acss2
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  • Official Full Name
  • acyl-CoA synthetase short-chain family member 2
  • Background
  • This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • ACSS2; acyl-CoA synthetase short-chain family member 2; ACAS2, acetyl Coenzyme A synthetase 2 (ADP forming); acetyl-coenzyme A synthetase, cytoplasmic; AceCS; ACS; ACSA; dJ1161H23.1; cytoplasmic; ACAS2; Acetate CoA ligase; Acetate thiokinase; Acetate--CoA ligase; Acetyl CoA synthetase; Acetyl Coenzyme A synthetase 2 (ADP forming); Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; Acetyl-coenzyme A synthetase; ACSA_HUMAN; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; Acyl-activating enzyme; Cytoplasmic acetyl coenzyme A synthetase; MYH7B; acetate-CoA ligase; cytoplasmic acetyl-coenzyme A synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming)
Cat.#:ACSS2-1107MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse ACSS2 Protein, His-tagged
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Cat.#:ACSS2-209HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACSS2 Protein, GST-tagged
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Cat.#:ACSS2-210HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACSS2 Protein, GST-tagged
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Cat.#:ACSS2-1236MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACSS2 Protein
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Cat.#:ACSS2-219RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACSS2 Protein, His-tagged
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Cat.#:ACSS2-752ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACSS2
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Cat.#:ACSS2-9068HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ACSS2 293 Cell Lysate
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Involved Pathway

ACSS2 involved in several pathways and played different roles in them. We selected most pathways ACSS2 participated on our site, such as Glycolysis / Gluconeogenesis, Pyruvate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
pykF; PFKM; ACSS2L; ALDH2.2; PGM1; ENO1; LDHAL6B; ENO1B; LDHB; PGAM1A
Pyruvate metabolism
ackA; ALDH9A1B; MDH1AA; LDHB; ME3; DLDH; ALDH3A2A; LDHD; PDK3B; LDHA
Propanoate metabolism
ackA; LDHBA; ACADM; SUCLG1; HIBCH; ACSS2L; PCCA; LDHB; LDHBB; LDHC
Metabolic pathways
NDUFA2; BST1; G6PC; ALDH1A1; ALOX15; CYP2C39; AGPAT4; KLF15; MAN1A; POLE3
Carbon metabolism
IDH3A; MDH1AA; TPI1B; CAT; PSAT1; pykF; PGAM2; ACADS; PFKMB; PKMB

Protein Function

ACSS2 has several biochemical functions, for example, AMP binding, ATP binding, acetate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSS2 itself. We selected most functions ACSS2 had, and list some proteins which have the same functions with ACSS2. You can find most of the proteins on our site.
Function
Related Protein
Function AMP binding
Related Protein APRT; ACSS1; PRPS1; PRKAG1; PYGM; PRPS2; ACSS2; PYGL; CYB5R3; PRKAG2
Function ATP binding
Related Protein UBE2D2; PANK1B; HSPA4B; NLRP12; SIK2; ATP1A4; CDKL4; EHD1; SKIV2L; EIF4A3
Function acetate-CoA ligase activity
Related Protein ACSS3; ACSS1; ACSS2

Interacting Protein

ACSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSS2.
q2i360_hbv; purT; UPF1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; Smchd1; CTR9