IL4 Protein


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Official Full Name Interleukin 4
Background Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). The term interleukin derives from as a means of communication, and deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes. The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.
Synonyms B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF1; Binetrakin; BSF-1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; IL 4; IL4_HUMAN; Il4e12; Interleukin 4, isoform 1; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MFF; MGC79402; Pitrakinra; TCGF2
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus monkey
    • Dog
    • Equine
    • Guinea pig
    • Human
    • Mouse
    • Ovine
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Sheep
    • Zebrafish
    • Source :
    • Barley Grain
    • CHO
    • CHO-K1
    • COS-7 cells
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human
    • Human Cell
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Nicotiana Benthamiana
    • Rat
    • Wheat Germ
    • Yeast
    • Tag :
    • Alexa Fluor 488
    • Fc
    • Fc, mutant
    • GST
    • His
    • His(C-ter)
    • Avi
    • B2M
    • Myc
    • T7
    • His-Avi
    • His-SUMO
    • HQ
    • Met
    • Myc/DDK
    • DDK
    • N/A
    • N-His
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Il4-297M Recombinant Mouse Il4 CHO N/A
    Human IL4-030E Recombinant Human IL4 (25-153aa), Met tagged E.coli N/A
    Human IL4-10H Recombinant Human IL4 protein E.coli N/A
    Human IL4-138H Recombinant Human IL4, His tagged Human Cell His
    Human IL4-2755H Recombinant Human IL4 Yeast N/A
    Human IL4-27H Recombinant Human IL4, His-tagged Barley Grain His
    Human IL4-313H Recombinant Human IL4, Fc-tagged CHO Fc
    Human IL4-360H Recombinant Human IL4, MIgG2a Fc-tagged CHO Fc
    Human IL4-361H Recombinant Human IL4, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL4-362H Recombinant Human il4,HIgG1 Fc-tagged CHO Fc
    Human IL4-468H Recombinant Human Interleukin 4 E.coli N/A
    Human IL4-504H Recombinant Human IL-4 HEK293 N/A
    Human IL4-8863H Recombinant Human IL4,His-tagged Hordeum Vulgare N/A
    Mouse IL4-001M Recombinant Mouse IL4, MIgG2a Fc-tagged, mutant CHO Fc, mutant
    Mouse Il4-316M Recombinant Mouse Il4, Fc-tagged CHO Fc
    Mouse IL4-363H Recombinant Human il4, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Il4-469M Recombinant Mouse Interleukin 4 E.coli N/A
    Mouse IL4-958M Recombinant Mouse IL4 Protein E.coli N/A
    Rat IL4-411R Recombinant Rat Interleukin-4 Rat N/A
    Rat IL4-458R Recombinant Rat Interleukin 4, HIgG1 Fc-tagged CHO Fc
    Bovine IL4-18B Recombinant Bovine IL-4 Yeast N/A
    Bovine IL4-240B Recombinant Bovine Interleukin 4 Yeast N/A
    Chicken IL4-250C Recombinant Chicken Interleukin 4 Yeast N/A
    Rabbit IL4-698R Recombinant Rabbit IL4, Met-tagged E.coli Met
    Equine IL4-256E Recombinant Equine IL4 Yeast N/A
    Cotton Rat Il4-393C Recombinant Cotton Rat Il4, Met-tagged E.coli Met
    Equine IL4-669E Recombinant Equine IL4 E.coli N/A
    Pig IL4-9291P Recombinant Porcine IL4 CHO N/A
    Human IL4-01HG GMP Recombinant Human IL4 Protein CHO-K1
    Mouse Il4-01M Recombinant Mouse Il4 Protein, His-Tagged E.coli His
    Porcine IL4-01P GMP Recombinant Porcine IL4 Protein, His-Tagged E.coli His
    Human IL4-120H Recombinant Human IL4 protein HEK293
    Human IL4-137H Recombinant Human Interleukin 4, His-tagged E.coli His
    Human IL4-14204H Recombinant Human IL4, His-tagged E.coli His
    Human IL4-1557H Recombinant human IL4, Active, His-tagged Nicotiana Benthamiana His
    Human IL4-279H Recombinant Human IL4, StrepII-tagged Human Cell Strep II
    Human IL4-29002TH Recombinant Human IL4, His-tagged E.coli His
    Human IL4-375H Recombinant Human IL4, None tagged E.coli N/A
    Human IL4-409H Recombinant Human Interleukin-4, His Tag Human His
    Human IL4-483H Recombinant Human IL4 protein, His-tagged HEK293F His
    Human IL4-5334H Recombinant Human Interleukin 4, HQ-tagged Hordeum Vulgare HQ
    Human IL4-59H Recombinant Human Interleukin 4 CHO N/A
    Human IL4-99H Recombinant Human IL4 protein E.coli N/A
    Mouse Il4-11M Recombinant Mouse Il4 protein E.coli N/A
    Mouse Il4-315M Recombinant Mouse Il4, His-tagged E.coli His
    Mouse IL4-353M Recombinant Mouse Il4, His tagged Insect Cell His
    Mouse Il4-489M Recombinant Mouse Il4 protein, His-tagged HEK293F His
    Mouse Il4-646M Recombinant Mouse Il4 protein, His & GST-tagged E.coli His/GST
    Rat IL4-3047R Recombinant Rat IL4 Protein Mammalian Cell His
    Rat Il4-477R Recombinant Rat Il4 protein, His-tagged HEK293F His
    Rat Il4-577R Recombinant Rat Il4 protein E.coli N/A
    Rat Il4-648R Recombinant Rat Il4 protein, His & GST-tagged E.coli His/GST
    Rat Il4-96R Recombinant Rat Interleukin 4 E.coli N/A
    Rhesus Macaque IL4-2252R Recombinant Rhesus monkey IL4 Protein, His-tagged Mammalian Cell His
    Rhesus IL4-540R Recombinant Rhesus IL4 protein E.coli N/A
    Dog IL4-644D Recombinant Dog IL4 protein, His & T7-tagged E.coli His/T7
    Bovine IL4-593B Recombinant Bovine Interleukin 4 COS-7 cells N/A
    Chicken IL4-1730C Recombinant Chicken IL4 Mammalian Cell His
    Chicken IL4-645C Recombinant Chicken IL4 protein, His & T7-tagged E.coli His/T7
    Rabbit IL4-649R Recombinant Rabbit IL4 protein, His-tagged E.coli His
    Zebrafish il4-22Z Recombinant Zebrafish il4 protein Yeast N/A
    Zebrafish IL4-7652Z Recombinant Zebrafish IL4 Mammalian Cell His
    Sheep IL4-1258S Recombinant Sheep IL4 Protein, His-B2M/MYC-tagged E.coli His/B2M/Myc
    Pig IL4-647P Recombinant Pig IL4 protein, His-tagged E.coli His
    Pig IL4-84P Recombinant Porcine Interleukin 4 E.coli N/A
    Mouse IL4-001MCL Recombinant Mouse IL4 cell lysate Insect Cell N/A
    Human IL4-05H Recombinant Human IL4(His25-Ser153) Protein, C-Fc-tagged HEK293 Fc
    Human IL4-067H Recombinant Human IL4 Protein E. coli
    Human IL4-08H Recombinant Human IL4 Protein, Pre-aliquoted E.coli
    Rabbit IL4-1040R Recombinant Rabbit IL4 Protein, His-tagged HEK293F N-His
    Cattle IL4-1041C Recombinant Cattle IL4 Protein, His-tagged E.coli N-His
    Human IL4-203H Recombinant Active Human IL4 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il4-204M Recombinant Active Mouse IL4 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Pig IL4-205P Recombinant Active Pig IL4 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Cattle IL4-2317C Recombinant Cattle IL4 Protein, His-tagged HEK293F N-His
    Guinea pig Il4-2318G Recombinant Guinea pig Il4 Protein, His-tagged HEK293F N-His
    Guinea pig Il4-2319G Recombinant Guinea pig Il4 Protein, His-tagged E.coli N-His
    Dog IL4-3104D Recombinant Dog IL4 protein, His-tagged E.coli His
    Human IL4-3105H Recombinant Human IL4 protein, His-SUMO-tagged E.coli His-SUMO
    Cynomolgus monkey IL4-3701C Recombinant Cynomolgus monkey IL4 protein, His-tagged E.coli His
    Human IL4-42H Recombinant Human IL4 Protein E.coli
    Human IL4-5448H Recombinant Human IL4 protein, His-tagged Yeast His
    Sheep IL4-5449S Recombinant Sheep IL4 protein, His-tagged Yeast His
    Cynomolgus monkey IL4-5552C Recombinant Cynomolgus monkey IL4 protein, His-tagged Yeast His
    Human IL4-5677HF Recombinant Full Length Human IL4 Protein, GST-tagged In Vitro Cell Free System GST
    Human DMABT-H19228 Mouse Anti-IL4 Monoclonal Antibody Mouse Alexa Fluor 488
    Human DMABT-H19229 Rat Anti-IL4 Monoclonal Antibody Rat Alexa Fluor 488
    Human IL4-001H Recombinant Human IL4 Protein, His-tagged HEK293 His
    Human IL4-1057H Recombinant Human IL4 Protein (His25-Ser153), Biotinylated E.coli N/A
    Human IL4-112HG GMP Recombinant Human IL4 protein E.coli N/A
    Human IL4-139H Recombinant Human IL4 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human IL4-139HG GMP Recombinant Human IL4 Protein E. coli
    Human IL4-139HGB GMP Recombinant Human IL4 Protein E. coli
    Human IL4-150HG GMP Recombinant Human IL4 Protein HEK293 N/A
    Human IL4-151HG GMP Recombinant Human IL4 protein CHO
    Human IL4-202H Recombinant Human IL4 Protein, His-Avi-tagged HEK293 His-Avi
    Human Il4-2099H Recombinant Human Il4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL4-3924H Recombinant Human IL4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL4-5183H Recombinant Human IL4 Protein, GST-tagged Wheat Germ GST
    Human IL4-93H Human Interleukin-4 (rDNA derived) Reference standard N/A
    Mouse Il4-109M Recombinant Mouse Il4 Protein E.coli
    Mouse Il4-110M Recombinant Mouse Il4 Protein HEK293
    Mouse Il4-112M Mouse Interleukin-4 (rDNA derived) Reference standard N/A
    Mouse Il4-5181M Recombinant Mouse Il4 Protein E.coli N/A
    Rat Il4-032RG GMP Recombinant Rat Il4 protein, His-tagged HEK293 His
    Rat Il4-4344R Recombinant Rat Il4 Protein Yeast N/A
    Canine IL4-921C Recombinant Canine IL4 Protein (His25-His132) E.coli N/A
    Ovine IL4-4323O Recombinant Ovine IL4 Protein Yeast N/A

    IL4 involved in several pathways and played different roles in them. We selected most pathways IL4 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction GHRA; LEPR; IFNW1; IL17RA; CXCR2; KITLGA; CCL4L2; GM-CSF; CXCL9; IL-15RA
    PIK-Akt signaling pathway FGF20; LAMB2; FGF1; IL7R; OSM; HGF; TSC2; NOS3; FLT4; FASLG
    Jak-STAT signaling pathway IFNW1; AOX3L1; PIAS1; STAM; HRASA; IFNA17; PIAS4; CSH2; Il23a; PIK3R3
    Hematopoietic cell lineage CD8A; Il6ra; GP9; CD1D2; CD1d1; KIT; KITLG; IL1R1; CD4; IL6R
    T cell receptor signaling pathway NFATC2; VAV2; FYN; CBL; EVLB; GSK3B; MAPK3; IKBKG; TEC; CD247
    Fc epsilon RI signaling pathway GAB2; PRKCA; LAT; MAPK13; VAV2; MAPK1; NRAS; RAF1; PIK3R2; LCP2
    Intestinal i H2-AB1; TNFSF13; TGFB1A; MHC2DEB; CCL25; MHC2DAB; HLA-DMA; HLA-DOA; IL-15RA; ITGA4
    ne network for IgA production HLA-DRB5; Icosl; AICDA; CD80; MHC2A; LTBR; IL6; HLA-DOB; HLA-DMA; CXCL12B
    Leishmaniasis HLA-DRB1; HLA-DOB; HLA-DQB1; MAPK13; MARCKSL1; TRAF6; MAPK12; MAP3K7; IL12A; ELK1
    Asthma HLA-DQB1; HLA-DRB3; HLA-DOB; HLA-DRA; IL10; CCL11; IL4; HLA-DRB5; IL13; IL9
    ne thyroid disease HLA-G; HLA-DOA; HLA-A; IFNA21; CD40; CD40LG; TSHR; H2-Q10; HLA-DQA1; IFNA13
    Inflammatory bowel disease (IBD) STAT4; IL22; FOXP3; IL23; HLA-DQA1; SMAD2; NFKB1; HLA-DOB; TBX21; IL23R
    Allograft rejection HLA-DQA1; HLA-E; HLA-B; HLA-DQA2; HLA-DMA; HLA-DQB1; HLA-DRB3; Fasl; HLA-DPA1; FASLG

    IL4 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4 itself. We selected most functions IL4 had, and list some proteins which have the same functions with IL4. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CTF1; VEGFA; INHBE; IL34; TIMP1; IL25; IL29; TNF; Ifnz; AIMP1
    growth factor activity GDF11; JAG2; Fgf15; NDR2; CXCL12; FGF20; GH1; FGF8A; BMP7; CLCF1
    interleukin-4 receptor binding PIBF1; IL4
    protein binding GPR3; NFATC2; RNF43; F2R; UBXN4; VARS; RPGR; MS4A1; WHRN; Unc5b

    IL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4.

    IL4R; IL2RG; IL13RA1

    Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
    Maruyama, S; Kanoh, M; et al. A novel function of interferon regulatory factor-1: inhibition of T(h)2 cells by down-regulating the Il4 gene during Listeria infection. INTERNATIONAL IMMUNOLOGY 27:143-152(2015).


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