IL4 Protein

IL4

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IL4

Official Full Name Interleukin 4
Background Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). The term interleukin derives from as a means of communication, and deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes. The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.
Synonyms B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF1; Binetrakin; BSF-1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; IL 4; IL4_HUMAN; Il4e12; Interleukin 4, isoform 1; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MFF; MGC79402; Pitrakinra; TCGF2
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus monkey
    • Dog
    • Equine
    • Guinea pig
    • Human
    • Mouse
    • Ovine
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Sheep
    • Zebrafish
    • Source :
    • Barley Grain
    • CHO
    • CHO-K1
    • COS-7 cells
    • E. coli
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human
    • Human Cell
    • Human cells
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Nicotiana Benthamiana
    • Rat
    • Wheat Germ
    • Yeast
    • Tag :
    • Alexa Fluor 488
    • Fc
    • Fc, mutant
    • Flag
    • GST
    • His
    • His(C-ter)
    • Avi
    • B2M
    • Myc
    • T7
    • His-Avi
    • His-SUMO
    • HQ
    • Met
    • Myc/DDK
    • DDK
    • N/A
    • N-His
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Il4-297M Active Recombinant Mouse Il4 CHO N/A Inquiry
    Human IL4-030E Active Recombinant Human IL4 (25-153aa), Met tagged E.coli N/A Inquiry
    Human IL4-10H Active Recombinant Human IL4 protein E.coli N/A Inquiry
    Human IL4-138H Active Recombinant Human IL4, His tagged Human Cell His Inquiry
    Human IL4-2755H Active Recombinant Human IL4 Yeast N/A Inquiry
    Human IL4-27H Active Recombinant Human IL4, His-tagged Barley Grain His Inquiry
    Human IL4-313H Active Recombinant Human IL4, Fc-tagged CHO Fc Inquiry
    Human IL4-360H Active Recombinant Human IL4, MIgG2a Fc-tagged CHO Fc Inquiry
    Human IL4-361H Active Recombinant Human IL4, HIgG1 Fc-tagged, mutant CHO Fc Inquiry
    Human IL4-362H Active Recombinant Human il4,HIgG1 Fc-tagged CHO Fc Inquiry
    Human IL4-468H Active Recombinant Human Interleukin 4 E.coli N/A Inquiry
    Human IL4-504H Active Recombinant Human IL-4 HEK293 N/A Inquiry
    Human IL4-8863H Active Recombinant Human IL4,His-tagged Hordeum Vulgare N/A Inquiry
    Mouse IL4-001M Active Recombinant Mouse IL4, MIgG2a Fc-tagged, mutant CHO Fc, mutant Inquiry
    Mouse Il4-316M Active Recombinant Mouse Il4, Fc-tagged CHO Fc Inquiry
    Mouse IL4-363H Active Recombinant Human il4, MIgG2a Fc-tagged, mutant CHO Fc Inquiry
    Mouse Il4-469M Active Recombinant Mouse Interleukin 4 E.coli N/A Inquiry
    Mouse IL4-958M Active Recombinant Mouse IL4 Protein E.coli N/A Inquiry
    Rat IL4-411R Active Recombinant Rat Interleukin-4 Rat N/A Inquiry
    Rat IL4-458R Active Recombinant Rat Interleukin 4, HIgG1 Fc-tagged CHO Fc Inquiry
    Bovine IL4-18B Active Recombinant Bovine IL-4 Yeast N/A Inquiry
    Bovine IL4-240B Active Recombinant Bovine Interleukin 4 Yeast N/A Inquiry
    Rabbit IL4-698R Active Recombinant Rabbit IL4, Met-tagged E.coli Met Inquiry
    Equine IL4-256E Active Recombinant Equine IL4 Yeast N/A Inquiry
    Cotton Rat Il4-393C Active Recombinant Cotton Rat Il4, Met-tagged E.coli Met Inquiry
    Equine IL4-669E Active Recombinant Equine IL4 E.coli N/A Inquiry
    Pig IL4-9291P Active Recombinant Porcine IL4 CHO N/A Inquiry
    Human IL4-01HG Active GMP Recombinant Human IL4 Protein CHO-K1 Inquiry
    Mouse Il4-01M Active Recombinant Mouse Il4 Protein, His-Tagged E.coli His Inquiry
    Porcine IL4-01P Active GMP Recombinant Porcine IL4 Protein, His-Tagged E.coli His Inquiry
    Human IL4-120H Recombinant Human IL4 protein HEK293 Inquiry
    Human IL4-137H Recombinant Human Interleukin 4, His-tagged E.coli His Inquiry
    Human IL4-14204H Recombinant Human IL4, His-tagged E.coli His Inquiry
    Human IL4-1557H Recombinant human IL4, Active, His-tagged Nicotiana Benthamiana His Inquiry
    Human IL4-279H Recombinant Human IL4, StrepII-tagged Human Cell Strep II Inquiry
    Human IL4-29002TH Recombinant Human IL4, His-tagged E.coli His Inquiry
    Human IL4-375H Recombinant Human IL4, None tagged E.coli N/A Inquiry
    Human IL4-409H Recombinant Human Interleukin-4, His Tag Human His Inquiry
    Human IL4-483H Recombinant Human IL4 protein, His-tagged HEK293F His Inquiry
    Human IL4-5334H Recombinant Human Interleukin 4, HQ-tagged Hordeum Vulgare HQ Inquiry
    Human IL4-59H Recombinant Human Interleukin 4 CHO N/A Inquiry
    Human IL4-99H Recombinant Human IL4 protein E.coli N/A Inquiry
    Mouse Il4-11M Recombinant Mouse Il4 protein E.coli N/A Inquiry
    Mouse Il4-315M Recombinant Mouse Il4, His-tagged E.coli His Inquiry
    Mouse IL4-353M Recombinant Mouse Il4, His tagged Insect Cell His Inquiry
    Mouse Il4-489M Recombinant Mouse Il4 protein, His-tagged HEK293F His Inquiry
    Mouse Il4-646M Recombinant Mouse Il4 protein, His & GST-tagged E.coli His/GST Inquiry
    Rat IL4-3047R Recombinant Rat IL4 Protein Mammalian Cell His Inquiry
    Rat Il4-477R Recombinant Rat Il4 protein, His-tagged HEK293F His Inquiry
    Rat Il4-577R Recombinant Rat Il4 protein E.coli N/A Inquiry
    Rat Il4-648R Recombinant Rat Il4 protein, His & GST-tagged E.coli His/GST Inquiry
    Rat Il4-96R Recombinant Rat Interleukin 4 E.coli N/A Inquiry
    Rhesus Macaque IL4-2252R Recombinant Rhesus monkey IL4 Protein, His-tagged Mammalian Cell His Inquiry
    Rhesus IL4-540R Recombinant Rhesus IL4 protein E.coli N/A Inquiry
    Dog IL4-644D Recombinant Dog IL4 protein, His & T7-tagged E.coli His/T7 Inquiry
    Bovine IL4-593B Recombinant Bovine Interleukin 4 COS-7 cells N/A Inquiry
    Chicken IL4-1730C Recombinant Chicken IL4 Mammalian Cell His Inquiry
    Chicken IL4-250C Recombinant Chicken Interleukin 4 Yeast N/A Inquiry
    Chicken IL4-645C Recombinant Chicken IL4 protein, His & T7-tagged E.coli His/T7 Inquiry
    Rabbit IL4-649R Recombinant Rabbit IL4 protein, His-tagged E.coli His Inquiry
    Zebrafish il4-22Z Recombinant Zebrafish il4 protein Yeast N/A Inquiry
    Zebrafish IL4-7652Z Recombinant Zebrafish IL4 Mammalian Cell His Inquiry
    Sheep IL4-1258S Recombinant Sheep IL4 Protein, His-B2M/MYC-tagged E.coli His/B2M/Myc Inquiry
    Pig IL4-647P Recombinant Pig IL4 protein, His-tagged E.coli His Inquiry
    Pig IL4-84P Recombinant Porcine Interleukin 4 E.coli N/A Inquiry
    Mouse IL4-001MCL Recombinant Mouse IL4 cell lysate Insect Cell N/A Inquiry
    Human IL22-106H Recombinant Human IL4 Protein E.coli Inquiry
    Human IL4-0017H Recombinant Human IL4 Protein HEK293 cells Inquiry
    Mouse Il4-025I Recombinant Mouse Il4 Protein (120 aa) E.coli Inquiry
    Human IL4-05H Recombinant Human IL4(His25-Ser153) Protein, C-Fc-tagged HEK293 Fc Inquiry
    Human IL4-067H Recombinant Human IL4 Protein E. coli Inquiry
    Human IL4-06H Recombinant Human CSF2 and IL4 Fusion Protein, Animal Free Human cells Inquiry
    Human IL4-08H Recombinant Human IL4 Protein, Pre-aliquoted E.coli Inquiry
    Human IL4-094I Recombinant Human IL4 Protein (130 aa) E.coli Inquiry
    Rabbit IL4-1040R Recombinant Rabbit IL4 Protein, His-tagged HEK293F N-His Inquiry
    Cattle IL4-1041C Recombinant Cattle IL4 Protein, His-tagged E.coli N-His Inquiry
    Canine IL4-177C Recombinant Canine IL4 Protein E.coli Inquiry
    Human IL4-178H Recombinant Human IL4 Protein E.coli Inquiry
    Mouse IL4-179M Recombinant Mouse IL4 Protein E.coli Inquiry
    Human IL4-1801HFL Recombinant Full Length Human IL4 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Porcine IL4-180P Recombinant Porcine IL4 Protein E.coli Inquiry
    Porcine IL4-181P Recombinant Porcine IL4 Protein E.coli Inquiry
    Human IL4-203H Recombinant Active Human IL4 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Mouse Il4-204M Recombinant Active Mouse IL4 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Pig IL4-205P Recombinant Active Pig IL4 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Cattle IL4-2317C Recombinant Cattle IL4 Protein, His-tagged HEK293F N-His Inquiry
    Guinea pig Il4-2318G Recombinant Guinea pig Il4 Protein, His-tagged HEK293F N-His Inquiry
    Guinea pig Il4-2319G Recombinant Guinea pig Il4 Protein, His-tagged E.coli N-His Inquiry
    Pig IL4-242I Recombinant Pig IL4 Protein CHO Inquiry
    Mouse Il4-243I Recombinant Mouse Il4 Protein CHO Inquiry
    Human IL4-244I Recombinant Human IL4 Protein (129 aa) CHO Inquiry
    Rat Il4-245I Recombinant Rat Il4 Protein, His-tagged CHO His Inquiry
    Human IL4-25HG Recombinant Human IL4 Protein (His25-Ser153), GMP Grade, Animal-Free E.coli Inquiry
    Dog IL4-3104D Recombinant Dog IL4 protein, His-tagged E.coli His Inquiry
    Human IL4-3105H Recombinant Human IL4 protein, His-SUMO-tagged E.coli His-SUMO Inquiry
    Human IL4-36H Recombinant Human IL4 Protein, Animal Free Human cells Inquiry
    Cynomolgus monkey IL4-3701C Recombinant Cynomolgus monkey IL4 protein, His-tagged E.coli His Inquiry
    Human IL4-42H Recombinant Human IL4 Protein E.coli Inquiry
    Human IL4-5448H Recombinant Human IL4 protein, His-tagged Yeast His Inquiry
    Sheep IL4-5449S Recombinant Sheep IL4 protein, His-tagged Yeast His Inquiry
    Cynomolgus monkey IL4-5552C Recombinant Cynomolgus monkey IL4 protein, His-tagged Yeast His Inquiry
    Human IL4-5677HF Recombinant Full Length Human IL4 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human IL4-92H Recombinant Human IL4 Protein Human Cell Inquiry
    Human DMABT-H19228 Mouse Anti-IL4 Monoclonal Antibody Mouse Alexa Fluor 488 Inquiry
    Human DMABT-H19229 Rat Anti-IL4 Monoclonal Antibody Rat Alexa Fluor 488 Inquiry
    Human IL4-001H Recombinant Human IL4 Protein, His-tagged HEK293 His Inquiry
    Human IL4-1057H Recombinant Human IL4 Protein (His25-Ser153), Biotinylated E.coli N/A Inquiry
    Human IL4-112HG GMP Recombinant Human IL4 protein E.coli N/A Inquiry
    Human IL4-139H Recombinant Human IL4 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi Inquiry
    Human IL4-139HG GMP Recombinant Human IL4 Protein E. coli Inquiry
    Human IL4-139HGB GMP Recombinant Human IL4 Protein E. coli Inquiry
    Human IL4-150HG GMP Recombinant Human IL4 Protein HEK293 N/A Inquiry
    Human IL4-151HG GMP Recombinant Human IL4 protein CHO Inquiry
    Human IL4-202H Recombinant Human IL4 Protein, His-Avi-tagged HEK293 His-Avi Inquiry
    Human Il4-2099H Recombinant Human Il4 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human IL4-3924H Recombinant Human IL4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human IL4-5183H Recombinant Human IL4 Protein, GST-tagged Wheat Germ GST Inquiry
    Human IL4-93H Human Interleukin-4 (rDNA derived) Reference standard N/A Inquiry
    Mouse Il4-109M Recombinant Mouse Il4 Protein E.coli Inquiry
    Mouse Il4-110M Recombinant Mouse Il4 Protein HEK293 Inquiry
    Mouse Il4-112M Mouse Interleukin-4 (rDNA derived) Reference standard N/A Inquiry
    Mouse Il4-5181M Recombinant Mouse Il4 Protein E.coli N/A Inquiry
    Rat Il4-032RG GMP Recombinant Rat Il4 protein, His-tagged HEK293 His Inquiry
    Rat Il4-4344R Recombinant Rat Il4 Protein Yeast N/A Inquiry
    Canine IL4-921C Recombinant Canine IL4 Protein (His25-His132) E.coli N/A Inquiry
    Ovine IL4-4323O Recombinant Ovine IL4 Protein Yeast N/A Inquiry

    IL4 involved in several pathways and played different roles in them. We selected most pathways IL4 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IFNA12; IFNA2; TNFSF15; CXCR5; CXCL13; TNFSF11; OSM; BMP2; LTBR; IL20RB
    PIK-Akt signaling pathway PPP2R2C; PCK1; SGK3; COL4A1; VEGFA; PHLPP1; MDM2; COL6A4; Itga10&Itgb1; PDGFB
    Jak-STAT signaling pathway IL2RGB; EP300; PIK3CB; PIAS4; LEP; AOX3; PIK3R2; STAM; PTPN11B; IL20RB
    Hematopoietic cell lineage IL1R2; CD14; IL5; CD1E; Il4ra; EPOR; IL2RA; CD1A; ITGA1; CD38
    T cell receptor signaling pathway PPP3CA; CD40LG; MAPK1; VAV2; ICOS; CBLC; SOS1; PIK3CB; LCK; TEC
    Fc epsilon RI signaling pathway GRB2; MAPK13; PLA2G4C; PIK3CB; NRAS; MAP2K1; PIK3CD; RAF1; RAC1; GM-CSF
    Intestinal i HLA-DOA; HLA-DQB1; HLA-DPA1; IL6; IL15; BLB2; Il2; CD86; CCL25; CCR10
    ne network for IgA production HLA-DQA1; AICDA; BMA2; MHC2DCB; CXCR4A; BLB1; IL4; PIGR; CD80; HLA-DMA
    Leishmaniasis PRKCB; IL4; RELA; HLA-DQA2; MAPK11; STAT1; FCGR3A; HLA-DQB1; TGFB2; CYBA
    Measles TLR9; NFKBIB; TNFAIP3; NFKBIA; TNFRSF10C; TAB2; TNFRSF10A; IFNG; EIF2AK1; RAB9A
    Asthma IL10; MS4A2; HLA-DOA; HLA-DRB4; TNF; CCL11; EPX; HLA-DRB5; CD40LG; HLA-DQA2
    Autoi HLA-DRB5; CD40LG; PRF1; HLA-DMB; IFNA13; H2-AB1; IFNA16; Ifna11; HLA-E; CD86
    ne thyroid disease PRF1; HLA-DPA1; HLA-DQB1; HLA-DRB4; Fasl; IFNA13; HLA-DMA; Ifna15; IFNA16; CD86
    Inflammatory bowel disease (IBD) IL22; TGFB3; H2-AA; IL2RG; Il23a; Il12b; HLA-DPA1; SMAD3; MAF; IFNGR2; IL1A
    Allograft rejection HLA-DOB; Il2; HLA-C; IL12B; FAS; IFNG; HLA-DQA2; CD40; TNF; IL4

    IL4 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4 itself. We selected most functions IL4 had, and list some proteins which have the same functions with IL4. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity IFNA17; TNFSF13B; LEFTY1; Il1f6; GM13288; IFNL3; GDF9; TNFSF13; BMP2B; IL5
    growth factor activity FGF3; BMP7; KLK1B3; INHBC; Artn; IGF1; NDR2; Fgf15; FGF17; BMP15
    interleukin-4 receptor binding IL4; PIBF1
    protein binding AMPD2; C2orf57; GJD3; C17orf82; GLYR1; SALL1; C11orf68; NCKAP1L; ADAMTS10; GM5506

    IL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4.

    IL4R; IL2RG; IL13RA1

    Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
    Maruyama, S; Kanoh, M; et al. A novel function of interferon regulatory factor-1: inhibition of T(h)2 cells by down-regulating the Il4 gene during Listeria infection. INTERNATIONAL IMMUNOLOGY 27:143-152(2015).

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