ABCG4
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Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 4
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Synonyms
ABCG4;ATP-binding cassette, sub-family G (WHITE), member 4;13884;ENSG00000172350;WHITE2;11q23.3;ATP-binding cassette sub-family G member 4;ATP-binding cassette sub-family G member 4;putative ABC transporter;ATP-binding cassette, subfamily G, member 4;
- Recombinant Proteins
- Arabidopsis thaliana (Mouse-ear cress)
- Dictyostelium discoideum (Slime mold)
- Homo sapiens (Human)
- Human
- E.coli
- E.coli expression system
- In Vitro Cell Free System
- Wheat Germ
- GST
- His
- His|T7
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ABCG4-8153H | Recombinant Human ABCG4 protein, His & T7-tagged | E.coli | His/T7 | Val59~Thr301 (Accession # Q9H172) |
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| Human | ABCG4-068H | Recombinant Human ABCG4 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | ABCG4-0071H | Recombinant Human ABCG4 Protein (Val59-Thr301), N-His-tagged | E.coli | N-His | Val59-Thr301 |
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| Human | ABCG4-797HF | Recombinant Full Length Human ABCG4 Protein, GST-tagged | In Vitro Cell Free System | GST | 646 amino acids |
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| Arabidopsis thaliana (Mouse-ear cress) | RFL13555AF | Recombinant Full Length Arabidopsis Thaliana Abc Transporter G Family Member 4(Abcg4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-577) |
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| Dictyostelium discoideum (Slime mold) | RFL15313DF | Recombinant Full Length Dictyostelium Discoideum Abc Transporter G Family Member 4(Abcg4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-798) |
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| Homo sapiens (Human) | RFL9437HF | Recombinant Full Length Human Atp-Binding Cassette Sub-Family G Member 4(Abcg4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-646) |
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ABCG4 involved in several pathways and played different roles in them. We selected most pathways ABCG4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ABCG4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG4 itself. We selected most functions ABCG4 had, and list some proteins which have the same functions with ABCG4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
ABCG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG4.
- Q&As
- Reviews
Q&As (21)
Ask a questionABCG4 expression was regulated redox-dependently by intracellular glutathione (GSH) levels
ABCG4 has been implicated in neurodegenerative diseases, including Alzheimer's disease. It is thought to be involved in the efflux of lipids and cholesterol from brain cells, contributing to lipid homeostasis and potentially influencing the pathogenesis of these diseases.
The heterodimerization of ABCG1 and ABCG4 indicates their ability to interact and form complexes. This interaction might be essential for their proper function or regulation.
Doxorubicin (Dox)‐induced ABCG4 upregulation causes prostate cancer (PCa) chemoresistance
The exact substrates of ABCG4 in the context of drug resistance are still being investigated. While ABCG4's involvement in mediating drug resistance has been established, the specific drugs or compounds that it transports have not been conclusively identified.
Glutathione levels dictate ABCG4 expression in androgen‐independent PCa cells.
The specific genetic or epigenetic factors influencing ABCG4-mediated drug resistance have not been extensively studied. However, it is possible that genetic variations or alterations in epigenetic marks could impact ABCG4 expression or function, potentially contributing to drug resistance.
Strategies such as targeted therapies or combination treatments may be investigated to inhibit ABCG4 expression or activity, with the aim of overcoming drug resistance and improving treatment outcomes.
Statins sensitize androgen‐independent PCa cells to Dox by inhibiting ABCG4 levels.
In the present study, we documented that doxorubicin (Dox) or cisplatin‐induced prostate cancer (PCa) chemoresistance is predominantly mediated by the induction of ABCG4 in androgen‐independent PCa cells.
The regulation of ABCG4 expression in NSCLC is not fully understood. However, studies suggest that various factors, including transcriptional regulators, signaling pathways, and microenvironmental cues, can influence ABCG4 expression.
The presence of genetic variants or mutations in ABCG4 has not been extensively studied for disease susceptibility. However, it is possible that variations in the ABCG4 gene sequence could affect its function or expression, potentially influencing disease susceptibility.
ABCG4-mediated drug resistance may involve the efflux of specific drugs or a broader range of compounds. The substrate specificity of ABCG4 is still being elucidated, and it is possible that it can transport multiple drugs or compounds.
Targeting ABCG4 is being explored as a potential strategy to overcome drug resistance in NSCLC. By inhibiting or modulating ABCG4 activity, it may be possible to prevent drug efflux and enhance the effectiveness of chemotherapy.
The specific mechanisms by which ABCG4 contributes to drug resistance in NSCLC are not yet fully understood. However, it is hypothesized that ABCG4 actively transports drugs out of cancer cells, preventing their accumulation and reducing their cytotoxic effects.
The sequence similarity of 69% between ABCG1 and ABCG4 suggests a close evolutionary relationship and potential functional similarities. This similarity may indicate shared structural and functional features that enable them to perform similar roles in cellular processes.
The regulation of ABCG4 expression and activity in the context of drug resistance is not yet fully understood. It is likely that various factors, such as genetic and epigenetic mechanisms, signaling pathways, and microenvironmental cues, influence ABCG4 expression and activity.
ABCG4 has been implicated in mediating drug resistance in non-small-cell lung cancer (NSCLC). It is likely that ABCG4 functions as an efflux transporter, pumping out anti-cancer drugs from cancer cells and reducing their effectiveness. This can contribute to treatment resistance and hinder the success of chemotherapy.
ABCG4 is regulated via NF‐kB‐c‐Myc‐cAMP‐regulatory element‐binding protein axis in androgen‐independent PCa cells.
ABCG4 play a role in Dox-mediated chemoresistance, and as a potential therapeutic target in drug-induced PCa
ABCG4 plays a role in cellular cholesterol homeostasis by facilitating the efflux of cholesterol from cells. Its expression levels can affect the balance between cholesterol influx and efflux, thereby influencing cellular cholesterol levels and lipid metabolism.
Customer Reviews (5)
Write a reviewThe availability of online resources, including FAQs and troubleshooting guides, proved helpful when encountering any challenges during my research.
he protein product maintained its activity over an extended period, allowing for long-term experiments without compromising performance
I conducted a side-by-side comparison with other protein products, and the superior quality of this product was evident in terms of purity and functionality
The company provided technical datasheets, protocols, and application notes.
The protein product underwent stringent quality control tests, ensuring the absence of endotoxins and other contaminants that could affect my assays
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