tgfa Protein, transforming growth factor, alpha


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Official Full Name transforming growth factor, alpha
Background Transforming growth factors (TGFs) are potent mitogeni c polypeptides. Two classes of TGFs have been identified: TGFα and TGFβ . TGF α is synthesized as a 160 amino acid, trans membrane precursor. The precursor undergoes sequential external proteolytic cleavage, releasing TGFα species ranging in molecular weight from 6-25 kDa. Mature TGFα is an acid- and heat-stable 50 amino acid polypeptide of 5.5 kDa. It is secreted by a variety of transformed cells and tumors, and by a number of embryoni c cells as well as some normal adult tissues including the brain and skin keratinocytes. Mature TGF α is approximately 30% homologous, at the amino acid level, to epidermal growth factor (EGF). TGF α binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor, and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor-beta. Transformation of cells, in vitro, by certain viruses including SV40 and polyoma virus, as well as transformation by the activated ras oncogene can lead to increased secretion of TGF α. TGF α may play a role in tumor formation by an autocrine/paracrine mechanism whereby TGFα promotes and sustains the transformed character of the cells from which it is secreted as well as that of neighboring cells. The biological relevance of TGF α in tumor development is supported by reports that multiple molecular weight forms of TGF α may be found in the urine of cancer patients in amounts which differ from those found in normal urine samples. TGF α may also play a role in normal development including wound healing. The major difficulty impeding the investigation of the normal and pathological roles of TGFα in vivo has been the use of activity-based biological assays that do not distinguish between TGFα and other related molecules (e.g., EGF). The TGF α ELISA is highly specific and can detect less than 10 pg/ml of human TGF α in a variety of biological fluids and tissue culture media.
Synonyms TFGA; TGF-alpha; protransforming growth factor alpha
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Sheep
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • yeast
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Sheep TGFA-1538S Recombinant Sheep TGFA Protein (24-97 aa), GST-tagged Yeast GST
    Sheep TGFA-828S Recombinant Sheep TGFA Protein (24-97 aa), GST-tagged E.coli GST
    Human TGFA-1121HCL Recombinant Human TGFA 293 Cell Lysate HEK293 N/A
    Human TGFa-149H Recombinant Human TGFa E.coli N/A
    Human TGFA-29704TH Native Human TGFA E.coli N/A
    Human TGFA-3208H Recombinant Human TGFA, GST-tagged E.coli GST
    Human TGFA-386H Recombinant Human TGFA, None tagged E.coli His
    Human TGFA-522H Recombinant Human TGFA protein, His & T7-tagged E.coli His/T7
    Human TGFA-538H Recombinant Human TGFA Human N/A
    Human TGFA-5521H Recombinant Human Transforming Growth Factor, Alpha E.coli N/A
    Human TGFA-7H Recombinant Human Tumor Necrosis Factor yeast N/A
    Mouse TGFA-16701M Recombinant Mouse TGFA Protein Mammalian Cell His
    Rat Tgfa-523R Recombinant Rat Tgfa protein, His-tagged E.coli His
    Rat TGFA-6034R Recombinant Rat TGFA Protein Mammalian Cell His
    Chicken TGFA-1133C Recombinant Chicken TGFA Mammalian Cell His
    Zebrafish TGFA-7273Z Recombinant Zebrafish TGFA Mammalian Cell His

    tgfa involved in several pathways and played different roles in them. We selected most pathways tgfa participated on our site, such as ErbB signaling pathway, Pathways in cancer, Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with tgfa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway PIK3CA; GRB2B; RPS6KB1; MAP2K2B; ABL1; BAD; ELK1; CBLB; RAF1; PRKCBA
    Pathways in cancer FN1; TPR; BAD; GRB2; RBX1; FZD10; WNT5A; ARHGEF12; LAMA2; RELA
    Renal cell carcinoma AKT1; EP300; FH1; PIK3CA; ARNT; SOS1; ETS1; RAF1; VHL; TGFA
    Pancreatic cancer MAPK9; TRP53; PIK3R2; RAC2; PIK3R1; AKT1; RAD51; ERBB2; IKBKG; MAPK3
    Prostate cancer NKX3; SMARCA4; NRAS; EP300; PIK3CA; INS2; NDRG1; GRB2; PIK3CG; TCF7L2
    Non-small cell lung cancer PRKCG; RB1; GRB2; TRP53; ALK; PRKCB; TGFA; FOXO3; PLCG2; RASSF5

    tgfa has several biochemical functions, for example, epidermal growth factor receptor binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tgfa itself. We selected most functions tgfa had, and list some proteins which have the same functions with tgfa. You can find most of the proteins on our site.

    Function Related Protein
    epidermal growth factor receptor binding ARF4; ATXN2; VAV3; PLSCR1; FER; CBLC; EGF; EFEMP1; HBEGFA; HBEGF
    growth factor activity HDGFRP3; PRL2C3; FGF13A; INHBAB; BMP4; PDGFA; GPI; HGF; CSF2; IGF2A
    protein binding LRRFIP1; PIK3R3; CHIC2; PRKCZ; TBC1D10A; MECP2; HK2; MTA1; GLS2; CDC42SE2

    tgfa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tgfa here. Most of them are supplied by our site. Hope this information will be useful for your research of tgfa.

    EGFR; SGTA; Magi3; MAGI3; MAGI2; ERBB2; ADAM17; NKD2; Gorasp2

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