EGF Ligands
About EGF Ligands
EGF (epidermal growth factor) ligands are a family of small proteins that bind and activate the epidermal growth factor receptor (EGFR) on the cell surface. EGF ligands are involved in a wide range of biological processes including cell growth, development, differentiation, proliferation, migration, survival, tissue regeneration and tissue repair. They are essential for the development and maintenance of various organs and tissues such as skin, liver, kidney, and brain. EGF family members share at least one common EGF structural domain, which consists of six conserved cysteine residues forming three disulfide bonds. EGF ligand family members include EGF, neuromodulin, bilobalamin, betacellulin, etc. The EGF family members' The activity of EGF family members is mediated by the EGF R/ErbB receptor tyrosine kinase. When unregulated, members of this family and their receptors are involved in tumor formation. They are secreted or membrane-bound molecules that regulate a variety of cellular functions through the activation of intracellular signaling pathways such as the MAPK/ERK and PI3K/AKT pathways. In addition, dysregulation of EGF ligands may contribute to the progression of diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.
Available Products and Information of EGF Ligands
At Creative BioMart, we offer a comprehensive range of research tools and services to support studies related to EGF ligands, including native proteins, recombinant proteins, cell & tissue lysates, GMP proteins, and protein pre-coupled magnetic meads. The following EGF ligands are displayed, click to view all related molecules/targets and research reagents. Please feel free to contact us with any questions or requests.
Products Related to EGF ligands
We offer a wide range of EGF-related molecules/targets and research reagents, including AREG, BTC, EGF, EGFL6, EGFL7, EGFL8, EREG, HB-EGF, LRIG1, NRG2, NRG4, and TGFA. The product types include native proteins, recombinant proteins, cell & tissue lysates, GMP proteins, and protein pre-coupled magnetic meads. The product types include native proteins, recombinant proteins, cell & tissue lysates, GMP proteins, and protein pre-coupled magnetic meads. You can choose the product that is right for you based on the product type, species, source, and labeling information. For more detailed and accurate information, we suggest you refer to the product specification or contact us directly.
Technical Support and Educational Resources
We provide technical support and educational resources on pathways, protein functions, interacting proteins, related articles, and related research areas to help you understand the basics of the products, experimental techniques, and applications, which will help you to correctly use and interpret the related products, please refer to the specific product web pages for detail.
Reference:
- Singh B, Carpenter G, Coffey RJ. EGF receptor ligands: recent advances. F1000Res. 2016 Sep 8;5: F1000 Faculty Rev-2270. doi: 10.12688/f1000research.9025.1. PMID: 27635238; PMCID: PMC5017282.
