|Official Full Name||amphiregulin|
|Background||The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.|
|Synonyms||AREG; amphiregulin; schwannoma derived growth factor , SDGF; AR; Colorectum cell derived growth factor; CRDGF; A REG; MGC13647; Schwannoma derived growth factor; SDGF; OTTHUMP00000160473; OTTHUMP00000219184; schwannoma-derived growth factor; colorectum cell-derived growth factor; AREGB|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
areg involved in several pathways and played different roles in them. We selected most pathways areg participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with areg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Asparagine N-linked glycosylation||LMAN2; GNE; TRAPPC6BL; TRAPPC3; TRAPPC4; MPDU1; OS9; DPAGT1; MLEC; STT3A|
|COPII (Coat Protein 2) Mediated Vesicle Transport||ANKRD28; TRAPPC3; CNIH; GOLGA2; TFG; SEC16B; TRAPPC6BL; SCFD1; CSNK1D; TRAPPC10|
|Cargo concentration in the ER||SEC24A; LMAN2L; CTSZ; CNIH3; SERPINA1L; SEC23A; CTSC; TMED10; CNIH2; LMAN2|
|ER to Golgi Anterograde Transport||USO1; CNIH2; TRAPPC2; SEC16B; TRAPPC6A; AREG; TRAPPC6BL; CTAGE5; NAPAB; SEC22A|
|ErbB receptor signaling network||AREG|
|ErbB signaling pathway||ERBB2; PIK3CB; AKT1; CBL; ERBB3B; CAMK2G; MAP2K1; PRKCBA; RAF1B; ERBB3|
|FSH signaling pathway||CGA; CYP19A1; AREG|
|Hippo signaling pathway||BMP6; SCRIB; BTRC; GLI2; FZD6; LATS2; RASSF1; BIRC2; MOBKL1A; YWHAZ|
areg has several biochemical functions, for example, cytokine activity, epidermal growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by areg itself. We selected most functions areg had, and list some proteins which have the same functions with areg. You can find most of the proteins on our site.
|cytokine activity||LEFTY2; GM13279; CMTM2; Ccl9; Il23a; Il12b; Ctf2; CTF1; ILTIFB; EDN1; BMP10|
|epidermal growth factor receptor binding||EFEMP1; LINGO1; LINGO1B; EPGN; YES1; VAV2; MS4A1; VAV3; EGF; FER|
|growth factor activity||VEGFA; NGF; NENF; NOV; FGF20A; CLEC11A; GMFG; FGF14; NRG1; EFEMP1|
|protein binding||SIRT7; RAD51; SNCG; PPP4C; TMPRSS2; MET; HIST3H3; GLYAT; TACR2; WASH1|
areg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with areg here. Most of them are supplied by our site. Hope this information will be useful for your research of areg.
S100A4; S100A2; S100A5; CCND3; ptsA; UBQLN4