EGF

  • Official Full Name

    epidermal growth factor

  • Overview

    This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
  • Synonyms

    Beta urogastrone; EGF; EGF-HUMAN; Epidermal Growth Factor; HOMG4; OTTHUMP00000219721; OTTHUMP00000219722; Pro epidermal growth factor; URG; Urogastrone;

  • Recombinant Proteins
  • Native Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Dog
  • Feline
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rat
  • Swine
  • Zebrafish
  • Adult Male Rat Submandibular Glands
  • Barley Grain
  • CHO
  • CHO-K1
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Hordeum Vulgare
  • Human Cell
  • Male Urine
  • Mammalian Cell
  • Mammalian cells
  • Mouse Submaxillary Gland
  • Nicotiana Benthamiana
  • Rabbit
  • Rice Grain
  • S.cerevisiae
  • Wheat Germ
  • yeast
  • Yeast
  • C
  • His
  • Fc
  • Fc|His
  • His(C
  • ter)
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • Met
  • Mouse|IgG|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • SUMO
  • MBP
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EGF-556H Active Recombinant Human Epidermal Growth Factor E.coli N/A
Human EGF-08H Active Recombinant Human EGF protein Rice Grain N/A
Human EGF-470H Active Recombinant Human EGF, His-tagged Mammalian cells His
Human EGF-18H Active Recombinant Human EGF, His-tagged Barley Grain His
Human EGF-551H Active Recombinant Human EGF, HIgG1 Fc-tagged CHO Fc
Human EGF-023H Active Recombinant Human EGF Protein HEK293 N/A
Human EGF-550H Active Recombinant Human EGF, MIgG2a Fc-tagged CHO Fc
Human EGF-547H Active Recombinant Mouse Epidermal Growth Factor, HIgG1 Fc-tagged CHO Fc
Human EGF-6H Active Recombinant Human Epidermal Growth Factor yeast N/A
Human EGF-9H Active Recombinant human EGF Hordeum Vulgare N/A
Human EGF-546H Active Recombinant Mouse Epidermal Growth Factor, HIgG1 Fc-tagged, mutant CHO Fc
Human EGF-545H Active Recombinant Mouse Epidermal Growth Factor, MIgG2a Fc-tagged CHO Fc
Human EGF-23H Active Native Human EGF protein Male Urine N/A
Human EGF-01HG Active GMP Recombinant Human EGF Protein CHO-K1
Human EGF-2169H Active Recombinant Human EGF protein, His-tagged HEK293 His Asn 971 - Arg 1023
Human EGF-07H Active Recombinant Human EGF Protein, HSA Conjugated Rice Grain N/A 638 aa
Human EGF-2812H Recombinant Human EGF protein, His-tagged E.coli His Ala609~Gly751
Human EGF-2813H Recombinant Human EGF protein, His-tagged E.coli His Asn971~Arg1023
Human EGF-204H Recombinant Human EGF protein, His/S-tagged E.coli His/S
Human EGF-1549H Recombinant human EGF, Active, His-tagged Nicotiana Benthamiana His
Human EGF-3113H Recombinant Human EGF Protein, GST-tagged Wheat Germ GST
Human EGF-201H Active Recombinant Human EGF protein(Asn971-Arg1023), hFc-tagged HEK293 N-hFc Asn971-Arg1023
Human EGF-479H Recombinant Human EGF, Met E.coli Met
Human EGF-232H Recombinant Human EGF, Fc-tagged CHO Fc
Human EGF-214H Recombinant Human EGF, StrepII-tagged Human Cell Strep II 971-1023, 53 a.a.
Human EGF-12320H Recombinant Human EGF, GST-tagged E.coli GST 971-1023a.a.
Human EGF-632H Recombinant Human EGF protein Yeast N/A 51
Human EGF-166H Recombinant Human Epidermal Growth Factor 21-Leu E.coli N/A
Human EGF-020E Recombinant Human EGF protein E.coli N/A 53
Human EGF-2716HCL Recombinant Human EGF cell lysate Human Cell N/A
Human EGF-108H Recombinant Human Epidermal Growth Factor (1-52) (rDNA derived) Reference standard S.cerevisiae N/A
Human CAB11526RH Rabbit Anti-Human Epidermal Growth Factor Monoclonal Antibody Rabbit N/A
Human EGF-100HG GMP Recombinant Human EGF protein E.coli N/A 53
Human EGF-26462TH Native Human EGF N/A
Human EGF-107H Recombinant Human Epidermal Growth Factor (rDNA derived) Reference standard E.coli N/A
Human EGF-1379H Recombinant Human EGF Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EGF-6282H Recombinant Human EGF protein, Mouse IgG Fc-tagged HEK293 Mouse/IgG/Fc Asn971-Arg1023
Human EGF-333H Active Recombinant Human EGF Protein (Asn 971 - Arg 1023) E.coli N/A Asn 971 - Arg 1023
Human EGF-61H Recombinant Active Human EGF Protein, Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Asn971-Arg1023
Human EGF-830HG Active GMP Recombinant Human EGF Protein E.coli
Human EGF-74H Active Recombinant Human EGF Protein E.coli
Human EGF-407H Recombinant Human EGF Protein (Asn971-Arg1023) Yeast N/A Asn971-Arg1023
Human EGF-62H Recombinant Active Human EGF Protein, His-tagged(C-ter) E.coli His(C-ter)
Human EGF-021H Active Recombinant Human EGF Protein E.coli
Human EGF-5993H Recombinant Human EGF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EGF-138H Active Recombinant Human EGF Protein E.coli
Human EGF-832HG Active GMP Recombinant Human EGF protein HEK293
Human EGF-09H Active Recombinant Human EGF Protein E.coli
Human EGF-16H Active Recombinant Human EGF Protein, Pre-aliquoted E.coli Asn971-Arg1023, with an N-terminal Met
Human EGF-037H Recombinant Human EGF Protein E.coli 1210
Human EGF-5229H Recombinant Human EGF protein, GST-tagged E.coli GST 977-1023
Human EGF-34HG Active Recombinant Human EGF Protein (Asn971-Arg1023), GMP Grade, Animal-Free E.coli Asn971-Arg1023
Human EGF-2038H Recombinant Human EGF Protein (Asn971-Arg1023), C-His tagged Yeast C-His Asn971-Arg1023
Human EGF-27HG Recombinant Human EGF Protein, GMP Grade, Animal-Free E.coli
Human EGF-428E Active Recombinant Human EGF Protein (54 aa) E.coli 54
Human EGF-2837H Recombinant Human EGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EGF-2040H Recombinant Human EGF Protein (Met608-Gly751), N-His tagged E.coli N-His Met608-Gly751
Human EGF-2039H Recombinant Human EGF Protein (Asn971-Arg1023) Mammalian cells Tag Free Asn971-Arg1023
Human EGF-429E Active Recombinant Human EGF Protein (53 aa) E.coli 53
Human EGF-2837H-B Recombinant Human EGF Protein Pre-coupled Magnetic Beads HEK293
Human EGF-2507H Recombinant Human EGF protein(1061-1140 aa), C-His-tagged E.coli C-His 1061-1140 aa
Human EGF-2508H Recombinant Human EGF protein(981-1020 aa), C-His-tagged HEK293 C-His 981-1020 aa
Human EGF-73H Active Recombinant Human EGF Protein (Asn971-Arg1023), C-His tagged, Animal-free, Carrier-free E.coli C-His Asn971-Arg1023
Human EGF-2036H Recombinant Human EGF Protein (Ala609-Gly751), His tagged E.coli His Ala609-Gly751
Human EGF-2509H Recombinant Human EGF protein(981-1020 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 981-1020 aa
Human EGF-2037H Recombinant Human EGF Protein (Asn971-Arg1023), C-His tagged E.coli C-His Asn971-Arg1023
Human EGF-4071H Recombinant Human EGF Protein (Asn971-His1024), C-His tagged Yeast C-His Asn971-His1024
Mouse EGF-561M Active Recombinant Mouse Epidermal Growth Factor, MIgG2a Fc-tagged, mutant CHO Fc
Mouse EGF-316M Active Recombinant Mouse EGF, MIgG2a Fc-tagged CHO Fc
Mouse Egf-038E Active Recombinant Mouse Egf (977-1029aa), Met tagged E.coli N/A
Mouse Egf-557M Active Recombinant Mouse Epidermal Growth Factor E.coli N/A
Mouse Egf-631M Active Recombinant Mouse Egf E.coli Met Asn977-Arg1029
Mouse Egf-634M Active Native Mouse Egf Mouse Submaxillary Gland N/A
Mouse Egf -634M Active Native Mouse Egf protein Mouse Submaxillary Gland N/A
Mouse EGF-262M Active Recombinant Mouse EGF Protein Yeast N/A Asn977-Arg1029
Mouse Egf-01M Active GMP Recombinant Mouse Egf Protein, His-Tagged E.coli His
Mouse Egf-873M Recombinant Mouse Egf Protein, His-tagged HEK293 His
Mouse EGF-261M Recombinant Mouse Egf, None tagged Yeast Fc/His
Mouse EGF-306M Recombinant Mouse Egf, Gly & Pro tagged Human Cell Fc/His
Mouse Egf-05H Recombinant Murine Epidermal Growth Factor E.coli N/A
Mouse EGF-866M Recombinant Mouse Epidermal Growth Factor, His-tagged E.coli His
Mouse Egf-868M Active Recombinant Mouse Egf protein(Asn977-Arg1029), hFc-tagged HEK293 N-hFc Asn977-Arg1029
Mouse Egf-2814M Recombinant Mouse Egf protein, His & GST-tagged E.coli His/GST Asn977~Arg1029
Mouse EGF-973MCL Recombinant Mouse EGF cell lysate Human Cell N/A
Mouse Egf-5648M Recombinant Mouse Egf Protein (Asn977-Arg1029), C-His tagged E.coli C-His Asn977-Arg1029
Mouse Egf-052M Active Recombinant Mouse Egf Protein E.coli
Mouse Egf-053M Active Recombinant Mouse Egf Protein E.coli
Mouse Egf-054M Recombinant Mouse Egf Protein, His-tagged E.coli His
Mouse Egf-427E Active Recombinant Mouse Egf Protein (54 aa) E.coli 54
Mouse EGF-75M Active Recombinant Mouse EGF Protein E.coli
Mouse Egf-055M Recombinant Mouse Egf Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Egf-898M Recombinant Mouse Egf Protein, His&SUMO-tagged E.coli N-His&SUMO Asp362-Ala483
Mouse Egf-21M Active Recombinant Mouse Egf Protein (Asn977-Arg1029), C-His tagged, Animal-free, Carrier-free E.coli C-His Asn977-Arg1029
Mouse EGF-1410M Active Recombinant Mouse EGF protein, Fc-tagged HEK293 Fc Asn977-Arg1029
Mouse Egf-05M Recombinant Mouse Egf protein E.coli N/A 53
Mouse Egf-63M Recombinant Mouse EGF Protein, His-tagged(C-ter) HEK293 His(C-ter) Trp29-Arg1029
Mouse Egf-7197M Recombinant Mouse Egf Protein, His-tagged E.coli His 977-1029
Mouse Egf-64M Recombinant Active Mouse EGF Protein, His-tagged(C-ter) E.coli His(C-ter)
Rat Egf -636R Active Recombinant Rat Egf protein E.coli N/A 53 amino acids
Rat EGF-2026R Recombinant Rat EGF Protein Mammalian Cell His
Rat Egf-2816R Recombinant Rat Egf protein, His & GST-tagged E.coli His/GST Asn974~Arg1026 (Accession # P07522)
Rat Egf-550R Active Recombinant Rat Egf protein E.coli N/A Asn974-Arg1026
Rat Egf-460R Recombinant Rat Epidermal Growth Factor E.coli N/A
Rat Egf-636R Recombinant Rat Egf protein E.coli N/A 53
Rat EGF-76R Active Recombinant Rat EGF Protein E.coli
Rat Egf-1410R Recombinant Rat Egf Protein, His-tagged E.coli N-His Asn974-Arg1026
Rat Egf -635R Native Rat Egf protein Adult Male Rat Submandibular Glands N/A
Rat Egf-023RG Active GMP Recombinant Rat Egf protein, Fc-tagged HEK293 Fc DNA sequence encoding Rat EGF(NCBI Reference Sequence: NP_036974.) was expressed with Fc tag at the C-terminal.
Rat Egf-426E Active Recombinant Rat Egf Protein (54 aa) E.coli 54
Rat Egf-291E Active Recombinant Rat Egf Protein CHO
Rat Egf-635R Native Rat Egf Adult Male Rat Submandibular Glands N/A
Rat EGF-1683R-B Recombinant Rat EGF Protein Pre-coupled Magnetic Beads HEK293
Rat Egf-013E Active Recombinant Rat Egf Protein (54 aa) E.coli 54
Rat EGF-1683R Recombinant Rat EGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Dog EGF-2810D Recombinant Dog EGF protein, His-tagged E.coli His Asn973~Leu1201 (Accession # Q9BEA0)
Dog EGF-2809D Recombinant Dog EGF protein, His-tagged E.coli His His367~Phe489 (Accession # Q9BEA0)
Dog EGF-2811D Recombinant Dog EGF protein, His-tagged E.coli His Ala611~Gly753 (Accession # Q9BEA0)
Canine EGF-4366C Active Recombinant Canine EGF protein(Asn973-Arg1024) Yeast N/A Asn973-Arg1024
Canine EGF-362C Active Recombinant Canine EGF protein(Asn973-Arg1024), His-tagged E.coli N-His Asn973-Arg1024
Feline EGF-4411F Recombinant Feline EGF Protein Yeast N/A 52aa
Feline EGF-2215F Recombinant Feline EGF protein, hFc-tagged HEK293 hFc Asn969-Arg1020
Porcine EGF-01P GMP Recombinant Porcine EGF Protein, His-Tagged E.coli His
Swine EGF-4362S Recombinant Swine EGF Protein Yeast N/A 53aa
Zebrafish EGF-11750Z Recombinant Zebrafish EGF Mammalian Cell His
Pig EGF-2815P Recombinant Pig EGF protein, His-tagged E.coli His Ala45~His275
Pig EGF-899P Recombinant Pig EGF Protein, His-tagged HEK293F N-His Asn970-Arg1022
Pig EGF-200P Recombinant Pig EGF Protein (Asn970-Arg1022), C-His tagged, Animal-free, Carrier-free E.coli C-His Asn970-Arg1022
Pig EGF-201P Recombinant Pig EGF Protein (Asn970-Arg1022), C-His tagged, Animal-free, Carrier-free E.coli C-His Asn970-Arg1022
Pig EGF-900P Recombinant Pig EGF Protein, His-tagged E.coli N-His Asn970-His1023
Chicken EGF-1079C Recombinant Chicken EGF Mammalian Cell His
Chicken EGF-4412C Recombinant Chicken EGF Protein Yeast N/A 55aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • EGF Related Signal Pathway

EGF involved in several pathways and played different roles in them. We selected most pathways EGF participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Arf6 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationPAQR3B;NTF7;SLC14A2;JAK1;DUSP7;FRS2;AKAP9;SPTB;SPRED3
Adaptive Immune SystemUBR1;FBXO3;CD160;TREML2;SIGLEC5;KIFAP3;ACTR1A;RAPGEF4;CDKN1B
Arf6 signaling eventsIPCEF1;ADAP1;AGTR1;EFNA1;FBXO8;EGFR;ARAP2;KIF13B;ADRB2
Axon guidanceABL1;FRS3;CAP1;DPYSL5A;EGF;NTN1B;GNAI1;SEMA3B;GFRA2
Bladder cancerARAF;ERBB2;MAPK1;E2F1;MAP2K2;RAF1;CDKN2A;CDK4;E2F2
Ceramide signaling pathwayEGF;DERL3;PAWR;CRADD;CTSD
Choline metabolism in cancerRAC2;PDGFC;PDGFRA;SLC5A7;PLCG1;PIK3R3;TSC1;PRKCG;MTOR
Constitutive Signaling by Aberrant PI3K in CancerKLB;FRS2;HBEGF;NRG4;NRG3;EGF;TRAT1

EGF has several biochemical functions, for example, calcium ion binding, epidermal growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EGF itself. We selected most functions EGF had, and list some proteins which have the same functions with EGF. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCABP5A;THBS1;EFCC1;MMP19;RPH3AL;TC2N;LRP1;SYTL2;CAPN2L
epidermal growth factor receptor bindingCBLC;HBEGFB;YES1;HBEGF;LINGO1B;Fert2;RNF126;FAM83B;VAV3
growth factor activityFGF8;IL10;BMP16;IL6;IL11;FGF3;GDF15;NODAL;INHBB
protein bindingTOR1AIP2;RASSF3;SNX12;HTN1;CNIH4;KCTD14;PLEKHG2;TREX1;NPEPL1
transmembrane receptor protein tyrosine kinase activator activityEGF;EFNA5;NRG1;ANGPT4;NRG3;GREM1

EGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGF here. Most of them are supplied by our site. Hope this information will be useful for your research of EGF.

EGFR; S100A4; Egfr

Research Area

Related articles

Ganji, R; Nabiuni, M; et al. Development of Mouse Preantral Follicle after In Vitro Culture in A Medium Containing Melatonin. CELL JOURNAL 16:546-553(2015).
Chen, XH; Liu, ZC; et al. TGF-beta and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells. MOLECULAR IMMUNOLOGY 65:34-42(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is EGF protein produced in the body? 02/07/2022

The body naturally produces EGF protein, and it can also be synthesized for clinical applications using biotechnological methods.

Are there any side effects associated with the clinical use of EGF protein? 12/06/2021

Generally, EGF is well-tolerated, but localized irritation or redness at the application site can occur in some cases.

Can EGF be used in the treatment of burns? 11/03/2021

Yes, EGF has been explored for its potential in treating burns by promoting the regeneration of damaged skin tissue.

What are the primary clinical applications of EGF protein? 10/19/2021

EGF protein is widely used in clinical settings for wound healing, tissue regeneration, and certain dermatological conditions.

Is EGF used in cosmetic products, and if so, for what purpose? 09/28/2019

Yes, EGF is a common ingredient in some cosmetic products due to its ability to promote skin rejuvenation and reduce the appearance of fine lines and wrinkles.

Customer Reviews (3)

Write a review
Reviews
01/27/2020

    This can be advantageous in understanding disease mechanisms and developing novel therapeutics.

    04/12/2018

      The manufacturer can provide detailed documentation on the quality control measures undertaken during protein production and purification.

      05/09/2016

        The manufacturer can offer technical expertise and guidance to researchers regarding the proper use, handling, and storage of EGF protein.

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