ACE
-
Official Full Name
angiotensin I converting enzyme -
Overview
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010] -
Synonyms
ACE;angiotensin I converting enzyme;DCP;ICH;ACE1;DCP1;CD143;MVCD3;angiotensin-converting enzyme;kininase II;peptidase P;CD143 antigen;testicular ECA;carboxycathepsin;dipeptidyl carboxypeptidase 1;dipeptidyl carboxypeptidase I;angiotensin converting enzyme, somatic isoform;angiotensin I converting enzyme (peptidyl-dipeptidase A) 1;angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Pig
- Rabbit
- Vibrio cholerae serotype O1
- Wheat Germ
- HEK293
- E.Coli/Yeast
- Mammalian Cells
- E.coli
- Insect Cells
- Insect cells
- NS0
- GST
- Non
- Fc
- hIgG4
- His
- MBP
- S
- Avi
- DDK
- Myc
Involved Pathway
ACE involved in several pathways and played different roles in them. We selected most pathways ACE participated on our site, such as ACE Inhibitor Pathway,Chagas disease (American trypanosomiasis),Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with ACE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | INHBAA,GNE,B3GALTL,SLC25A12,CNIH,DCP2,IGFBP6A,SLC25A13,TIMM17B,PDIA6 |
| Metabolism of Angiotensinogen to Angiotensins | ATP6AP2,CPB2,CPB1,GZMH,CTSG,CMA1,CPA3 |
| ACE Inhibitor Pathway | ATP6AP2,AGT,CTSG,AGTR1,CMA1,CYP11B2,AGTR2 |
| Renin-angiotensin system | ATP6AP2,REN,KLK1B26,AGTR1A,ENPEP,KLK1,REN2,ACE2,KLK1B9,CTSA |
| Renin secretion | PDE3A,PLCB1,CLCA1,REN,PDE1C,CALML5,PPP3R2,Ren1,CLCA2,GUCY1A3 |
| Peptide hormone metabolism | GRP,SLC38A8,INHA,MBOAT4,CPE,CPN1,SLC30A6,RAB27A,GPR119,EXOC8 |
| Chagas disease (American trypanosomiasis) | PIK3CA,CD3D,BDKRB2,PIK3CG,MAPK1,GNA15,CCL2,MAPK10,Ccl12,LOC100033925 |
| Hypertrophic cardiomyopathy (HCM) | ITGA9,CACNG8,Itga10&Itgb1,CACNG3,MYBPC3,PRKAG2,MYH7,ITGB5,ITGA4,SGCA |
Protein Function
ACE has several biochemical functions, for example, actin binding,bradykinin receptor binding,carboxypeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACE itself. We selected most functions ACE had, and list some proteins which have the same functions with ACE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mitogen-activated protein kinase kinase binding | TAOK2,ARRB1,MAP3K11,BRAF,PIN1,TRIB3,IGBP1,RAF1,DLG1,MAPK8IP3 |
| carboxypeptidase activity | NAALADL1,AGBL1,BLMH,ACE2,CNDP1,CPD,NAALAD2,AGBL4,CPM,CPB1 |
| peptidyl-dipeptidase activity | TMEM27 |
| metallopeptidase activity | ACY1,ADAM23,CLCA2,YME1L1,MMP23BB,PAPPA2,ADAMTS15A,GM5136,C6AST1,ADAMTS5 |
| drug binding | SRP54A,PIGC,ATP5O,PDXK,P2RX2,PDE4D,PPARA,CHRM1,PYGM,GLRB |
| zinc ion binding | SUV39H1B,RXRGB,GATAD2B,IRGF4,MPI,NR6A1,ADAM5P,HDAC4,DEF8,BRD1 |
| endopeptidase activity | PSMB10,PSMA4,KLK1B1,ADAM10,PSMB9,PCSK6,PSMA6,Ren1,SENP3,SENP1 |
| bradykinin receptor binding | AGTR1A,AGTR1 |
| mitogen-activated protein kinase binding | MICALCL,ATF7,CDK5RAP3,ARRB2,MAPKAPK2,MAPKAPK2A,ABL1,TNIP1,TPR,NBR1 |
Interacting Protein
ACE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACE here. Most of them are supplied by our site. Hope this information will be useful for your research of ACE.
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References
- Connolly, A; O'Keeffe, MB; et al. Generation and identification of angiotensin converting enzyme (ACE) inhibitory peptides from a brewers' spent grain protein isolate. FOOD CHEMISTRY 176:64-71(2015).
- Kleekayai, T; Harnedy, PA; et al. Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes. FOOD CHEMISTRY 176:441-447(2015).
