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AREG

  • Official Full Name

    amphiregulin

  • Overview

    The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
  • Synonyms

    AREG; amphiregulin; schwannoma derived growth factor , SDGF; AR; Colorectum cell derived growth factor; CRDGF; A REG; MGC13647; Schwannoma derived growth factor; SDGF; OTTHUMP00000160473; OTTHUMP00000219184; schwannoma-derived growth factor; colorectum cell-derived growth factor; AREGB;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E. coli
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AREG-134H Active Recombinant Human Amphiregulin HEK293 N/A
Human AREG-516H Recombinant Human AREG protein, His & GST-tagged E.coli His/GST Ser20~Asp100
Human AREG-529H Recombinant Human AREG protein E.coli N/A 98
Human AREG-918H Recombinant Human AREG Protein, GST-His-tagged E.coli GST/His
Human AREG-7291H Recombinant Human AREG, None tagged E.coli N/A
Human AREG-743H Recombinant Human AREG protein, GST-tagged Wheat Germ GST
Human AREG-8762HCL Recombinant Human AREG 293 Cell Lysate HEK293 N/A
Human AREG-002H Active Recombinant Human AREG Protein E. coli
Human AREG-1163HF Recombinant Full Length Human AREG Protein, GST-tagged In Vitro Cell Free System GST 252 amino acids
Human AREG-1221H Recombinant Human AREG protein, GST-tagged E.coli GST 25-252 aa
Human AREG-02H Active Recombinant Human AREG Protein E.coli
Human AREG-195A Active Recombinant Human AREG Protein HEK293
Human AREG-0293H Recombinant Human AREG Protein (Ser101-Lys187), N-His-tagged E.coli N-His Ser101-Lys187
Mouse Areg-32M Active Recombinant Mouse Areg protein E.coli N/A
Mouse Areg-242M Recombinant Mouse Areg Protein, His-tagged E.coli N-His Ser94-Lys191
Rat AREG-746R Recombinant Rat AREG Protein Mammalian Cell His
Rat Areg-3433R Recombinant Rat Areg, His-tagged E.Coli or Yeast His 243
Rat Areg-517R Recombinant Rat Areg protein, His & T7-tagged E.coli His/T7 Val97~Ala243 (Accession # P24338)
Rat AREG-402R Recombinant Rat AREG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AREG-402R-B Recombinant Rat AREG Protein Pre-coupled Magnetic Beads HEK293
Cattle AREG-515C Recombinant Cattle AREG protein, His & GST-tagged E.coli His/GST Leu27~Ala247
Homo sapiens (Human) RFL-33712HF Recombinant Full Length Human Amphiregulin(Areg) Protein, His-Tagged E.coli expression system His Full Length (101-184)
Mus musculus (Mouse) RFL-15364MF Recombinant Full Length Mouse Amphiregulin(Areg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (100-248)
Rattus norvegicus (Rat) RFL-9669RF Recombinant Full Length Rat Amphiregulin(Areg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (97-243)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AREG Related Articles
  • AREG Related Research Area

AREG involved in several pathways and played different roles in them. We selected most pathways AREG participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with AREG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationST6GALNAC2;TMED10;CTAGE5;ST8SIA3;CNIH;DAD1;NANP;TRAPPC2L;TRAPPC6BL
COPII (Coat Protein 2) Mediated Vesicle TransportLMAN2;CTSZ;NSFB;SEC23A;TRAPPC5;BET1;TRAPPC9;NAPAB;MCFD2
Cargo concentration in the ERCNIH3;PREB;LMAN2;AREG;CTSZ;SEC24A;CTAGE5;CTSC;TMED10
ER to Golgi Anterograde TransportMIA3;PPP6R3;MCFD2;CNIH2;SERPINA1L;NAPAA;GOLGA2;SEC24A;TMED10
ErbB receptor signaling network
ErbB signaling pathwayTGFA;PTK2;PRKCB;RAF1A;PAK2;HBEGFA;GSK3B;CBLB;PIK3R5
FSH signaling pathwayCYP19A1;AREG;CGA
Hippo signaling pathwaySMAD7;PPP2R2B;ID2;BBC3;BMP4;RASSF1;PPP1CC;TCF7L2;PRKCZ

AREG has several biochemical functions, for example, cytokine activity, epidermal growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AREG itself. We selected most functions AREG had, and list some proteins which have the same functions with AREG. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIL17D;CSF1;INHBC;BMP7;IL10;Ifna15;Il1f8;KITLG;CCL4
epidermal growth factor receptor bindingRNF126;CBLC;BTC;MS4A1;SNX2;SNX4;AREG;FAM83B;EFEMP1
growth factor activityNRG3;FGF6B;INHBA;FGF17;BMP8B;AMELX;F2;BMP16;GDF1
protein bindingLIMD2;CRB3;TFR2;ZFP423;MYO5B;Icosl;TOMM70A;PLEKHA1;BAI3

AREG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AREG here. Most of them are supplied by our site. Hope this information will be useful for your research of AREG.

S100A4; S100A2; S100A5; CCND3; ptsA; UBQLN4

Razis, E; Pentheroudakis, G; et al. EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 140:737-748(2014).
Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).
  • Q&As
  • Reviews

Q&As (34)

Ask a question
Does AREG play a role in inflammatory diseases? 02/18/2023

Yes, AREG is implicated in various inflammatory diseases, such as asthma and inflammatory bowel disease, where it can modulate immune responses and contribute to tissue inflammation.

How is the AREG protein released from cells? 10/16/2022

AREG can be released from cells through multiple mechanisms, such as proteolytic cleavage by metalloproteases, exocytosis, and shedding of its precursor form.

Are there any diseases associated with dysregulation of AREG? 08/25/2022

Yes, dysregulation of AREG has been linked to various diseases, including cancer, inflammatory disorders, and certain gastrointestinal conditions.

How does AREG contribute to wound healing? 07/23/2022

AREG plays a critical role in wound healing by promoting cell migration, proliferation, and tissue regeneration, particularly in epithelial tissues.

Can AREG be used as a therapeutic target in cancer treatment? 12/22/2021

AREG has been identified as a potential therapeutic target in cancer treatment due to its involvement in promoting cancer cell growth and survival. However, further research is needed to explore its clinical utility.

What are the effects of AREG on cancer cell proliferation? 08/12/2021

AREG can promote cancer cell proliferation by binding to the EGFR and activating downstream signaling pathways that drive cell cycle progression and survival.

Is AREG involved in angiogenesis? 05/26/2021

Yes, AREG has been shown to promote angiogenesis, the formation of new blood vessels, by stimulating endothelial cell proliferation and migration.

Does AREG have any role in neurodegenerative diseases? 03/03/2021

There is limited research suggesting that AREG may have a role in neurodegenerative diseases. Some studies have shown altered AREG expression in conditions like Alzheimer's disease and Parkinson's disease, but more research is needed to fully understand its significance in these diseases.

Are there any side effects associated with blocking AREG signaling? 02/10/2021

Blocking AREG signaling may lead to potential side effects, as AREG is involved in various physiological processes. However, the specific side effects would depend on the context and the therapeutic approach used.

Are there any AREG-targeted therapies currently available? 12/27/2020

Currently, there are no approved therapies specifically targeting AREG, but there are ongoing clinical trials investigating the efficacy of targeting AREG and its associated pathways in different diseases.

Are there any ongoing clinical trials targeting AREG? 12/19/2020

There are ongoing clinical trials investigating the potential use of inhibitors and antibodies targeting AREG in cancer treatment. These trials aim to evaluate the safety and efficacy of AREG-targeted therapies alone or in combination with other treatments.

Does AREG have any role in the nervous system? 08/01/2020

Yes, AREG is implicated in various neurological processes, including neuroprotection, neural development, and synaptic plasticity.

Can AREG be produced by other cell types besides cancer cells? 07/24/2020

Yes, AREG can be produced by various cell types, including epithelial cells, fibroblasts, immune cells, and endothelial cells. Its production can be stimulated by different factors depending on the cell type and the physiological context.

How is AREG involved in mammary gland development and lactation? 01/26/2020

AREG plays a crucial role in mammary gland development and lactation by promoting the growth and differentiation of mammary epithelial cells, as well as stimulating milk production.

Is the expression of AREG protein influenced by hormones? 01/10/2020

Yes, the expression of AREG can be regulated by hormones, such as estrogens and progesterone, in various target tissues.

Can AREG be used as a biomarker for any diseases? 09/23/2019

AREG expression levels have been investigated as potential biomarkers for certain cancers, including colorectal, breast, and ovarian cancer, as well as inflammatory bowel disease.

Does AREG have any effects on cell differentiation? 09/23/2019

Yes, AREG can influence cell differentiation in certain contexts. It has been shown to promote the differentiation of various cell types, including mammary epithelial cells, neuronal progenitor cells, and keratinocytes.

Is there any evidence of AREG being involved in metastasis? 08/22/2019

There is evidence suggesting that AREG can promote metastasis in certain types of cancer. It may contribute to the invasive and migratory properties of cancer cells, aiding their spread to distant organs.

How is the AREG protein activated? 05/29/2019

The AREG protein can be activated by various signals, including growth factors, cytokines, and cell-cell interactions.

Is there any research on AREG protein in other fields apart from cancer? 02/19/2019

Yes, AREG protein research is also emerging in fields such as reproductive biology, neurological disorders, and skin diseases.

Does AREG have any role in immune response modulation? 01/31/2019

Yes, AREG has immunomodulatory properties and can influence immune cell functions, such as regulating T cell differentiation and function, and influencing the balance between immune activation and tolerance.

Can AREG protein be used as a therapeutic target? 01/16/2019

Yes, targeting AREG and its signaling pathways has shown promise in developing potential therapeutic interventions against cancer and other diseases.

Can AREG be used in targeted therapy? 12/07/2018

AREG has the potential to be used in targeted therapy, especially in cancers where AREG signaling is implicated in promoting tumor growth and survival. Targeting AREG or its signaling pathways could potentially be used in combination with other therapies to improve treatment outcomes.

Are there any inhibitors or antibodies targeting AREG? 06/28/2018

Yes, there are experimental inhibitors and anti-AREG antibodies being studied for their potential as therapeutic agents in various diseases, including cancer.

Is AREG involved in wound healing? 03/06/2018

Yes, AREG has been shown to play a role in wound healing. It stimulates the migration and proliferation of cells involved in the wound healing process, such as fibroblasts and endothelial cells, promoting tissue repair.

Can AREG be used as a diagnostic marker for cancer? 01/24/2018

AREG expression levels have been evaluated as potential diagnostic markers for certain types of cancer, including colorectal and breast cancer, to predict prognosis and guide treatment decisions.

What other cellular processes are regulated by AREG? 12/12/2017

In addition to its involvement in cellular proliferation, tissue development, and immune responses, AREG also influences processes such as cell migration, apoptosis, and stem cell maintenance.

Has the AREG gene been linked to any genetic disorders? 09/27/2017

There is limited evidence suggesting that genetic variations in the AREG gene may be associated with an increased risk of certain disorders, such as inflammatory diseases and certain types of cancers. However, more research is needed to fully understand the genetic implications of AREG.

Can AREG be used in regenerative medicine? 03/24/2017

AREG has shown promise in regenerative medicine due to its ability to stimulate tissue regeneration and repair. Further research is needed to fully understand its potential in this field.

Is AREG protein involved in normal physiological processes? 03/05/2017

Yes, AREG protein is involved in normal physiological processes such as tissue development, wound healing, and immune response regulation.

Can AREG be used as a prognostic marker for cancer? 01/26/2017

AREG expression levels have been evaluated as potential prognostic markers in several types of cancer. High AREG expression has been associated with poorer outcomes in some cases. However, further studies are needed to validate its clinical utility as a prognostic marker.

Are there any genetic mutations associated with AREG protein? 09/10/2016

Yes, certain genetic mutations in the AREG gene have been identified and linked to specific disorders, including colorectal cancer and asthma.

What are the downstream signaling pathways activated by AREG? 03/06/2016

AREG can activate various signaling pathways, including the EGFR (epidermal growth factor receptor) pathway, MAPK (mitogen-activated protein kinase) pathway, and PI3K (phosphoinositide 3-kinase)/Akt pathway.

Are there any inhibitors or antibodies targeting AREG currently in development? 02/24/2016

There are ongoing efforts to develop inhibitors and antibodies targeting AREG for various therapeutic purposes, including cancer treatment. Some preclinical and early-stage clinical trials have been conducted, but more research is needed before these agents can be widely used in clinical practice.

Customer Reviews (8)

Write a review
Reviews
08/17/2022

    The high-quality AREG protein available from reliable manufacturers ensures accurate detection and quantification of ANO4 protein levels in samples, providing valuable insights into its biological roles and signaling pathways.

    10/26/2020

      In WB experiments, AREG protein exhibits exceptional performance, making it an ideal tool for studying ANO4 protein expression, regulation, and potential functional changes.

      09/04/2020

        AREG protein demonstrates great utility in protein electron microscopy structure analysis.

        11/05/2019

          Its remarkable specificity and functionality have allowed me to investigate various cellular processes with precision and confidence.

          03/02/2019

            the manufacturer's support has been instrumental in assisting me throughout my work with the AREG protein.

            01/18/2018

              Its exceptional quality ensures accurate data and supports the validity of my research findings.

              05/22/2017

                the high-quality AREG protein is available in various forms, including recombinant proteins and purified samples, enabling researchers to select the most suitable format for their specific experimental setup.

                03/05/2017

                  The technical team's expertise and promptness in addressing any queries or concerns have been extraordinary.

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