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Official Full Name amphiregulin
Background The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
Synonyms AREG; amphiregulin; schwannoma derived growth factor , SDGF; AR; Colorectum cell derived growth factor; CRDGF; A REG; MGC13647; Schwannoma derived growth factor; SDGF; OTTHUMP00000160473; OTTHUMP00000219184; schwannoma-derived growth factor; colorectum cell-derived growth factor; AREGB
    • Species :
    • Cattle
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AREG-134H Recombinant Human Amphiregulin HEK293 N/A
    Human AREG-516H Recombinant Human AREG protein, His & GST-tagged E.coli His/GST
    Human AREG-529H Recombinant Human AREG protein E.coli N/A
    Human AREG-7291H Recombinant Human AREG, None tagged E.coli N/A
    Human AREG-743H Recombinant Human AREG protein, GST-tagged Wheat Germ GST
    Human AREG-8762HCL Recombinant Human AREG 293 Cell Lysate HEK293 N/A
    Human AREG-918H Recombinant Human AREG Protein, GST-His-tagged E.coli GST/His
    Mouse Areg-32M Recombinant Mouse Areg protein E.coli N/A
    Rat Areg-3433R Recombinant Rat Areg, His-tagged E.Coli or Yeast His
    Rat Areg-517R Recombinant Rat Areg protein, His & T7-tagged E.coli His/T7
    Rat AREG-746R Recombinant Rat AREG Protein Mammalian Cell His
    Cattle AREG-515C Recombinant Cattle AREG protein, His & GST-tagged E.coli His/GST

    areg involved in several pathways and played different roles in them. We selected most pathways areg participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with areg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Asparagine N-linked glycosylation LMAN2; GNE; TRAPPC6BL; TRAPPC3; TRAPPC4; MPDU1; OS9; DPAGT1; MLEC; STT3A
    COPII (Coat Protein 2) Mediated Vesicle Transport ANKRD28; TRAPPC3; CNIH; GOLGA2; TFG; SEC16B; TRAPPC6BL; SCFD1; CSNK1D; TRAPPC10
    Cargo concentration in the ER SEC24A; LMAN2L; CTSZ; CNIH3; SERPINA1L; SEC23A; CTSC; TMED10; CNIH2; LMAN2
    ER to Golgi Anterograde Transport USO1; CNIH2; TRAPPC2; SEC16B; TRAPPC6A; AREG; TRAPPC6BL; CTAGE5; NAPAB; SEC22A
    ErbB receptor signaling network AREG
    ErbB signaling pathway ERBB2; PIK3CB; AKT1; CBL; ERBB3B; CAMK2G; MAP2K1; PRKCBA; RAF1B; ERBB3
    FSH signaling pathway CGA; CYP19A1; AREG
    Hippo signaling pathway BMP6; SCRIB; BTRC; GLI2; FZD6; LATS2; RASSF1; BIRC2; MOBKL1A; YWHAZ

    areg has several biochemical functions, for example, cytokine activity, epidermal growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by areg itself. We selected most functions areg had, and list some proteins which have the same functions with areg. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity LEFTY2; GM13279; CMTM2; Ccl9; Il23a; Il12b; Ctf2; CTF1; ILTIFB; EDN1; BMP10
    epidermal growth factor receptor binding EFEMP1; LINGO1; LINGO1B; EPGN; YES1; VAV2; MS4A1; VAV3; EGF; FER
    growth factor activity VEGFA; NGF; NENF; NOV; FGF20A; CLEC11A; GMFG; FGF14; NRG1; EFEMP1
    protein binding SIRT7; RAD51; SNCG; PPP4C; TMPRSS2; MET; HIST3H3; GLYAT; TACR2; WASH1

    areg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with areg here. Most of them are supplied by our site. Hope this information will be useful for your research of areg.

    S100A4; S100A2; S100A5; CCND3; ptsA; UBQLN4

    Razis, E; Pentheroudakis, G; et al. EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 140:737-748(2014).
    Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).

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