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  • Official Full Name
  • angiotensin I converting enzyme
  • Background
  • This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
  • Synonyms
  • ACE; angiotensin I converting enzyme; DCP; ICH; ACE1; DCP1; CD143; MVCD3; angiotensin-converting enzyme; kininase II; peptidase P; CD143 antigen; testicular ECA; carboxycathepsin; dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase I; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript;
Cat.#:ACE-155HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ACE Protein, GST-Tagged
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Cat.#:ACE-509HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACE protein, His & GST-tagged
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Cat.#:ACE-510HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACE protein, His-tagged
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Cat.#:ACE-744HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ACE, His-tagged
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Cat.#:ACE-8304HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ACE
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Cat.#:Ace-511MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ace protein, His & GST-tagged
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Cat.#:Ace-512MTag:His|MBP
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ace protein, His & MBP-tagged
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Cat.#:Ace-513MTag:His|S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ace protein, His & S-tagged
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Cat.#:Ace-3458RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Ace, His-tagged
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Cat.#:ACE-449RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACE Protein
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Cat.#:ACE-1570RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ACE Protein
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Cat.#:ACE-1571RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ACE Protein, hIgG1-tagged
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Cat.#:ACE-1572RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey ACE Protein, hIgG4-tagged
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Cat.#:ACE-4022CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACE
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Cat.#:ACE-514PTag:His|GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig ACE protein, His & GST-tagged
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Cat.#:ACE-3047RTag:N/A
Source (Host):N/ASpecies:Rabbit
Product nameNative rabbit ACE
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Cat.#:ACE-9094HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ACE 293 Cell Lysate
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Cat.#:Kit-2408Tag:N/A
Source (Host):Species:
Product nameAngiotensin I Converting Enzyme (ACE1) Inhibitor Screening Kit
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Cat.#:Kit-2409Tag:N/A
Source (Host):Species:
Product nameAngiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit
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Involved Pathway

ACE involved in several pathways and played different roles in them. We selected most pathways ACE participated on our site, such as ACE Inhibitor Pathway, Chagas disease (American trypanosomiasis), Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with ACE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ACE Inhibitor Pathway
ACE; AGT; AGTR2; ATP6AP2; AGTR1; CTSG; CMA1; CYP11B2
Chagas disease (American trypanosomiasis)
PPP2CB; C1QB; CASP8; BDKRB2; TLR4; PIK3R5; PPP2R2D; MAPK9; MAPK1; MAPK8
Hypertrophic cardiomyopathy (HCM)
ITGA8; ITGA6; SGCG; CACNG6; CACNG4; ITGB8; ITGB3; CACNG3; PRKAB2; CACNB1
Metabolism of Angiotensinogen to Angiotensins
GZMH; ACE; CTSG; CMA1; CPA3; CPB1; ATP6AP2; CPB2
Metabolism of proteins
SERP1; SEMG1; DPH3; MAN1B1; GATA6; KCNA3; ARSI; TRAPPC6B; PHC1; ACE
Peptide hormone metabolism
MBOAT4; SPCS3; RAB27A; SLC30A6; SLC38A8; GZMH; CPA3; CGB7; O3far1; SLC30A8
Renin secretion
Ren1; PLCB1; PLCB3; GNAS; ACE; GNAI3; PTGER4; CLCA3; REN2; CLCA1
Renin-angiotensin system
KLK1B22; MAS1; CMA1; KLK1; PRCP; THOP1; KLK1B11; ACE; CTSA; LNPEP

Protein Function

ACE has several biochemical functions, for example, actin binding, bradykinin receptor binding, carboxypeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACE itself. We selected most functions ACE had, and list some proteins which have the same functions with ACE. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein FLII; MYO9B; MICAL2B; SPTBN1; MYO1F; ANG; ACTN3B; DST; CFL1; SHROOM2
Function bradykinin receptor binding
Related Protein AGTR1; ACE; AGTR1A
Function carboxypeptidase activity
Related Protein CPA2; AEBP1; AGBL1; CPD; ACE; NAALAD2; AGBL4; CPE; CPB1; CPM
Function chloride ion binding
Related Protein CTSC; AMY2A; ACE; SLC22A6; Amy1; NLGN4X
Function drug binding
Related Protein SLC6A4A; TLR8; MT2A; RARB; ADRB2; FABP1; SRP54A; TYMS; DAAM2; CHRNB2
Function endopeptidase activity
Related Protein HTRA3; PSMA3; KLK1B22; PSMA6A; F9; ACE; KLK1B26; ADAMTS3; CD46; PSMA7
Function exopeptidase activity
Related Protein ACE; MME; GGH
Function metallopeptidase activity
Related Protein CLCA1; CNDP2; CNDP1; ACE; ADAM10B; MEP1A.1; AGBL1; PAPPA2; ANPEPB; ADAMTS4
Function mitogen-activated protein kinase binding
Related Protein SIRT1; CDK5RAP3; MICALCL; ARRB2; NBR1; EP300; MAPKAPK2B; TNIP1; PLCB4; ABL1
Function mitogen-activated protein kinase kinase binding
Related Protein MAP3K11; TAOK2; MAPK8IP3; TRIB1; PIN1; RAF1; ACE; DLG1; TRIB2; BRAF
Function peptidyl-dipeptidase activity
Related Protein ACE; TMEM27
Function protein binding
Related Protein DSN1; COX5A; KDM5B; ARIH2; ITGB7; PPP6R2; BAG6; RIBC2; AKR7A3; TDGF1
Function tripeptidyl-peptidase activity
Related Protein ACE; TPP2; TPP1
Function zinc ion binding
Related Protein TRIM13; ZFP326; SUV39H1B; TRIM35-1; RNF26; LMX1BA; ZPR1; GATA1; TRAF7; RNF169

Interacting Protein

ACE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACE here. Most of them are supplied by our site. Hope this information will be useful for your research of ACE.
CD247

ACE Related Articles

Connolly, A; O'Keeffe, MB; et al. Generation and identification of angiotensin converting enzyme (ACE) inhibitory peptides from a brewers' spent grain protein isolate. FOOD CHEMISTRY 176:64-71(2015).
Kleekayai, T; Harnedy, PA; et al. Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes. FOOD CHEMISTRY 176:441-447(2015).