adamts13
Share
  • Official Full Name
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13
  • Background
  • This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • Synonyms
  • ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13; A disintegrin and metalloproteinase with thrombospondin motifs 13; vWF-cleaving protease; von Willebrand factor-cleaving protease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13;
Cat.#:ADAMTS13-2684MTag:His|Myc
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse ADAMTS13 Protein (904-1137 aa), His-Myc-tagged
+Inquiry
Cat.#:ADAMTS13-136HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ADAMTS13 protein, His-tagged
+Inquiry
Cat.#:ADAMTS13-137HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAMTS13, MYC/DDK-tagged
+Inquiry
Cat.#:ADAMTS13-299HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAMTS13 Protein, GST-tagged
+Inquiry
Cat.#:ADAMTS13-5660HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS13 protein, His & T7-tagged
+Inquiry
Cat.#:ADAMTS13-5661HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS13 protein, His & GST-tagged
+Inquiry
Cat.#:ADAMTS13-820HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ADAMTS13 protein, His-tagged
+Inquiry
Cat.#:ADAMTS13-1310MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADAMTS13 Protein
+Inquiry

Involved Pathway

ADAMTS13 involved in several pathways and played different roles in them. We selected most pathways ADAMTS13 participated on our site, such as Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism of proteins
NEU3; IGFBP6; MLEC; GCNT3; SPCS3; TIMM17B; ARSK; GZMH; FKBP9; ZNF408
O-glycosylation of TSR domain-containing proteins
ADAMTS5; SPON2; C8orf84; THSD1; SPON1; ADAMTSL1; ADAMTS4; ADAMTSL4; ADAMTSL3; SPON1B
O-linked glycosylation
SSPO; C8orf84; MUC12; ADAMTS13; A4GNT; B3GNT2A; GALNT6; B3GNT8; KCNA6; SPON1A
Post-translational protein modification
SPON1; PPP6C; A4GNT; GALNT6; CTAGE5; PHC2; ADAMTS5; TRAPPC10; ALG2; B3GNT8

Protein Function

ADAMTS13 has several biochemical functions, for example, calcium ion binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS13 itself. We selected most functions ADAMTS13 had, and list some proteins which have the same functions with ADAMTS13. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PLA2G2A; VWCE; THBS1; S100A12; PCDHB14; PCDH2G12; CABP7; EGFL7; DGKG; HSPA5
Function integrin binding
Related Protein ACTN4; COL5A1; SYK; ITGB1BP1; S1PR2; WISP3; SFRP2; CYR61L1; EMP2; ICAM4
Function metalloendopeptidase activity
Related Protein ADAM5; ADAMTS4; ADAM10B; ADAM21; MMP26; ADAM20; THOP1; SPG7; Adamts19; YME1L1
Function metallopeptidase activity
Related Protein MMP14A; ADAM20; XPNPEP3; DPP3; MMP2; MYSM1; NAALAD2; DNPEP; MMP1A; ADAM18
Function protein binding
Related Protein C1QTNF2; TSPAN2; C12orf43; HMG20A; NUMBL; SENP5; SLA; POLR1D; ALDH18A1; ITGA2
Function zinc ion binding
Related Protein NAPEPLD; USP13; NR1H5; TRIM35-34; MORC3A; RNF43; RNF6; ANPEP; RXRGB; DPF2

Interacting Protein

ADAMTS13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS13 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS13.
VWF

ADAMTS13 Related Articles

Rossio, R; Lotta, LA; et al. A novel CD46 mutation in a patient with microangiopathy clinically resembling thrombotic thrombocytopenic purpura and normal ADAMTS13 activity. HAEMATOLOGICA 100:E87-E89(2015).
Becerra, E; Scully, MA; et al. Effect of rituximab on B cell phenotype and serum B cell-activating factor levels in patients with thrombotic thrombocytopenic purpura. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 179:414-425(2015).