What is ICAM1 Protein?

ICAM1 (Intercellular Adhesion Molecule 1) protein is an integral membrane protein that plays a pivotal role in the mediation of cellular adhesion, serving as a critical component in the body's immune response system. It contributes significantly to various biological mechanisms, including inflammation, cell signaling, and disease pathophysiology, making it a primary focus area in biomedical research.

Background and Discovery of ICAM1 Protein

The study of ICAM1 protein can be traced back to the 1980s, when researchers delved into the mechanisms of inflammation. ICAM1 was identified as a ligand for lymphocyte function-associated antigen 1 (LFA-1), a critical finding that established its role in cell adhesion and immune response. The gene that codes for ICAM1 protein, hitherto referred to as the ICAM1 gene, is located on chromosome 19 at locus 19p13.2.

What Is The Structure of ICAM1 Protein?

The structure of ICAM1 protein is shaped by numerous factors. Revealed through X-ray crystallography, the protein has five immunoglobulin-like domains, each consisting of about 90 to 100 amino acids. This multidomain structure allows ICAM1 to interact with varied cell types, such as leukocytes and endothelial cells, enhancing its versatility in biological function.

What Is The Function of ICAM1 Protein?

ICAM1 protein serves as majorly a cell adhesion molecule. Tightly bound to cell membranes, it facilitates leukocyte endothelial transmigration, a vital step in immune response activation. This allows leukocytes to exit the bloodstream and enter tissues where they find and destroy pathogens. Moreover, ICAM1 supports the maturation and migration of immune cells, including T cells and B cells, critical for an effective immune response.

ICAM1's role extends beyond just cell adhesion; it also contributes to signal transduction. Scientists have found a connection between ICAM1 and several signal pathways, such as the nuclear factor-kappa B (NF-κB) pathway. ICAM1 activates this pathway, which then influences the transcription of various genes linked to immune and inflammatory responses.

ICAM1 protein related diseases

Given its significant role in immune response activation and regulation, variations or dysfunctions in ICAM1 protein can lead to various diseases. For example, increased expression of ICAM1 is associated with numerous inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Furthermore, ICAM1's overexpression has also been linked to cancer progression. ICAM1 assists in the adhesion and migration of cancer cells, promoting metastasis and tumor growth.

Pertinently, ICAM1 continues to unfold as a productive research avenue due to its involvement in disease pathophysiology. ICAM1 targeted therapies are being considered for numerous inflammatory diseases and cancers due to their potential to inhibit cell adhesion and migration. For instance, an experimental antibody drug conjugate aims to target ICAM1 protein in cancer treatment. This epitomizes the potential utility of ICAM1 protein in developing targeted therapies.

Additionally, known for its role in cell adhesion and inflammation, ICAM1 protein has been utilized for engineering artificial human tissues. Researchers have also begun to explore the potential use of ICAM1 in diagnostic applications. Blood serum levels of soluble ICAM1 (sICAM1), a circulating form of ICAM1, have been considered as biomarkers for several inflammatory diseases.

In conclusion, ICAM1 protein, since its discovery, has emerged as a crucial component in understanding and controlling diverse biological mechanisms, particularly related to the immune response system and inflammatory diseases. The structure, function, associated signaling pathways, and disease implications of ICAM1 protein make it a substantial point of interest in biomedical research and applications. Continuing explorations and advances in these areas have the potential to influence the development of new therapeutic strategies and diagnostics that could revolutionize our approach to managing and treating a range of diseases.

Our Featured Products

Cat.No.	Product Name	Species	Source (Host)	Tag
ICAM1-2249H	Active Recombinant Human ICAM1 protein, His-tagged	Human	HEK293	His
ICAM1	Active Recombinant Human ICAM1 protein, Fc/Avi-tagged, Biotinylated	Human	HEK293 cells	Fc/Avi
ICAM1-2777H	Recombinant Human ICAM1 protein, GST-tagged	Human	E.coli	GST
ICAM1-657H	Recombinant Human ICAM1, None tagged	Human	Human Cell	N/A
ICAM1-656H	Recombinant Human ICAM1, Fc-His tagged	Human	Human Cell	Fc/His
ICAM1-14H	Active Recombinant Human ICAM1 Protein (28-480aa), C-hIgG-His-tagged	Human	Insect Cell	C-hIgG-His
Icam1-3323M	Recombinant Mouse Icam1, Fc-His tagged	Mouse	Human Cell	Fc/His
Icam1-2293M	Recombinant Mouse Icam1, His tagged	Mouse	Human Cell	His
Icam1-4322M	Recombinant Mouse Icam1 Protein	Mouse	Yeast	N/A
Icam1-4086R	Recombinant Rat Icam1, His tagged	Rat	Human Cell	His
ICAM1-1795R	Recombinant Rhesus Monkey ICAM1 Protein	Rhesus monkey	HEK293	N/A
ICAM1-4320B	Recombinant Bovine ICAM1 Protein	Bovine	Yeast	N/A