Recombinant Porcine IL4 CHO N/A
Pig IL4-647P Recombinant Pig IL4 protein, His-tagged E.coli His His25~Cys133
Pig IL4-84P Recombinant Porcine Interleukin 4 E.coli N/A
Pig IL4-205P Recombinant Active Pig IL4 Protein, His-tagged(C-ter) E.coli His(C-ter)
Pig IL4-242I Active Recombinant Pig IL4 Protein CHO
Pig IL4-208P Active Recombinant Pig IL4 Protein (His25-Cys133), C-His tagged, Animal-free, Carrier-free E.coli C-His His25-Cys133
Chicken IL4-1730C Recombinant Chicken IL4 Mammalian Cell His
Chicken IL4-645C Recombinant Chicken IL4 protein, His & T7-tagged E.coli His/T7 Leu26~Lys136 (Accession# Q5W4U1)
Chicken IL4-250C Recombinant Chicken Interleukin 4 Yeast N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL4 involved in several pathways and played different roles in them. We selected most pathways IL4 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCSF3;BMP7;VEGFA;IL11RA2;KITB;IL1R2;IFNA21;CCL26;TSLP
PIK-Akt signaling pathwayPIK3R1;FGF12;PPP2R5A;IFNA21;ITGA8;PHLPP2;FASLG;DDIT4;Il2
Jak-STAT signaling pathwayIfna15;LEP;IFNA5;CRLF2;SOS1;IL6ST;SOCS3B;IL12B;SOCS1
Hematopoietic cell lineageKITLG;CD19;FCGR1A;IL3RA;ITGA4;HLA-DRA;IL3;CD8B;KIT
T cell receptor signaling pathwayPDCD1;PIK3CB;VAV3;PAK1;PIK3R1;NFATC1;MAPK9;CD40LG;LCP2
Fc epsilon RI signaling pathwayPIK3CA;RAC3;MAPK9;MAPK8;TNF;PIK3CB;MAPK12;AKT2;GM-CSF
Intestinal iMHC2DAB;CD80;HLA-DOA;CCL28;CXCR4A;CCL25;MAP3K14;IL4;HLA-DPB1
ne network for IgA productionCCR9A;HLA-DPB1;CXCL12A;CD80;HLA-DOB;ICOS;BMA1;HLA-DQA1;MADCAM1
LeishmaniasisIRAK1;MARCKSL1;HLA-DRB5;HLA-DRB3;TLR2;IL1A;TRAF6;PRKCB;C3
MeaslesEIF3H;OAS1;PRKCQ;TNFAIP3;TBK1;PIK3R1;SH2D1A;PIK3R3;BBC3
AsthmaHLA-DRB5;H2-AB1;RNASE3;IL3;HLA-DRB1;MS4A2;HLA-DMA;PRG2;H2-AA
AutoiIfna11;HLA-DRB3;IL5;HLA-B;IFNA1;HLA-G;H2-AA;HLA-DPB1;HLA-DRB5
ne thyroid diseaseHLA-E;FAS;Ifna15;HLA-F;IL4;CD40;HLA-DRB1;HLA-DMB;IFNA21
Inflammatory bowel disease (IBD)HLA-DPA1;TNF;STAT4;HLA-DRB4;IL18R1;RORA;TGFB3;SMAD2;IFNGR2
Allograft rejectionIL10;HLA-DQB1;HLA-DMA;HLA-DPB1;HLA-DOB;HLA-F;H2-Q10;IFNG;HLA-A

IL4 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4 itself. We selected most functions IL4 had, and list some proteins which have the same functions with IL4. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIL29;FGF2;IFNA21;Flt3l;IL28A;LFT2;KITLG;INHBA;CMTM6
growth factor activityNRTN;PROK1;GDF7;FGF1A;GDF10B;Kitl;TGFB3;FGF13;CECR1
interleukin-4 receptor bindingPIBF1;IL4
protein bindingPCGF5;SNRPD2;PNOC;COMP;TULP3;OGFR;RASL11A;ATP2B1;OSR2

IL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4.

IL4R; IL2RG; IL13RA1

Gene Family

IL

Research Area

Related articles

Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
Maruyama, S; Kanoh, M; et al. A novel function of interferon regulatory factor-1: inhibition of T(h)2 cells by down-regulating the Il4 gene during Listeria infection. INTERNATIONAL IMMUNOLOGY 27:143-152(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
10/17/2021

    By testing immunogenicity in animal models, detect whether an immune response is induced.

    11/09/2020

      The structure of the recombinant protein was analyzed by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy, and the results showed that the protein was stable.

      05/06/2020

        This protein has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.

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