AK1 Protein, adenylate kinase 1

AK1

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AK1

Official Full Name adenylate kinase 1
Background Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.
Synonyms AK1; adenylate kinase 1; adenylate kinase isoenzyme 1; AK 1; myokinase; ATP-AMP transphosphorylase 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rat
    • Zebrafish
    • Source :
    • Chicken Muscle
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AK1-1344H Recombinant Human AK1, His tagged E.coli His
    Human AK1-18H Recombinant Human AK1 protein E.coli N/A
    Human AK1-2864H Recombinant Human Adenylate Kinase 1, His-tagged E.coli His
    Human AK1-483H Recombinant Human AK1 Protein, GST-tagged Wheat Germ GST
    Human AK1-8948HCL Recombinant Human AK1 293 Cell Lysate HEK293 N/A
    Human AK1-9511H Recombinant Human AK1, GST-tagged E.coli GST
    Mouse AK1-1462M Recombinant Mouse AK1 Protein Mammalian Cell His
    Rat AK1-1123R Recombinant Rat AK1 Protein, His-tagged E.coli His
    Rat Ak1-3186R Recombinant Rat Ak1, His-tagged E.Coli or Yeast His
    Rat AK1-582R Recombinant Rat AK1 Protein Mammalian Cell His
    Chicken AK1-6666C Recombinant Chicken AK1 Mammalian Cell His
    Chicken AK1-6667C Native Chicken AK1 Chicken Muscle N/A
    Zebrafish AK1-1192Z Recombinant Zebrafish AK1 Mammalian Cell His
    Pig LOC100521423-3185P Recombinant Pig LOC100521423, His-tagged E.Coli or Yeast His

    AK1 involved in several pathways and played different roles in them. We selected most pathways AK1 participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism PDE6D; ADAL; POLR3F; NTPCR; NPR1; NT5C3B; POLR2H; NT5C1AA; NT5C1BA; TWISTNB
    Metabolic pathways HK1; GBA3; ACSS1; CMPK1; GAL3ST1A; MECR; PPAP2CB; PLCH1; MOGS; UGT1AB

    AK1 has several biochemical functions, for example, ATP binding, adenylate kinase activity, nucleoside diphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK1 itself. We selected most functions AK1 had, and list some proteins which have the same functions with AK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding STK25; LMTK2; UBE2A; DNAHC8; TTBK1; MVK; OASL; ATP1A3; HSPA12B; DNAH5
    adenylate kinase activity AK7; AK5; AK8; AK4; AK2; AK1
    nucleoside diphosphate kinase activity TXNDC3; NME2A; AK4; CMPK; NME3; NME2; NME2B.1; NME4; NME8; AK5

    AK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK1.

    KMT2C; TERF1; fldB; TINF2; TERF2IP; NBAS; MRE11A; TIA1; OGT; PCF11; CD2BP2; SLC12A2; DECR1; COBLL1; B3GALTL; RAB11FIP2; KDM3B; GEMIN5; CIRH1A

    Xu, ZS; Du, WD; et al. Development of a Protein Biochip to Identify 6 Monoclonal Antibodies Against Subtypes of Recombinant Human Interferons. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES 8:212-218(2010).
    Ravera, S; Musante, L; et al. Expression of adenylate kinase 1 in bovine retinal cytosol. CURRENT EYE RESEARCH 32:249-257(2007).

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