ABCC6

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ABCC6

Official Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.
Synonyms ABCC6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ARA, pseudoxanthoma elasticum , PXE; URG7 protein; multidrug resistance-associated protein 6; EST349056; MLP1; MRP6; URG7; MOAT-E; ATP-binding cassette sub-family C member 6; multi-specific organic anion transporter E; anthracycline resistance-associated protein; ARA; PXE; PXE1; ABC34; GACI2; MOATE
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABCC6-633H Recombinant Human ABCC6 Protein, His-tagged E.coli His
    Human ABCC6-051H Recombinant Human ABCC6 Protein, GST-Tagged Wheat Germ GST
    Human ABCC6-052H Recombinant Human ABCC6 Protein, GST-Tagged Wheat Germ GST
    Human ABCC6-29035TH Recombinant Human ABCC6 Wheat Germ N/A
    Human ABCC6-632H Recombinant Human ABCC6 Mammalian Cell His
    Human ABCC6-6HCL Recombinant Human ABCC6 cell lysate N/A
    Human ABCC6-9219H Recombinant Human ABCC, His-tagged E.coli His
    Mouse ABCC6-1104M Recombinant Mouse ABCC6 Protein Mammalian Cell His
    Mouse Abcc6-8120M Recombinant Mouse Abcc6 protein, His & T7-tagged E.coli His/T7
    Rat ABCC6-407R Recombinant Rat ABCC6 Protein Mammalian Cell His
    Rat Abcc6-8121R Recombinant Rat Abcc6 protein, His & T7-tagged E.coli His/T7
    Chicken ABCC6-4541C Recombinant Chicken ABCC6 Mammalian Cell His

    ABCC6 involved in several pathways and played different roles in them. We selected most pathways ABCC6 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCB7; ABCB5; ABCG2A; ABCD1; ABCA4; ABCB3L1; ABCB4; ABCA6; ABCC10; ABCB1A

    ABCC6 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC6 itself. We selected most functions ABCC6 had, and list some proteins which have the same functions with ABCC6. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SPG7; ORC4; SRPK3; ATP2B3A; CDK18; SRPK1A; DYRK1A; CLK2B; MAST4; DDX41
    ATPase activity, coupled to transmembrane movement of substances ABCC3; ABCD2; IPO8; ABCA4; ABCG3; TAP1; ABCG8; ABCA9; ABCC6; ABCD1
    transporter activity STEAP2; TMEM184B; NUP153; ATP6AP1; DYF-1; SLC6A20B; SLCO1F2; ABCA5; SLC23A3; HIAT1A

    ABCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC6.

    A1BG; FURIN; NR4A1; AK2; CRYL1

    Kirsch, AH; Smaczny, N; et al. Regulatory T Cells Improve Nephrocalcinosis but Not Dystrophic Cardiac Calcinosis in DBA/2 Mice. AMERICAN JOURNAL OF PATHOLOGY 183:382-390(2013).
    Pomozi, V; Le Saux, O; et al. ABCC6 Is a Basolateral Plasma Membrane Protein. CIRCULATION RESEARCH 112:E148-+(2013).

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