|Official Full Name||Interleukin 4|
|Background||Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). The term interleukin derives from as a means of communication, and deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes. The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.|
|Synonyms||B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF1; Binetrakin; BSF-1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; IL 4; IL4_HUMAN; Il4e12; Interleukin 4, isoform 1; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MFF; MGC79402; Pitrakinra; TCGF2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
IL4 involved in several pathways and played different roles in them. We selected most pathways IL4 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||IFNA12; IFNA2; TNFSF15; CXCR5; CXCL13; TNFSF11; OSM; BMP2; LTBR; IL20RB|
|PIK-Akt signaling pathway||PPP2R2C; PCK1; SGK3; COL4A1; VEGFA; PHLPP1; MDM2; COL6A4; Itga10&Itgb1; PDGFB|
|Jak-STAT signaling pathway||IL2RGB; EP300; PIK3CB; PIAS4; LEP; AOX3; PIK3R2; STAM; PTPN11B; IL20RB|
|Hematopoietic cell lineage||IL1R2; CD14; IL5; CD1E; Il4ra; EPOR; IL2RA; CD1A; ITGA1; CD38|
|T cell receptor signaling pathway||PPP3CA; CD40LG; MAPK1; VAV2; ICOS; CBLC; SOS1; PIK3CB; LCK; TEC|
|Fc epsilon RI signaling pathway||GRB2; MAPK13; PLA2G4C; PIK3CB; NRAS; MAP2K1; PIK3CD; RAF1; RAC1; GM-CSF|
|Intestinal i||HLA-DOA; HLA-DQB1; HLA-DPA1; IL6; IL15; BLB2; Il2; CD86; CCL25; CCR10|
|ne network for IgA production||HLA-DQA1; AICDA; BMA2; MHC2DCB; CXCR4A; BLB1; IL4; PIGR; CD80; HLA-DMA|
|Leishmaniasis||PRKCB; IL4; RELA; HLA-DQA2; MAPK11; STAT1; FCGR3A; HLA-DQB1; TGFB2; CYBA|
|Measles||TLR9; NFKBIB; TNFAIP3; NFKBIA; TNFRSF10C; TAB2; TNFRSF10A; IFNG; EIF2AK1; RAB9A|
|Asthma||IL10; MS4A2; HLA-DOA; HLA-DRB4; TNF; CCL11; EPX; HLA-DRB5; CD40LG; HLA-DQA2|
|Autoi||HLA-DRB5; CD40LG; PRF1; HLA-DMB; IFNA13; H2-AB1; IFNA16; Ifna11; HLA-E; CD86|
|ne thyroid disease||PRF1; HLA-DPA1; HLA-DQB1; HLA-DRB4; Fasl; IFNA13; HLA-DMA; Ifna15; IFNA16; CD86|
|Inflammatory bowel disease (IBD)||IL22; TGFB3; H2-AA; IL2RG; Il23a; Il12b; HLA-DPA1; SMAD3; MAF; IFNGR2; IL1A|
|Allograft rejection||HLA-DOB; Il2; HLA-C; IL12B; FAS; IFNG; HLA-DQA2; CD40; TNF; IL4|
IL4 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4 itself. We selected most functions IL4 had, and list some proteins which have the same functions with IL4. You can find most of the proteins on our site.
|cytokine activity||IFNA17; TNFSF13B; LEFTY1; Il1f6; GM13288; IFNL3; GDF9; TNFSF13; BMP2B; IL5|
|growth factor activity||FGF3; BMP7; KLK1B3; INHBC; Artn; IGF1; NDR2; Fgf15; FGF17; BMP15|
|interleukin-4 receptor binding||IL4; PIBF1|
|protein binding||AMPD2; C2orf57; GJD3; C17orf82; GLYR1; SALL1; C11orf68; NCKAP1L; ADAMTS10; GM5506|
IL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4.
IL4R; IL2RG; IL13RA1
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