IL4

  • Official Full Name

    Interleukin 4

  • Overview

    Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). The term interleukin derives from as a means of communication, and deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes. The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.

  • Synonyms

    B cell growth factor 1;B cell IgG differentiation factor;B Cell Stimulatory Factor 1;BCGF1;Binetrakin;BSF-1;HCGF;Hodgkin’s Cell Growth Factor;IA Inducing Factor;IGG1 induction factor;IL 4;IL4_HUMAN;Il4e12;Interleukin 4, isoform 1;Lymphocyte stimulatory factor 1;Macrophage fusion factor;Mast cell growth factor 2;MFF;MGC79402;Pitrakinra;TCGF2

Recombinant Proteins

  • Human
  • Mouse
  • Ovine
  • Rat
  • Bovine
  • Equine
  • Cotton Rat
  • Rabbit
  • Pig
  • Cynomolgus
  • Porcine
  • Sheep
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Dog
  • Ferret
  • Hamster
  • Cattle
  • Canine
  • Guinea pig
  • Lama glama
  • Golden hamster
  • Llama
  • E.coli
  • CHO
  • HEK293
  • Yeast
  • Wheat Germ
  • Human Cells
  • Barley Grain
  • Rat
  • Hordeum Vulgare
  • C-His
  • Nicotiana Benthamiana
  • Mammalian Cells
  • Insect Cells
  • Human
  • COS-7 cells
  • Mouse
  • In Vitro Cell Free System
  • Non
  • His
  • Avi
  • GST
  • Fc
  • B2M
  • Myc
  • HQ
  • T7
  • Alexa Fluor
  • Flag
  • DDK
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
IL4-10H Active Recombinant Human IL4 protein E.coli Human Non 129 amino acids
Il4-297M Active Recombinant Mouse Il4 CHO Mouse Non
IL4-14204H Recombinant Human IL4, His-tagged E.coli Human His 24-153 aa
IL4-375H Recombinant Human IL4 protein, Biotinylated E.coli Human Non His25-Ser153
IL4-139H Recombinant Human IL4 protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His His25-Ser153
IL4-4323O Recombinant Ovine IL4 Protein Yeast Ovine Non 111aa
Il4-4344R Recombinant Rat Il4 Protein Yeast Rat Non 123aa
IL4-5183H Recombinant Human IL4 Protein, GST-tagged Wheat Germ Human GST
IL4-001M Active Recombinant Mouse IL4, MIgG2a Fc-tagged, mutant CHO Mouse Fc 21-140 a.a.
IL4-030E Active Recombinant Human IL4 (25-153aa), Met tagged E.coli Human Non
IL4-138H Active Recombinant Human IL4, His tagged Human Cells Human His 25-153 a.a.
IL4-18B Active Recombinant Bovine IL-4 Yeast Bovine Non
IL4-240B Active Recombinant Bovine Interleukin 4 Yeast Bovine Non
IL4-256E Active Recombinant Equine IL4 Yeast Equine Non
IL4-2755H Active Recombinant Human IL4 Yeast Human Non
IL4-27H Active Recombinant Human IL4, His-tagged Barley Grain Human His
IL4-313H Active Recombinant Human IL4, Fc-tagged CHO Human Fc 1-153 a.a.
Il4-316M Active Recombinant Mouse Il4, Fc-tagged CHO Mouse Fc 21-140 a.a.
IL4-360H Active Recombinant Human IL4, MIgG2a Fc-tagged CHO Human Fc 1-153 a.a.
IL4-361H Active Recombinant Human IL4, HIgG1 Fc-tagged, mutant CHO Human Fc 1-153 a.a.
IL4-362H Active Recombinant Human il4,HIgG1 Fc-tagged CHO Human Fc 1-153 a.a.
IL4-363H Active Recombinant Human il4, MIgG2a Fc-tagged, mutant CHO Mouse Fc 21-140 a.a.
Il4-393C Active Recombinant Cotton Rat Il4, Met-tagged E.coli Cotton Rat 21-147 a.a.
IL4-411R Active Recombinant Rat Interleukin-4 Rat Rat Non
IL4-458R Active Recombinant Rat Interleukin 4, HIgG1 Fc-tagged CHO Rat Fc 1-153 a.a.
IL4-468H Active Recombinant Human Interleukin 4 E.coli Human Non
Il4-469M Active Recombinant Mouse Interleukin 4 E.coli Mouse Non
IL4-504H Recombinant Human IL4 protein HEK293 Human Non His25-Ser153
IL4-669E Active Recombinant Equine IL4 E.coli Equine Non 26-137 a.a.
IL4-698R Active Recombinant Rabbit IL4, Met-tagged E.coli Rabbit 25-147 a.a.
IL4-8863H Active Recombinant Human IL4,His-tagged Hordeum Vulgare Human Non
IL4-9291P Active Recombinant Porcine IL4 CHO Pig Non
IL4-958M Active Recombinant Mouse IL4 protein E.coli Mouse Non His23-Ser140
IL4-0174C Active Recombinant Cynomolgus IL4 protein, Fc-tagged HEK293 Cynomolgus Fc 25-153 a.a.
IL4-01HG Active GMP Recombinant Human IL4 Protein CHO Human
Il4-01M Active Recombinant Mouse Il4 Protein, His-Tagged E.coli Mouse His
IL4-01P Active GMP Recombinant Porcine IL4 Protein, His-Tagged E.coli Porcine His
IL4-1512C Recombinant Cynomolgus IL4 protein, His-tagged C-His Cynomolgus His25-Ser153
IL4-158H Active Recombinant Human interleukin 4 Protein, Tag Free HEK293 Human Non 25-163aa
Il4-109M Active Recombinant Mouse Il4 Protein E.coli Mouse
Il4-11M Recombinant Mouse Il4 protein E.coli Mouse Non 121
IL4-120H Active Recombinant Human IL4 protein HEK293 Human Non His 25 - Ser 153
IL4-1258S Recombinant Sheep IL4 Protein, His-B2M/MYC-tagged E.coli Sheep B2M&His&Myc 25-135 a.a.
IL4-137H Recombinant Human Interleukin 4, His-tagged E.coli Human His
IL4-1557H Recombinant human IL4, Active, His-tagged Nicotiana Benthamiana Human His 25-153 a.a.
IL4-1730C Recombinant Chicken IL4 Mammalian Cells Chicken His
IL4-2252R Recombinant Rhesus monkey IL4 Protein, His-tagged Mammalian Cells Rhesus macaque His
il4-22Z Recombinant Zebrafish il4 protein Yeast Zebrafish Non
IL4-250C Recombinant Chicken Interleukin 4 Yeast Chicken Non
IL4-29002TH Recombinant Human IL4, His-tagged E.coli Human His Full L. 25-153 a.a.
IL4-3047R Recombinant Rat IL4 Protein Mammalian Cells Rat His
Il4-315M Recombinant Mouse Il4, His-tagged E.coli Mouse His 21-140 a.a.
IL4-353M Active Recombinant Mouse IL4 protein, His-tagged Insect Cells Mouse His Met 1-Ser140, Q136D, Y139D
IL4-409H Recombinant Human Interleukin-4, His Tag Human Human His 25-153 a.a.
Il4-477R Recombinant Rat Il4 protein, His-tagged HEK293 Rat His Cys25~Ser147
IL4-483H Recombinant Human IL4 protein, His-tagged HEK293 Human His His25~Ser153
Il4-489M Recombinant Mouse Il4 protein, His-tagged HEK293 Mouse His His21~Ser140
IL4-5334H Recombinant Human Interleukin 4, HQ-tagged Hordeum Vulgare Human HQ
IL4-540R Recombinant Rhesus IL4 protein E.coli Rhesus macaque Non 129
Il4-577R Recombinant Rat Il4 protein E.coli Rat Non 125
IL4-593B Recombinant Bovine Interleukin 4 COS-7 cells Bovine Non
IL4-59H Recombinant Human Interleukin 4 CHO Human Non
IL4-644D Recombinant Dog IL4 protein, His & T7-tagged E.coli Dog His&T7 Gly24~His132
IL4-645C Recombinant Chicken IL4 protein, His & T7-tagged E.coli Chicken His&T7 Leu26~Lys136
Il4-646M Recombinant Mouse Il4 protein, His & GST-tagged E.coli Mouse GST&His His23~Ser140
IL4-647P Recombinant Pig IL4 protein, His-tagged E.coli Pig His His25~Cys133
Il4-648R Recombinant Rat Il4 protein, His & GST-tagged E.coli Rat GST&His Asn61~Leu111
IL4-649R Recombinant Rabbit IL4 protein, His-tagged E.coli Rabbit His Arg26~Ser147
IL4-7652Z Recombinant Zebrafish IL4 Mammalian Cells Zebrafish His
IL4-84P Recombinant Porcine Interleukin 4 E.coli Pig Non
Il4-96R Recombinant Rat Interleukin 4 E.coli Rat Non
IL4-99H Recombinant Human IL4 protein E.coli Human Non 129
IL4-001MCL Recombinant Mouse IL4 cell lysate Insect Cells Mouse Non
DMABT-H19228 Mouse Anti-IL4 Monoclonal Antibody Mouse Human Alexa Fluor
DMABT-H19229 Rat Anti-IL4 Monoclonal Antibody Rat Human Alexa Fluor
IL22-106H Active Recombinant Human IL4 Protein E.coli Human His25-Ser153
IL4-0017H Recombinant Human IL4 Protein HEK293 Human
IL4-001H Active Recombinant Human IL4 Protein, His-tagged HEK293 Human His
IL4-011F Recombinant Ferret IL4 Protein, Met1-His132, C-His tagged HEK293 Ferret His Met1-His132
IL4-0173H Active Recombinant Human IL4 protein, His-tagged HEK293 Human His 25-153 a.a.
IL4-0175M Active Recombinant Mouse IL4 protein, His-tagged HEK293 Mouse His 21-140 a.a.
IL4-017H Recombinant Hamster IL4 Protein, Met1-Phe147, C-His tagged HEK293 Hamster His Met1-Phe147
Il4-025I Active Recombinant Mouse Il4 Protein (120 aa) E.coli Mouse 120
Il4-032RG Active GMP Recombinant Rat Il4 protein HEK293 Rat DNA sequence encoding Rat IL-4(NP_958427.1) was expressed with His tag at the C-terminal.
IL4-05H Recombinant Human IL4(His25-Ser153) Protein, C-Fc-tagged HEK293 Human Fc 25-153 a.a.
IL4-067H Active Recombinant Human IL4 Protein E.coli Human
IL4-06H Active Recombinant Human CSF2 and IL4 Fusion Protein, Animal Free Human Cells Human
IL4-0804H Recombinant Human IL4 Protein (H25-S153), Tag Free E.coli Human Non H25-S153
IL4-0805H Recombinant Human IL4 Protein (H25-S153), His tagged E.coli Human His H25-S153
IL4-08H Active Recombinant Human IL4 Protein, Pre-aliquoted E.coli Human His25-Ser153, with an N-terminal Met
IL4-094I Active Recombinant Human IL4 Protein (130 aa) E.coli Human 130
IL4-1040R Recombinant Rabbit IL4 Protein, His-tagged HEK293 Rabbit His Arg26-Ser147
IL4-1041C Recombinant Cattle IL4 Protein, His-tagged E.coli Cattle His Met1-Cys135
IL4-1057H Recombinant Human IL4 Protein (His25-Ser153), Biotinylated E.coli Human Non His25-Ser153
Il4-110M Active Recombinant Mouse Il4 Protein HEK293 Mouse 23-140 a.a.
IL4-112HG GMP Recombinant Human IL4 protein E.coli Human Non 129
Il4-112M Mouse Interleukin-4 (rDNA derived) Reference standard Mouse Non
IL4-1177H Recombinant Human IL4 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IL4-1177H-B Recombinant Human IL4 Protein Pre-coupled Magnetic Beads HEK293 Human
IL4-139HG Active GMP Recombinant Human IL4 Protein E.coli Human 25-153 a.a.
IL4-139HGB GMP Recombinant Human IL4 Protein E.coli Human 25-153 a.a.
Il4-144M Recombinant Mouse interleukin 4 Protein, His&Flag tagged HEK293 Mouse Flag&His 21-140aa
IL4-150HG Active GMP Recombinant Human IL4 Protein HEK293 Human Non 25-153 a.a.
IL4-151H Recombinant Human IL4 Protein, C-Term, Tag Free, Biotinylated HEK293 Human Non C-Term
IL4-151HG Active GMP Recombinant Human IL4 protein CHO Human
Il4-156R Recombinant Rat interleukin 4 Protein, His&Flag tagged HEK293 Rat Flag&His 25-147aa
IL4-168H Active Recombinant Human IL4 Protein (His25-Ser153), C-His tagged, Animal-free, Carrier-free E.coli Human His His25-Ser153
IL4-177C Active Recombinant Canine IL4 Protein E.coli Canine
IL4-178H Active Recombinant Human IL4 Protein E.coli Human
IL4-179M Active Recombinant Mouse IL4 Protein E.coli Mouse
IL4-1801HFL Recombinant Full Length Human IL4 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
IL4-180P Active Recombinant Porcine IL4 Protein E.coli Porcine
IL4-181P Active Recombinant Porcine IL4 Protein E.coli Porcine
IL4-19H Recombinant Human IL4 Protein E.coli Human
IL4-202H Recombinant Human IL4 protein, His-Avi-tagged HEK293 Human Avi&His His25-Ser153
IL4-203H Recombinant Active Human IL4 Protein, His-tagged(C-ter) E.coli Human His
Il4-204M Recombinant Active Mouse IL4 Protein, His-tagged(C-ter) E.coli Mouse His
IL4-205P Recombinant Active Pig IL4 Protein, His-tagged(C-ter) E.coli Pig His
IL4-2073R Recombinant Rhesus Macaque IL4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IL4-2073R-B Recombinant Rhesus Macaque IL4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IL4-208P Active Recombinant Pig IL4 Protein (His25-Cys133), C-His tagged, Animal-free, Carrier-free E.coli Pig His His25-Cys133
Il4-2099H Recombinant Human Il4 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
IL4-2317C Recombinant Cattle IL4 Protein, His-tagged HEK293 Cattle His Lys26-Cys135
Il4-2318G Recombinant Guinea pig Il4 Protein, His-tagged HEK293 Guinea pig His Cys25-Arg144
Il4-2319G Recombinant Guinea pig Il4 Protein, His-tagged E.coli Guinea pig His Cys25-Arg144
IL4-242I Active Recombinant Pig IL4 Protein CHO Pig
Il4-243I Active Recombinant Mouse Il4 Protein CHO Mouse
IL4-244I Active Recombinant Human IL4 Protein (129 aa) CHO Human 129
Il4-244M Recombinant Mouse interleukin 4 Protein, Tag Free HEK293 Mouse Non 21-140aa
Il4-245I Active Recombinant Rat Il4 Protein, His-tagged CHO Rat His
IL4-2483H Recombinant Human IL4 Protein (His25-Ser153), C-His tagged Mammalian Cells Human His His25-Ser153
IL4-2484H Recombinant Human IL4 Protein (Gly24-Ser153), C-His tagged E.coli Human His Gly24-Ser153
IL4-2485H Recombinant Human IL4 Protein (His25-Ser153), C-His tagged E.coli Human His His25-Ser153
IL4-249H Active Recombinant Human IL4 Protein E.coli Human Non
IL4-25HG Active Recombinant Human IL4 Protein (His25-Ser153), GMP Grade, Animal-Free E.coli Human His25-Ser153
IL4-2702R Recombinant Rat IL4 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
IL4-2702R-B Recombinant Rat IL4 Protein Pre-coupled Magnetic Beads HEK293 Rat
IL4-3104D Recombinant Dog IL4 protein, His-tagged E.coli Dog His 25-132aa
IL4-3105H Recombinant Human IL4 protein, His-SUMO-tagged E.coli Human His&SUMO 25-153aa
IL4-36H Active Recombinant Human IL4 Protein, Animal Free Human Cells Human
IL4-3701C Recombinant Cynomolgus monkey IL4 protein, His-tagged E.coli Cynomolgus His 25-153aa
IL4-3924H Recombinant Human IL4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IL4-42H Recombinant Human IL4 Protein E.coli Human Full L.
IL4-514H Recombinant Human IL4 Protein Human 153
Il4-5181M Active Recombinant Mouse Il4 Protein E.coli Mouse Non 21-140 a.a.
IL4-5362L Recombinant Lama glama IL4 protein, His-tagged E.coli Lama glama His 25-133aa
IL4-5448H Recombinant Human IL4 protein, His-tagged Yeast Human His 25-153aa
IL4-5449S Recombinant Sheep IL4 protein, His-tagged Yeast Sheep His 25-135aa
IL4-5552C Recombinant Cynomolgus monkey IL4 protein, His-tagged Yeast Cynomolgus His 25-153aa
IL4-5677HF Recombinant Full Length Human IL4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 153 amino acids
Il4-5705M Recombinant Mouse Il4 Protein (His21-Ser140), C-His tagged Mammalian Cells Mouse His His21-Ser140
Il4-59M Active Recombinant Mouse Il4 Protein (HIs21-Ser140), C-His tagged, Animal-free, Carrier-free E.coli Mouse His HIs21-Ser140
IL4-6332G Recombinant Golden hamster IL4 protein, His-tagged Yeast Golden hamster His 20-147aa
Il4-634M Active Recombinant Mouse Il4 Protein E.coli Mouse Non
Il4-6747M Recombinant Mouse Il4 Protein (His23-Ser140), C-His tagged E.coli Mouse His His23-Ser140
IL4-674L Recombinant Llama IL4 protein, His-tagged Yeast Llama His 25-133aa
IL4-80H Recombinant Human IL4 Protein E.coli Human Non
IL4-921C Active Recombinant Canine IL4 Protein (His25-His132) E.coli Canine Non His25-His132
IL4-92H Recombinant Human IL4 Protein Human Cells Human 25-153 a.a.
IL4-93H Human Interleukin-4 (rDNA derived) Reference standard Human Non

    Involved Pathway

    IL4 involved in several pathways and played different roles in them. We selected most pathways IL4 participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CXCL12A,TNFRSF6B,CCR5,LIFRA,IL20,IFNA6,IL12B,CCL19,IL19,IL23
    Inflammatory bowel disease (IBD) Il23a; Il12b,Il23a,IL4R,STAT6,HLA-DMA,HLA-DQA1,FOXP3,STAT3,MAF,H2-AB1
    Jak-STAT signaling pathway IL11RA,CSH1,THPO,STAT5A,IFNA1,IFNE,IL6ST,IFNPHI1,IL2RG,GM2002
    Autoi H2-AA,PRF1,Ifna15,Ifna11,IFNA13,IFNA7,IFNA16,IFNA14,HLA-DOA,HLA-DRB1
    T cell receptor signaling pathway VAV1,PIK3CA,PPP3CC,CARD11,CD40LG,NRAS,MUC1,IL5,LAT,IKBKB
    ne network for IgA production HLA-DRA,CD86,CXCR4B,PIGR,BMA2,CD40,ICOS,ITGA4,CXCL12A,MHC2DEB
    ne thyroid disease IFNA4,Il2,HLA-DRA,IFNA6,FASLG,HLA-DQB1,IFNA1,IFNA12,IFNA7,GZMB
    Leishmaniasis PRKCB,HLA-DQA1,FCGR3B,FCGR2C,TGFB1,CR1,ITGB1,NFKBIA,TNF,IL1A
    PIK-Akt signaling pathway IBSP,LPAR6,LAMB2,GNG5,IFNA17,ITGB7,STK11,IL2RB,CREB5,PDGFB

    Protein Function

    IL4 has several biochemical functions, for example, cytokine activity,growth factor activity,interleukin-4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4 itself. We selected most functions IL4 had, and list some proteins which have the same functions with IL4. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-4 receptor binding PIBF1
    protein binding USP5,SIGLEC8,S100A10,DDX3X,UBA2,PPP4R4,SULT4A1,KLHDC4,DSCC1,RND1
    cytokine activity CSF3,CMTM5,TXLNA,SLURP1,Il23a; Il12b,IL36A,IL17F,IFNA3,IL20,IL17A/F1
    growth factor activity IL5,IL8L2,OSM,THPO,FGF18A,GMFB,IL6,Il2,PRL2C3,NENF

    Interacting Protein

    IL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4.

    IL4R;IL2RG;IL13RA1

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family
    Growth Factors

    References

    • Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
    • Maruyama, S; Kanoh, M; et al. A novel function of interferon regulatory factor-1: inhibition of T(h)2 cells by down-regulating the Il4 gene during Listeria infection. INTERNATIONAL IMMUNOLOGY 27:143-152(2015).

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